| Literature DB >> 26886414 |
Kazuya Sakai1, Takeshi Maeda1, Akira Kuriyama2, Noriaki Shimada3, Kenji Notohara4, Yasunori Ueda1.
Abstract
Thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome is considered as a unique clinicopathologic variant of multicentric Castleman's disease and is recently reported in Japan. This entity represents a severe inflammatory state leading to organ failures such as severe liver dysfunction seen in our case, and can be treated by immunosuppressive agents, steroids, and cyclosporine shown in several case reports. A systematic review and our case suggest the potential utility of tocilizumab as a treatment for TAFRO syndrome.Entities:
Keywords: Castleman’s disease; Liver injury; Systematic review; Thrombocytopenia; Tocilizumab; anasarca; and organomegaly syndrome; fever; reticulin fibrosis
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Year: 2016 PMID: 26886414 DOI: 10.3109/14397595.2015.1120389
Source DB: PubMed Journal: Mod Rheumatol ISSN: 1439-7595 Impact factor: 3.023