BACKGROUND: Pulmonary complications secondary to dysphagia may be encountered in patients with nasopharyngeal carcinoma (NPC) after definitive intensity-modulated radiotherapy. The purpose of this study was to identify patients with NPC at risk of developing swallowing-related chest infections (SRCIs). METHODS: Retrospective chart review was performed on 217 patients with stage I to IVB NPC treated definitively with radiotherapy or chemoradiotherapy. RESULTS: Twenty-six patients (12.0%) developed SRCIs; 4 of these patients (15.3%) required intensive care unit (ICU) admission and 9 (34.6%) died of the complication. The median time interval between completions of radiotherapy to the development of SRCIs was 24.5 months. Advanced age, recurrent disease, and concurrent chemoradiotherapy were significantly associated with the development of SRCIs in the multivariable analysis. CONCLUSION: SRCI is a common and potentially fatal complication for postirradiated patients with NPC. Advanced age, concurrent chemoradiotherapy, and recurrent cancer were strong risk factors for postirradiated patients with NPC to develop SRCIs.
BACKGROUND: Pulmonary complications secondary to dysphagia may be encountered in patients with nasopharyngeal carcinoma (NPC) after definitive intensity-modulated radiotherapy. The purpose of this study was to identify patients with NPC at risk of developing swallowing-related chest infections (SRCIs). METHODS: Retrospective chart review was performed on 217 patients with stage I to IVB NPC treated definitively with radiotherapy or chemoradiotherapy. RESULTS: Twenty-six patients (12.0%) developed SRCIs; 4 of these patients (15.3%) required intensive care unit (ICU) admission and 9 (34.6%) died of the complication. The median time interval between completions of radiotherapy to the development of SRCIs was 24.5 months. Advanced age, recurrent disease, and concurrent chemoradiotherapy were significantly associated with the development of SRCIs in the multivariable analysis. CONCLUSION: SRCI is a common and potentially fatal complication for postirradiated patients with NPC. Advanced age, concurrent chemoradiotherapy, and recurrent cancer were strong risk factors for postirradiated patients with NPC to develop SRCIs.
Authors: Peter K M Ku; Ki Wang; Alexander C Vlantis; Evelyn W K Tang; Thomas S C Hui; Ronald Lai; Zenon W C Yeung; Ryan H W Cho; Thomas Law; Simon Y P Chan; Becky Y T Chan; Jeffrey K T Wong; Andrew van Hasselt; Michael C F Tong Journal: Laryngoscope Investig Otolaryngol Date: 2021-11-27
Authors: Peter K M Ku; Alexander C Vlantis; Thomas S C Hui; David C M Yeung; Alex K F Lee; Thomas Law; Simon Y P Chan; Esther S M Poon; Sophie Y Y Lee; Becky Y T Chan; Twinky Y L Cheung; Laurie Y W Lok; Dennis T H Cheng; Jade W S Li; Ken C W Yam; Christina S M Ho; Kristy P T Fung; Coco S Y Chan; William H S Wang; Jeffrey K T Wong; Victor Abdullah; Andrew van Hasselt; Michael C F Tong Journal: Head Neck Date: 2021-09-15 Impact factor: 3.821
Authors: Sofiana Mootassim-Billah; Gwen Van Nuffelen; Jean Schoentgen; Marc De Bodt; Tatiana Dragan; Antoine Digonnet; Nicolas Roper; Dirk Van Gestel Journal: Cancer Rep (Hoboken) Date: 2021-05-01