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Literature DB >> 26888432

Novel targets for mitochondrial medicine.

Wang Wang¹, Georgios Karamanlidis², Rong Tian¹.

Abstract

Mitochondria-classically viewed as the powerhouses of the cell-have taken center stage in disease pathogenesis and resolution. Mitochondrial dysfunction, which originates from primary defects within the organelle or is induced by environmental stresses, plays a critical role in human disease. Despite their central role in human health and disease, there are no approved drugs that directly target mitochondria. We present possible new druggable targets in mitochondrial biology, including protein modification, calcium ion (Ca(2+)) transport, and dynamics, as we move into a new era of mitochondrial medicine.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2016 PMID： 26888432 PMCID： PMC4819426 DOI： 10.1126/scitranslmed.aac7410

Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956

88 in total

1. Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1.

Authors: Iain Scott; Bradley R Webster; Jian H Li; Michael N Sack
Journal: Biochem J Date: 2012-05-01 Impact factor: 3.857

2. Efficacy of idebenone on respiratory function in patients with Duchenne muscular dystrophy not using glucocorticoids (DELOS): a double-blind randomised placebo-controlled phase 3 trial.

Authors: Gunnar M Buyse; Thomas Voit; Ulrike Schara; Chiara S M Straathof; M Grazia D'Angelo; Günther Bernert; Jean-Marie Cuisset; Richard S Finkel; Nathalie Goemans; Craig M McDonald; Christian Rummey; Thomas Meier
Journal: Lancet Date: 2015-04-20 Impact factor: 79.321

3. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.

Authors: Xin Qi; Nir Qvit; Yu-Chin Su; Daria Mochly-Rosen
Journal: J Cell Sci Date: 2012-12-13 Impact factor: 5.285

4. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Authors: Jun Yoshino; Kathryn F Mills; Myeong Jin Yoon; Shin-ichiro Imai
Journal: Cell Metab Date: 2011-10-05 Impact factor: 27.287

5. Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury.

Authors: Derek J Hausenloy; Michael R Duchen; Derek M Yellon
Journal: Cardiovasc Res Date: 2003-12-01 Impact factor: 10.787

Review 6. Cancer therapy: Targeting mitochondria and other sub-cellular organelles.

Authors: Obinna C Ubah; Heather M Wallace
Journal: Curr Pharm Des Date: 2014 Impact factor: 3.116

7. Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results.

Authors: Dan Atar; Håkan Arheden; Alain Berdeaux; Jean-Louis Bonnet; Marcus Carlsson; Peter Clemmensen; Valérie Cuvier; Nicolas Danchin; Jean-Luc Dubois-Randé; Henrik Engblom; David Erlinge; Hüseyin Firat; Sigrun Halvorsen; Henrik Steen Hansen; Wilfried Hauke; Einar Heiberg; Sasha Koul; Alf-Inge Larsen; Philippe Le Corvoisier; Jan Erik Nordrehaug; Franck Paganelli; Rebecca M Pruss; Hélène Rousseau; Sophie Schaller; Giles Sonou; Vegard Tuseth; Julien Veys; Eric Vicaut; Svend Eggert Jensen
Journal: Eur Heart J Date: 2014-09-01 Impact factor: 29.983

8. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.

Authors: Gelin Wang; Ting Han; Deepak Nijhawan; Pano Theodoropoulos; Jacinth Naidoo; Sivaramakrishnan Yadavalli; Hamid Mirzaei; Andrew A Pieper; Joseph M Ready; Steven L McKnight
Journal: Cell Date: 2014-09-11 Impact factor: 41.582

Review 9. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury.

