A A Allshouse1, R H Jessel2, K D Heyborne2,3. 1. University of Colorado School of Public Health, Aurora, CO, USA. 2. Department of Obstetrics and Gynecology, University of Colorado Denver, Aurora, CO, USA. 3. Department of Obstetrics and Gynecology, Denver Health and Hospital Authority, Denver, CO, USA.
Abstract
OBJECTIVE: The objective of this study is to determine whether low-dose aspirin (LDA) reduced the rate of preterm birth (PTB) in a cohort of women at high risk for preeclampsia. STUDY DESIGN: Secondary analysis of the Maternal-Fetal Medicine Units High-Risk Aspirin trial. Preterm births were categorized by phenotype: indicated, spontaneous or due to preterm premature rupture of membranes (PPROMs). RESULTS: Of 1789 randomized women, 30.5% delivered before 37 weeks (18.5% indicated, 5.8% spontaneous and 6.2% following preterm PPROMs). Among women randomized to LDA, we observed a trend favoring fewer PTBs due to spontaneous preterm labor and preterm PPROMs, odds ratio (OR: 0.826 (0.620, 1.099)); the incidence of indicated PTBs appeared unchanged, OR: 0.999 (0.787, 1.268). CONCLUSION: Although not reaching significance, we observed an effect size similar to other studies of both low- and high-risk women. These results support findings from other studies assessing LDA as a PTB prevention strategy.
RCT Entities:
OBJECTIVE: The objective of this study is to determine whether low-dose aspirin (LDA) reduced the rate of preterm birth (PTB) in a cohort of women at high risk for preeclampsia. STUDY DESIGN: Secondary analysis of the Maternal-Fetal Medicine Units High-Risk Aspirin trial. Preterm births were categorized by phenotype: indicated, spontaneous or due to preterm premature rupture of membranes (PPROMs). RESULTS: Of 1789 randomized women, 30.5% delivered before 37 weeks (18.5% indicated, 5.8% spontaneous and 6.2% following preterm PPROMs). Among women randomized to LDA, we observed a trend favoring fewer PTBs due to spontaneous preterm labor and preterm PPROMs, odds ratio (OR: 0.826 (0.620, 1.099)); the incidence of indicated PTBs appeared unchanged, OR: 0.999 (0.787, 1.268). CONCLUSION: Although not reaching significance, we observed an effect size similar to other studies of both low- and high-risk women. These results support findings from other studies assessing LDA as a PTB prevention strategy.
Authors: Jillian T Henderson; Evelyn P Whitlock; Elizabeth O'Connor; Caitlyn A Senger; Jamie H Thompson; Maya G Rowland Journal: Ann Intern Med Date: 2014-05-20 Impact factor: 25.391
Authors: Anadeijda J E M C Landman; Marjon A de Boer; Laura Visser; Tobias A J Nijman; Marieke A C Hemels; Christiana N Naaktgeboren; Marijke C van der Weide; Ben W Mol; Judith O E H van Laar; Dimitri N M Papatsonis; Mireille N Bekker; Joris van Drongelen; Mariëlle G van Pampus; Marieke Sueters; David P van der Ham; J Marko Sikkema; Joost J Zwart; Anjoke J M Huisjes; Marloes E van Huizen; Gunilla Kleiverda; Janine Boon; Maureen T M Franssen; Wietske Hermes; Harry Visser; Christianne J M de Groot; Martijn A Oudijk Journal: PLoS Med Date: 2022-02-01 Impact factor: 11.069