| Literature DB >> 2688743 |
E J Blanchette Mackie1, N K Dwyer, M T Vanier, J Sokol, H F Merrick, M E Comly, C E Argoff, P G Pentchev.
Abstract
Biochemical and cytochemical studies have revealed that abnormal processing of low-density-lipoprotein (LDL) cholesterol can be reversed in mutant Niemann-Pick C (NP-C) fibroblasts when 2% dimethyl sulfoxide (DMSO) is added to the culture medium. Both the excessive lysosomal accumulation of LDL cholesterol and the delayed induction of cellular homeostatic responses associated with the uptake of LDL by the mutant cells were substantially reversed by DMSO. DMSO appears to accelerate the intracellular mobilization of LDL-derived cholesterol through effects that may reflect enhanced membrane permeability or cholesterol solubilization.Entities:
Mesh：
Substances：
Year: 1989 PMID： 2688743 DOI： 10.1016/0005-2760(89)90200-2
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002