Literature DB >> 26891038

Differences in expression of gut-homing receptors on CD4+ T cells in black and white HIV-negative men who have sex with men.

Colleen F Kelley1, Lilin Lai, Chris Ibegbu, Eli S Rosenberg, Surinder Kaur, Kalpana Patel, Mark J Mulligan, Vincent C Marconi, Patrick S Sullivan, Rama R Amara.   

Abstract

HIV incidence rates are higher among black men who have sex with men (BMSM) as compared with MSM of other race/ethnicities in the USA. We found that blood memory CD4 cells from BMSM express higher levels of α4β7, the gut-homing integrin, compared with white MSM. Higher expression of α4β7 on blood CD4 cells correlated with higher percentage of proliferating CD4α4β7 cells in rectal tissue suggesting increased trafficking of potential HIV target cells to rectal mucosa could increase HIV susceptibility among BMSM.

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Year:  2016        PMID： 26891038      PMCID： PMC4851564          DOI： 10.1097/QAD.0000000000001062

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  18 in total

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Authors:  U H von Andrian; C R Mackay
Journal:  N Engl J Med       Date:  2000-10-05       Impact factor: 91.245

2.  Estimating the proportion of HIV transmissions from main sex partners among men who have sex with men in five US cities.

Authors:  Patrick S Sullivan; Laura Salazar; Susan Buchbinder; Travis H Sanchez
Journal:  AIDS       Date:  2009-06-01       Impact factor: 4.177

3.  The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.

Authors:  Claudia Cicala; Elena Martinelli; Jonathan P McNally; Diana J Goode; Ravindra Gopaul; Joseph Hiatt; Katija Jelicic; Shyamasundaran Kottilil; Katilyn Macleod; Angeline O'Shea; Nikita Patel; Donald Van Ryk; Danlan Wei; Massimiliano Pascuccio; Ling Yi; Lyle McKinnon; Preson Izulla; Joshua Kimani; Rupert Kaul; Anthony S Fauci; James Arthos
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-20       Impact factor: 11.205

4.  Preferential and persistent depletion of CCR5+ T-helper lymphocytes with nonlymphoid homing potential despite early treatment of primary HIV infection.

Authors:  R Krzysiek; A Rudent; L Bouchet-Delbos; A Foussat; C Boutillon; A Portier; D Ingrand; D Sereni; P Galanaud; L Grangeot-Keros; D Emilie
Journal:  Blood       Date:  2001-11-15       Impact factor: 22.113

5.  Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals.

Authors:  S M Schnittman; H C Lane; J Greenhouse; J S Justement; M Baseler; A S Fauci
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

6.  Altered expression of alpha 4 beta 7, a gut homing integrin, by circulating and mucosal T cells in colonic mucosal inflammation.

Authors:  J Meenan; J Spaans; T A Grool; S T Pals; G N Tytgat; S J van Deventer
Journal:  Gut       Date:  1997-02       Impact factor: 23.059

7.  Monitoring alpha4beta7 integrin expression on circulating CD4+ T cells as a surrogate marker for tracking intestinal CD4+ T-cell loss in SIV infection.

Authors:  X Wang; H Xu; A F Gill; B Pahar; D Kempf; T Rasmussen; A A Lackner; R S Veazey
Journal:  Mucosal Immunol       Date:  2009-08-26       Impact factor: 7.313

8.  Alpha4(+)beta7(hi)CD4(+) memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection.

Authors:  M Kader; X Wang; M Piatak; J Lifson; M Roederer; R Veazey; J J Mattapallil
Journal:  Mucosal Immunol       Date:  2009-07-01       Impact factor: 7.313

Review 9.  Role of beta7 integrins in intestinal lymphocyte homing and retention.

Authors:  G Gorfu; J Rivera-Nieves; K Ley
Journal:  Curr Mol Med       Date:  2009-09       Impact factor: 2.222

10.  HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.

Authors:  James Arthos; Claudia Cicala; Elena Martinelli; Katilyn Macleod; Donald Van Ryk; Danlan Wei; Zhen Xiao; Timothy D Veenstra; Thomas P Conrad; Richard A Lempicki; Sherry McLaughlin; Massimiliano Pascuccio; Ravindra Gopaul; Jonathan McNally; Catherine C Cruz; Nina Censoplano; Eva Chung; Kristin N Reitano; Shyam Kottilil; Diana J Goode; Anthony S Fauci
Journal:  Nat Immunol       Date:  2008-02-10       Impact factor: 25.606
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  6 in total

1.  The V2 loop of HIV gp120 delivers costimulatory signals to CD4+ T cells through Integrin α4β7 and promotes cellular activation and infection.

Authors:  Livia R Goes; Alia Sajani; Aida Sivro; Ronke Olowojesiku; Jocelyn C Ray; Ian Perrone; Jason Yolitz; Alexandre Girard; Louise Leyre; Constantinos Kurt Wibmer; Lynn Morris; Giacomo Gorini; Genoveffa Franchini; Rosemarie D Mason; Mario Roederer; Saurabh Mehandru; Marcelo A Soares; Claudia Cicala; Anthony S Fauci; James Arthos
Journal:  Proc Natl Acad Sci U S A       Date:  2020-12-07       Impact factor: 11.205

2.  Gut-homing α4β7 CD4+ T cells: potential key players in both acute HIV infection and HIV-associated cancers.

Authors:  Yang Wang; Xiaofan Lu; Hao Wu; Wei Li
Journal:  Cell Mol Immunol       Date:  2017-10-30       Impact factor: 11.530

3.  αEβ7, α4β7 and α4β1 integrin contributions to T cell distribution in blood, cervix and rectal tissues: Potential implications for HIV transmission.

Authors:  Catia T Perciani; Walter Jaoko; Bashir Farah; Mario A Ostrowski; Omu Anzala; Kelly S MacDonald
Journal:  PLoS One       Date:  2018-02-08       Impact factor: 3.240

4.  Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs.

Authors:  Alyssa R Martin; Aida Sivro; Zoe R Packman; Eshan U Patel; Livia R Goes; Lyle R McKinnon; Jacquie Astemborski; Gregory D Kirk; Shruti H Mehta; Claudia Cicala; James Arthos; Andrew D Redd; Thomas C Quinn
Journal:  PLoS One       Date:  2020-08-25       Impact factor: 3.752

5.  MAdCAM costimulation through Integrin-α4β7 promotes HIV replication.

Authors:  Fatima Nawaz; Livia R Goes; Jocelyn C Ray; Ronke Olowojesiku; Alia Sajani; Aftab A Ansari; Ian Perrone; Joseph Hiatt; Donald Van Ryk; Danlan Wei; Mia Waliszewski; Marcelo A Soares; Katija Jelicic; Mark Connors; Stephen A Migueles; Elena Martinelli; Francois Villinger; Claudia Cicala; Anthony S Fauci; James Arthos
Journal:  Mucosal Immunol       Date:  2018-06-06       Impact factor: 7.313

Review 6.  The Role of Integrin α4β7 in HIV Pathogenesis and Treatment.

Authors:  James Arthos; Claudia Cicala; Fatima Nawaz; Siddappa N Byrareddy; Francois Villinger; Philip J Santangelo; Aftab A Ansari; Anthony S Fauci
Journal:  Curr HIV/AIDS Rep       Date:  2018-04       Impact factor: 5.071
  6 in total

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