Literature DB >> 26887498

DNA tags help the hunt for drugs.

Asher Mullard.   

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Year:  2016        PMID: 26887498     DOI: 10.1038/530367a

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


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  7 in total

1.  Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor.

Authors:  Zining Wu; Todd L Graybill; Xin Zeng; Michael Platchek; Jean Zhang; Vera Q Bodmer; David D Wisnoski; Jianghe Deng; Frank T Coppo; Gang Yao; Alex Tamburino; Genaro Scavello; G Joseph Franklin; Sibongile Mataruse; Katie L Bedard; Yun Ding; Jing Chai; Jennifer Summerfield; Paolo A Centrella; Jeffrey A Messer; Andrew J Pope; David I Israel
Journal:  ACS Comb Sci       Date:  2015-12-03       Impact factor: 3.784

2.  Encoded combinatorial chemistry.

Authors:  S Brenner; R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

3.  Design, synthesis and selection of DNA-encoded small-molecule libraries.

Authors:  Matthew A Clark; Raksha A Acharya; Christopher C Arico-Muendel; Svetlana L Belyanskaya; Dennis R Benjamin; Neil R Carlson; Paolo A Centrella; Cynthia H Chiu; Steffen P Creaser; John W Cuozzo; Christopher P Davie; Yun Ding; G Joseph Franklin; Kurt D Franzen; Malcolm L Gefter; Steven P Hale; Nils J V Hansen; David I Israel; Jinwei Jiang; Malcolm J Kavarana; Michael S Kelley; Christopher S Kollmann; Fan Li; Kenneth Lind; Sibongile Mataruse; Patricia F Medeiros; Jeffrey A Messer; Paul Myers; Heather O'Keefe; Matthew C Oliff; Cecil E Rise; Alexander L Satz; Steven R Skinner; Jennifer L Svendsen; Lujia Tang; Kurt van Vloten; Richard W Wagner; Gang Yao; Baoguang Zhao; Barry A Morgan
Journal:  Nat Chem Biol       Date:  2009-08-02       Impact factor: 15.040

Review 4.  Fidelity by design: Yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery.

Authors:  Peter Blakskjaer; Tara Heitner; Nils Jakob Vest Hansen
Journal:  Curr Opin Chem Biol       Date:  2015-02-28       Impact factor: 8.822

5.  Translation of DNA into a library of 13,000 synthetic small-molecule macrocycles suitable for in vitro selection.

Authors:  Brian N Tse; Thomas M Snyder; Yinghua Shen; David R Liu
Journal:  J Am Chem Soc       Date:  2008-10-29       Impact factor: 15.419

6.  Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.

Authors:  Juan Pablo Maianti; Amanda McFedries; Zachariah H Foda; Ralph E Kleiner; Xiu Quan Du; Malcolm A Leissring; Wei-Jen Tang; Maureen J Charron; Markus A Seeliger; Alan Saghatelian; David R Liu
Journal:  Nature       Date:  2014-05-21       Impact factor: 49.962

7.  Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.

Authors:  Aili L Lazaar; Lucy Yang; Rebecca L Boardley; Navin S Goyal; Jonathan Robertson; Sandra J Baldwin; David E Newby; Ian B Wilkinson; Ruth Tal-Singer; Ruth J Mayer; Joseph Cheriyan
Journal:  Br J Clin Pharmacol       Date:  2016-01-17       Impact factor: 4.335

  7 in total
  13 in total

1.  Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries.

Authors:  Kyle E Denton; Casey J Krusemark
Journal:  Medchemcomm       Date:  2016-08-02       Impact factor: 3.597

2.  Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis.

Authors:  James P Phelan; Simon B Lang; Jaehoon Sim; Simon Berritt; Andrew J Peat; Katelyn Billings; Lijun Fan; Gary A Molander
Journal:  J Am Chem Soc       Date:  2019-02-12       Impact factor: 15.419

3.  Metal-free deoxygenative coupling of alcohol-derived benzoates and pyridines for small molecules and DNA-encoded libraries synthesis.

