Literature DB >> 26889022

Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels.

W Widagdo1, V Stalin Raj1, Debby Schipper1, Kimberley Kolijn2, Geert J L H van Leenders2, Berend J Bosch3, Albert Bensaid4, Joaquim Segalés5,6, Wolfgang Baumgärtner7, Albert D M E Osterhaus1,8,9, Marion P Koopmans1, Judith M A van den Brand1, Bart L Haagmans10.   

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor--dipeptidyl peptidase 4 (DPP4)--is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 26889022      PMCID： PMC4836314          DOI： 10.1128/JVI.02994-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

1.  Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques.

Authors:  Li Liu; Qiang Wei; Xavier Alvarez; Haibo Wang; Yanhua Du; Hua Zhu; Hong Jiang; Jingying Zhou; Pokman Lam; Linqi Zhang; Andrew Lackner; Chuan Qin; Zhiwei Chen
Journal:  J Virol       Date:  2011-02-02       Impact factor: 5.103

Review 2.  The multifunctional or moonlighting protein CD26/DPPIV.

Authors:  Emil Boonacker; Cornelis J F Van Noorden
Journal:  Eur J Cell Biol       Date:  2003-02       Impact factor: 4.492

3.  Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012.

Authors:  A Bermingham; M A Chand; C S Brown; E Aarons; C Tong; C Langrish; K Hoschler; K Brown; M Galiano; R Myers; R G Pebody; H K Green; N L Boddington; R Gopal; N Price; W Newsholme; C Drosten; R A Fouchier; M Zambon
Journal:  Euro Surveill       Date:  2012-10-04

4.  Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan, June to September 2013.

Authors:  C B Reusken; M Ababneh; V S Raj; B Meyer; A Eljarah; S Abutarbush; G J Godeke; T M Bestebroer; I Zutt; M A Muller; B J Bosch; P J Rottier; A D Osterhaus; C Drosten; B L Haagmans; M P Koopmans
Journal:  Euro Surveill       Date:  2013-12-12

5.  Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels.

Authors:  Danielle R Adney; Neeltje van Doremalen; Vienna R Brown; Trenton Bushmaker; Dana Scott; Emmie de Wit; Richard A Bowen; Vincent J Munster
Journal:  Emerg Infect Dis       Date:  2014-12       Impact factor: 6.883

Review 6.  Human coronaviruses: insights into environmental resistance and its influence on the development of new antiseptic strategies.

Authors:  Chloé Geller; Mihayl Varbanov; Raphaël E Duval
Journal:  Viruses       Date:  2012-11-12       Impact factor: 5.048

7.  State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans.

Authors: 
Journal:  PLoS Curr       Date:  2013-11-12

8.  MERS coronavirus in dromedary camel herd, Saudi Arabia.

Authors:  Maged G Hemida; Daniel K W Chu; Leo L M Poon; Ranawaka A P M Perera; Mohammad A Alhammadi; Hoi-Yee Ng; Lewis Y Siu; Yi Guan; Abdelmohsen Alnaeem; Malik Peiris
Journal:  Emerg Infect Dis       Date:  2014-07       Impact factor: 6.883

9.  MERS coronavirus neutralizing antibodies in camels, Eastern Africa, 1983-1997.

Authors:  Marcel A Müller; Victor Max Corman; Joerg Jores; Benjamin Meyer; Mario Younan; Anne Liljander; Berend-Jan Bosch; Erik Lattwein; Mosaad Hilali; Bakri E Musa; Set Bornstein; Christian Drosten
Journal:  Emerg Infect Dis       Date:  2014-12       Impact factor: 6.883

10.  Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study.

Authors:  Z A Memish; J A Al-Tawfiq; H Q Makhdoom; A A Al-Rabeeah; A Assiri; R F Alhakeem; F A AlRabiah; S Al Hajjar; A Albarrak; H Flemban; H Balkhy; M Barry; S Alhassan; S Alsubaie; A Zumla
Journal:  Clin Microbiol Infect       Date:  2014-02-17       Impact factor: 8.067
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  48 in total

1.  Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice.

