| Literature DB >> 26888186 |
Wei Bu1, Gregory M Hayes2, Hui Liu2, Lorraine Gemmell2, David O Schmeling3, Pierce Radecki1, Fiona Aguilar1, Peter D Burbelo4, Jennifer Woo2, Henry H Balfour5, Jeffrey I Cohen6.
Abstract
Prospective studies of antibodies to multiple Epstein-Barr virus (EBV) proteins and EBV neutralizing antibodies in the same individuals before, during, and after primary EBV infection have not been reported. We studied antibody responses to EBV in college students who acquired primary EBV infection during prospective surveillance and correlated the kinetics of antibody response with the severity of disease. Neutralizing antibodies and enzyme-linked immunosorbent assay (ELISA) antibodies to gp350, the major target of neutralizing antibody, reached peak levels at medians of 179 and 333 days after the onset of symptoms of infectious mononucleosis, respectively. No clear correlation was found between the severity of the symptoms of infectious mononucleosis and the peak levels of antibody to individual viral proteins or to neutralizing antibody. In summary, we found that titers of neutralizing antibody and antibodies to multiple EBV proteins increase over many months after primary infection with EBV.Entities:
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Year: 2016 PMID： 26888186 PMCID： PMC4820504 DOI： 10.1128/CVI.00674-15
Source DB: PubMed Journal: Clin Vaccine Immunol ISSN： 1556-679X