Authors: Elizabeth Murphy; Charles Steenbergen
Journal: Physiol Rev Date: 2008-04 Impact factor: 37.312

10. Towards germline gene therapy of inherited mitochondrial diseases.

Authors: Masahito Tachibana; Paula Amato; Michelle Sparman; Joy Woodward; Dario Melguizo Sanchis; Hong Ma; Nuria Marti Gutierrez; Rebecca Tippner-Hedges; Eunju Kang; Hyo-Sang Lee; Cathy Ramsey; Keith Masterson; David Battaglia; David Lee; Diana Wu; Jeffrey Jensen; Phillip Patton; Sumita Gokhale; Richard Stouffer; Shoukhrat Mitalipov
Journal: Nature Date: 2012-10-24 Impact factor: 49.962

54 in total

Review 1. Inter and Intracellular mitochondrial trafficking in health and disease.

Authors: Santhanam Shanmughapriya; Dianne Langford; Kalimuthusamy Natarajaseenivasan
Journal: Ageing Res Rev Date: 2020-07-23 Impact factor: 10.895

Review 2. Why don't mice lacking the mitochondrial Ca²⁺ uniporter experience an energy crisis?

Authors: Pei Wang; Celia Fernandez-Sanz; Wang Wang; Shey-Shing Sheu
Journal: J Physiol Date: 2018-10-11 Impact factor: 5.182

3. Failed Power Plant Turns Into Mass Murder: New Insight on Mitochondrial Cardiomyopathy.

Authors: Chi Fung Lee; Yang Cao; Rong Tian
Journal: Circ Res Date: 2018-01-05 Impact factor: 17.367

Review 4. Regulation of mitochondrial bioenergetics by the non-canonical roles of mitochondrial dynamics proteins in the heart.

Authors: Wang Wang; Celia Fernandez-Sanz; Shey-Shing Sheu
Journal: Biochim Biophys Acta Mol Basis Dis Date: 2017-09-14 Impact factor: 5.187

5. Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network.

Authors: Valentina Parra; Francisco Altamirano; Carolina P Hernández-Fuentes; Dan Tong; Victoriia Kyrychenko; David Rotter; Zully Pedrozo; Joseph A Hill; Verónica Eisner; Sergio Lavandero; Jay W Schneider; Beverly A Rothermel
Journal: Circ Res Date: 2018-01-23 Impact factor: 17.367

Novel targets for mitochondrial medicine.

1. Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1.

2. Efficacy of idebenone on respiratory function in patients with Duchenne muscular dystrophy not using glucocorticoids (DELOS): a double-blind randomised placebo-controlled phase 3 trial.

3. A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.

4. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

5. Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury.

Review 6. Cancer therapy: Targeting mitochondria and other sub-cellular organelles.

7. Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results.

8. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.

Review 9. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury.

10. Towards germline gene therapy of inherited mitochondrial diseases.

Review 1. Inter and Intracellular mitochondrial trafficking in health and disease.

Review 2. Why don't mice lacking the mitochondrial Ca²⁺ uniporter experience an energy crisis?

3. Failed Power Plant Turns Into Mass Murder: New Insight on Mitochondrial Cardiomyopathy.

Review 4. Regulation of mitochondrial bioenergetics by the non-canonical roles of mitochondrial dynamics proteins in the heart.

5. Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network.

6. NAD(H) in mitochondrial energy transduction: implications for health and disease.

Review 7. Melatonin, mitochondria, and the cancer cell.

8. Raising NAD in Heart Failure: Time to Translate?

9. Crosstalk Between Mitochondrial Hyperacetylation and Oxidative Stress in Vascular Dysfunction and Hypertension.

Review 10. Mitochondrial regulation of diabetic vascular disease: an emerging opportunity.

Review 6. Cancer therapy: Targeting mitochondria and other sub-cellular organelles.

Review 9. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury.

Review 1. Inter and Intracellular mitochondrial trafficking in health and disease.

Review 2. Why don't mice lacking the mitochondrial Ca2+ uniporter experience an energy crisis?

Review 4. Regulation of mitochondrial bioenergetics by the non-canonical roles of mitochondrial dynamics proteins in the heart.

Review 7. Melatonin, mitochondria, and the cancer cell.

Review 10. Mitochondrial regulation of diabetic vascular disease: an emerging opportunity.

Review 2. Why don't mice lacking the mitochondrial Ca²⁺ uniporter experience an energy crisis?