Literature DB >> 26888066

Metformin: an Old Therapy that Deserves a New Indication for the Treatment of Obesity.

L I Igel1, A Sinha2, K H Saunders3, C M Apovian4, D Vojta5, L J Aronne3.   

Abstract

Metformin is not currently used for weight loss or diabetes prevention because it lacks an FDA indication for obesity and/or pre-diabetes treatment. Based on the evidence, metformin has been shown to decrease the incidence of type 2 diabetes, and compares favorably to other weight-loss medications in terms of efficacy as well as safety. Thus, metformin should be considered for a treatment indication in patients with these conditions.

Entities:  

Keywords:  Diabetes prevention; Metformin; Obesity; Pre-diabetes

Mesh：

Substances：

Year:  2016        PMID： 26888066     DOI： 10.1007/s11883-016-0568-3

Source DB:  PubMed          Journal:  Curr Atheroscler Rep        ISSN： 1523-3804            Impact factor:   5.113


  57 in total

Review 1.  Overweight in polycystic ovary syndrome. An update on evidence based advice on diet, exercise and metformin use for weight loss.

Authors:  P Ravn; A G Haugen; D Glintborg
Journal:  Minerva Endocrinol       Date:  2013-03       Impact factor: 2.184

2.  Metformin improves glucose effectiveness, not insulin sensitivity: predicting treatment response in women with polycystic ovary syndrome in an open-label, interventional study.

Authors:  Cindy T Pau; Candace Keefe; Jessica Duran; Corrine K Welt
Journal:  J Clin Endocrinol Metab       Date:  2014-02-25       Impact factor: 5.958

Review 3.  Body weight gain induced by antipsychotic drugs: mechanisms and management.

Authors:  T Baptista
Journal:  Acta Psychiatr Scand       Date:  1999-07       Impact factor: 6.392

Review 4.  Advantages of extended-release metformin in patients with type 2 diabetes mellitus.

Authors:  Serge Jabbour; Barry Ziring
Journal:  Postgrad Med       Date:  2011-01       Impact factor: 3.840

Review 5.  Clinical review: Drugs commonly associated with weight change: a systematic review and meta-analysis.

Authors:  Juan Pablo Domecq; Gabriela Prutsky; Aaron Leppin; M Bassam Sonbol; Osama Altayar; Chaitanya Undavalli; Zhen Wang; Tarig Elraiyah; Juan Pablo Brito; Karen F Mauck; Mohammed H Lababidi; Larry J Prokop; Noor Asi; Justin Wei; Salman Fidahussein; Victor M Montori; Mohammad Hassan Murad
Journal:  J Clin Endocrinol Metab       Date:  2015-01-15       Impact factor: 5.958

6.  Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial.

Authors:  Jolien de Jager; Adriaan Kooy; Philippe Lehert; Michiel G Wulffelé; Jan van der Kolk; Daniël Bets; Joop Verburg; Ab J M Donker; Coen D A Stehouwer
Journal:  BMJ       Date:  2010-05-20

Review 7.  Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.

Authors:  Shelley R Salpeter; Elizabeth Greyber; Gary A Pasternak; Edwin E Salpeter Posthumous
Journal:  Cochrane Database Syst Rev       Date:  2010-01-20

Review 8.  Effects of metformin on weight loss: potential mechanisms.

Authors:  Steven K Malin; Sangeeta R Kashyap
Journal:  Curr Opin Endocrinol Diabetes Obes       Date:  2014-10       Impact factor: 3.243

9.  Metformin addition attenuates olanzapine-induced weight gain in drug-naive first-episode schizophrenia patients: a double-blind, placebo-controlled study.