Authors:  Sai Rohini Narayanan Kolusu; Manuel Nappi
Journal:  Chem Sci       Date:  2022-05-10       Impact factor: 9.969

Review 4.  Human Protein Tyrosine Phosphatase 1B (PTP1B): From Structure to Clinical Inhibitor Perspectives.

Authors:  Rongxing Liu; Cécile Mathieu; Jérémy Berthelet; Wenchao Zhang; Jean-Marie Dupret; Fernando Rodrigues Lima
Journal:  Int J Mol Sci       Date:  2022-06-24       Impact factor: 6.208

5.  Multifunctional Building Blocks Compatible with Photoredox-Mediated Alkylation for DNA-Encoded Library Synthesis.

Authors:  Shorouk O Badir; Jaehoon Sim; Katelyn Billings; Adam Csakai; Xuange Zhang; Weizhe Dong; Gary A Molander
Journal:  Org Lett       Date:  2020-01-15       Impact factor: 6.005

6.  Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening.

Authors:  Pedro P G Guimaraes; Rui Zhang; Roman Spektor; Mingchee Tan; Amanda Chung; Margaret M Billingsley; Rakan El-Mayta; Rachel S Riley; Lili Wang; James M Wilson; Michael J Mitchell
Journal:  J Control Release       Date:  2019-10-31       Impact factor: 9.776

7.  On-DNA Pd and Cu promoted C-N cross-coupling reactions.

Authors:  Xiaojie Lu; Sarah E Roberts; George J Franklin; Christopher P Davie
Journal:  Medchemcomm       Date:  2017-07-12       Impact factor: 3.597

8.  Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.

Authors:  Carl A Machutta; Christopher S Kollmann; Kenneth E Lind; Xiaopeng Bai; Pan F Chan; Jianzhong Huang; Lluis Ballell; Svetlana Belyanskaya; Gurdyal S Besra; David Barros-Aguirre; Robert H Bates; Paolo A Centrella; Sandy S Chang; Jing Chai; Anthony E Choudhry; Aaron Coffin; Christopher P Davie; Hongfeng Deng; Jianghe Deng; Yun Ding; Jason W Dodson; David T Fosbenner; Enoch N Gao; Taylor L Graham; Todd L Graybill; Karen Ingraham; Walter P Johnson; Bryan W King; Christopher R Kwiatkowski; Joël Lelièvre; Yue Li; Xiaorong Liu; Quinn Lu; Ruth Lehr; Alfonso Mendoza-Losana; John Martin; Lynn McCloskey; Patti McCormick; Heather P O'Keefe; Thomas O'Keeffe; Christina Pao; Christopher B Phelps; Hongwei Qi; Keith Rafferty; Genaro S Scavello; Matt S Steiginga; Flora S Sundersingh; Sharon M Sweitzer; Lawrence M Szewczuk; Amy Taylor; May Fern Toh; Juan Wang; Minghui Wang; Devan J Wilkins; Bing Xia; Gang Yao; Jean Zhang; Jingye Zhou; Christine P Donahue; Jeffrey A Messer; David Holmes; Christopher C Arico-Muendel; Andrew J Pope; Jeffrey W Gross; Ghotas Evindar
Journal:  Nat Commun       Date:  2017-07-17       Impact factor: 14.919

9.  Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules.

Authors:  Dmitry L Usanov; Alix I Chan; Juan Pablo Maianti; David R Liu
Journal:  Nat Chem       Date:  2018-04-02       Impact factor: 24.427

10.  Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation.

Authors:  Dafni C Delivoria; Sean Chia; Johnny Habchi; Michele Perni; Ilias Matis; Nikoletta Papaevgeniou; Martin Reczko; Niki Chondrogianni; Christopher M Dobson; Michele Vendruscolo; Georgios Skretas
Journal:  Sci Adv       Date:  2019-10-16       Impact factor: 14.136

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