| Literature DB >> 26886569 |
Aslam C Shaikh1,2, Dinesh R Shinde1,2, Nitin T Patil1,2.
Abstract
A site-selective C-4/C-8 alkynylation of isoquinolones catalyzed by gold and rhodium complexes is reported. A broad range of synthetically useful functional groups (-F, -Cl, -Br, -CF3, -OMe, alkyl, etc.) were tolerated, providing an efficient and robust protocol for the synthesis either C-4- or C-8-alkynylated isoquinolones.Entities:
Year: 2016 PMID： 26886569 DOI： 10.1021/acs.orglett.6b00175
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005