Authors:  Ren-Rong Wu; Jing-Ping Zhao; Xiao-Feng Guo; Yi-Qun He; Mao-Sheng Fang; Wen-Bin Guo; Jin-Dong Chen; Le-Hua Li
Journal:  Am J Psychiatry       Date:  2008-02-01       Impact factor: 18.112

10.  Determinants of weight gain in the action to control cardiovascular risk in diabetes trial.

Authors:  Vivian Fonseca; Roberta McDuffie; Jorge Calles; Robert M Cohen; Patricia Feeney; Mark Feinglos; Hertzel C Gerstein; Faramarz Ismail-Beigi; Timothy M Morgan; Rodica Pop-Busui; Matthew C Riddle
Journal:  Diabetes Care       Date:  2013-02-14       Impact factor: 19.112
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  13 in total

Review 1.  Obesity Treatment at HealthPartners: Adaptation of Clinical Guidelines into Systems for Practice Operations.

Authors:  Jennifer M Vesely; Nicolaas P Pronk; Thomas E Kottke; Peter S Marshall
Journal:  Curr Obes Rep       Date:  2016-09

Review 2.  Why Weight? An Analytic Review of Obesity Management, Diabetes Prevention, and Cardiovascular Risk Reduction.

Authors:  L I Igel; K H Saunders; J J Fins
Journal:  Curr Atheroscler Rep       Date:  2018-05-21       Impact factor: 5.113

3.  Determinants of weight change in patients on basal insulin treatment: an analysis of the DIVE registry.

Authors:  Peter Bramlage; Tobias Bluhmki; Holger Fleischmann; Matthias Kaltheuner; Jan Beyersmann; Reinhard W Holl; Thomas Danne
Journal:  BMJ Open Diabetes Res Care       Date:  2017-01-25

4.  Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin.

Authors:  Sara Kenawy; Rehab Hegazy; Azza Hassan; Siham El-Shenawy; Nawal Gomaa; Hala Zaki; Amina Attia
Journal:  PLoS One       Date:  2017-08-23       Impact factor: 3.240

Review 5.  Off-label drugs for weight management.

Authors:  Ed J Hendricks
Journal:  Diabetes Metab Syndr Obes       Date:  2017-06-10       Impact factor: 3.168

Review 6.  Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users.

Authors:  Fedra Luciano-Mateo; Anna Hernández-Aguilera; Noemi Cabre; Jordi Camps; Salvador Fernández-Arroyo; Jose Lopez-Miranda; Javier A Menendez; Jorge Joven
Journal:  Nutrients       Date:  2017-02-10       Impact factor: 5.717

7.  Metformin Alters Gut Microbiota of Healthy Mice: Implication for Its Potential Role in Gut Microbiota Homeostasis.

Authors:  Wei Ma; Ji Chen; Yuhong Meng; Jichun Yang; Qinghua Cui; Yuan Zhou
Journal:  Front Microbiol       Date:  2018-06-22       Impact factor: 5.640

8.  The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect.

Authors:  Kira Derkach; Irina Zakharova; Inna Zorina; Andrey Bakhtyukov; Irina Romanova; Liubov Bayunova; Alexander Shpakov
Journal:  PLoS One       Date:  2019-03-14       Impact factor: 3.240

9.  Utility of BMIQ, a novel web-based weight management programme, at an academic weight management centre.

Authors:  Sarah R Barenbaum; Sherin E Mathews; Katherine H Saunders; Guadalupe Minero; Elizabeth Mauer; Louis J Aronne; Alpana P Shukla
Journal:  Obes Sci Pract       Date:  2019-12-04

Review 10.  Metformin and Covid-19: Focused Review of Mechanisms and Current Literature Suggesting Benefit.

Authors:  Sherehan Ibrahim; Jamie R Lowe; Carolyn T Bramante; Surbhi Shah; Nichole R Klatt; Nancy Sherwood; Louis Aronne; Michael Puskarich; Leonardo Tamariz; Ana Palacio; Eric Bomberg; Michael Usher; Samantha King; Brad Benson; Deneen Vojta; Chris Tignanelli; Nicholas Ingraham
Journal:  Front Endocrinol (Lausanne)       Date:  2021-07-22       Impact factor: 5.555
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