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Literature DB >> 26890076

Glycation Reactivity of a Quorum-Sensing Signaling Molecule.

Kyoji Tsuchikama¹, Major Gooyit¹, Tyler L Harris¹, Jie Zhu¹, Daniel Globisch¹, Gunnar F Kaufmann¹, Kim D Janda^2,3.

Abstract

Reported herein is that (4S)-4,5-dihydroxy-2,3-pentanedione (DPD) can undergo a previously undocumented non-enzymatic glycation reaction. Incubation of DPD with viral DNA or the antibiotic gramicidin S resulted in significant biochemical alterations. A protein-labeling method was consequently developed that facilitated the identification of unrecognized glycation targets of DPD in a prokaryotic system. These results open new avenues toward tracking and understanding the fate and function of the elusive quorum-sensing signaling molecule.

Entities: CellLine Chemical Disease Species

Keywords: fluorescent probes; glycation; protein modifications; proteomics; quorum sensing

Mesh：

Substances：

Year: 2016 PMID： 26890076 PMCID： PMC4965832 DOI： 10.1002/anie.201511911

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

36 in total

1. Synthetic analogs tailor native AI-2 signaling across bacterial species.

Authors: Varnika Roy; Jacqueline A I Smith; Jingxin Wang; Jessica E Stewart; William E Bentley; Herman O Sintim
Journal: J Am Chem Soc Date: 2010-08-18 Impact factor: 15.419

Review 2. Making 'sense' of metabolism: autoinducer-2, LuxS and pathogenic bacteria.

Authors: Agnès Vendeville; Klaus Winzer; Karin Heurlier; Christoph M Tang; Kim R Hardie
Journal: Nat Rev Microbiol Date: 2005-05 Impact factor: 60.633

3. Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.

Authors: Christian A Luber; Jürgen Cox; Henning Lauterbach; Ben Fancke; Matthias Selbach; Jurg Tschopp; Shizuo Akira; Marian Wiegand; Hubertus Hochrein; Meredith O'Keeffe; Matthias Mann
Journal: Immunity Date: 2010-02-18 Impact factor: 31.745

4. Detection of alpha-dicarbonyl compounds in Maillard reaction systems and in vivo.

Authors: M A Glomb; R Tschirnich
Journal: J Agric Food Chem Date: 2001-11 Impact factor: 5.279

5. Characteristics and mechanisms of high-glucose-induced overexpression of basement membrane components in cultured human endothelial cells.

Authors: E Cagliero; T Roth; S Roy; M Lorenzi
Journal: Diabetes Date: 1991-01 Impact factor: 9.461

10. Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.

Authors: T W Lo; M E Westwood; A C McLellan; T Selwood; P J Thornalley
Journal: J Biol Chem Date: 1994-12-23 Impact factor: 5.157

1 in total

1. Near-Infrared Light-Enhanced Protease-Conjugated Gold Nanorods As A Photothermal Antimicrobial Agent For Elimination Of Exotoxin And Biofilms.

Authors: Wei Li; Xu Geng; Dongni Liu; Zhengqiang Li
Journal: Int J Nanomedicine Date: 2019-10-04

1 in total

Glycation Reactivity of a Quorum-Sensing Signaling Molecule.

1. Synthetic analogs tailor native AI-2 signaling across bacterial species.

Review 2. Making 'sense' of metabolism: autoinducer-2, LuxS and pathogenic bacteria.

3. Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.

4. Detection of alpha-dicarbonyl compounds in Maillard reaction systems and in vivo.

5. Characteristics and mechanisms of high-glucose-induced overexpression of basement membrane components in cultured human endothelial cells.

6. Large shifts in pKa values of lysine residues buried inside a protein.

7. Glycation isotopic labeling with 13C-reducing sugars for quantitative analysis of glycated proteins in human plasma.

8. Gramicidin S: a peptide model for protein glycation and reversal of glycation using nucleophilic amines.

9. Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: effects on small RNA and biofilm architecture.

10. Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.

1. Near-Infrared Light-Enhanced Protease-Conjugated Gold Nanorods As A Photothermal Antimicrobial Agent For Elimination Of Exotoxin And Biofilms.