Authors:  Kun Li; Christine L Wohlford-Lenane; Rudragouda Channappanavar; Jung-Eun Park; James T Earnest; Thomas B Bair; Amber M Bates; Kim A Brogden; Heather A Flaherty; Tom Gallagher; David K Meyerholz; Stanley Perlman; Paul B McCray
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-27       Impact factor: 11.205

2.  Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein.

Authors:  Wentao Li; Ruben J G Hulswit; Ivy Widjaja; V Stalin Raj; Ryan McBride; Wenjie Peng; W Widagdo; M Alejandra Tortorici; Brenda van Dieren; Yifei Lang; Jan W M van Lent; James C Paulson; Cornelis A M de Haan; Raoul J de Groot; Frank J M van Kuppeveld; Bart L Haagmans; Berend-Jan Bosch
Journal:  Proc Natl Acad Sci U S A       Date:  2017-09-18       Impact factor: 11.205

3.  Increased Pathogenicity and Virulence of Middle East Respiratory Syndrome Coronavirus Clade B In Vitro and In Vivo.

Authors:  Yanqun Wang; Jing Sun; Xiaobo Li; Airu Zhu; Wenda Guan; De-Qiang Sun; Jingxian Zhao; Jicheng Huang; Jincun Zhao; Mian Gan; Xuefeng Niu; Jun Dai; Lu Zhang; Zhaoyong Zhang; Yongxia Shi; Shuxiang Huang; Chris Ka Pun Mok; Zifeng Yang; Zhongfang Wang; Wenjie Tan; Yimin Li; Ling Chen; Rongchang Chen; Malik Peiris; Nanshan Zhong
Journal:  J Virol       Date:  2020-07-16       Impact factor: 5.103

Review 4.  Roles of Sialyl Glycans in HCoV-OC43, HCoV-HKU1, MERS-CoV and SARS-CoV-2 Infections.

Authors:  Nongluk Sriwilaijaroen; Yasuo Suzuki
Journal:  Methods Mol Biol       Date:  2022

5.  Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus.

Authors:  Mitra Gultom; Annika Kratzel; Jasmine Portmann; Hanspeter Stalder; Astrid Chanfon Bätzner; Hans Gantenbein; Corinne Gurtner; Nadine Ebert; Hans Henrik Gad; Rune Hartmann; Horst Posthaus; Patrik Zanolari; Stephanie Pfaender; Volker Thiel; Ronald Dijkman
Journal:  Sci Rep       Date:  2022-06-20       Impact factor: 4.996

Review 6.  Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus.

Authors:  Anthony R Fehr; Rudragouda Channappanavar; Stanley Perlman
Journal:  Annu Rev Med       Date:  2016-08-26       Impact factor: 13.739

7.  The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature.

Authors:  Marissa LoPresti; David B Beck; Priya Duggal; Derek A T Cummings; Benjamin D Solomon
Journal:  medRxiv       Date:  2020-06-03

Review 8.  Coronaviruses in humans and animals: the role of bats in viral evolution.

Authors:  Amr El-Sayed; Mohamed Kamel
Journal:  Environ Sci Pollut Res Int       Date:  2021-03-02       Impact factor: 5.190

9.  Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens.

Authors:  Vishwanatha R A P Reddy; Ivan Trus; Lowiese M B Desmarets; Yewei Li; Sebastiaan Theuns; Hans J Nauwynck
Journal:  Vet Res       Date:  2016-07-13       Impact factor: 3.683

Review 10.  An Opportunistic Pathogen Afforded Ample Opportunities: Middle East Respiratory Syndrome Coronavirus.

Authors:  Ian M Mackay; Katherine E Arden
Journal:  Viruses       Date:  2017-12-02       Impact factor: 5.048
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