Hee Kyung Ahn1, In Cheol Hwang2, Ji Sung Lee3, Sun Jin Sym1, Eun Kyung Cho1, Dong Bok Shin1. 1. 1 Department of Internal Medicine, Gil Medical Center, Gachon University , Incheon, Republic of Korea. 2. 2 Department of Family Medicine, Gil Medical Center, Gachon University , Incheon, Republic of Korea. 3. 3 Department of Obstetrics and Gynecology, Gil Medical Center, Gachon University , Incheon, Republic of Korea.
Abstract
BACKGROUND: Neutrophil-lymphocyte count ratio (NLR) is a prognostic factor in cancer, although its prognostic significance in terminally ill cancer patients is not clear. OBJECTIVE: We investigated the association of NLR with survival in patients with terminal cancer. METHODS: We retrospectively investigated 205 consecutive patients with terminal cancer admitted to a palliative care unit during 2014. RESULTS: The median value of NLR was 9.7. In univariable analysis, NLR of 10 or more was significantly associated with shorter survival and NLR further discriminated survival of each palliative prognostic index (PPI) group. In multivariable analysis, increased NLR (≥10) was associated with shorter survival (hazards ratio [HR] 1.54, p<0.005), along with poor performance status (HR 1.55, p < 0.011), high PPI score (HR 1.59, p<0.003), and hyperbilirubinemia (HR 1.84, p < 0.001). CONCLUSION: Our results suggest that elevated NLR was an independent prognostic factor for poor survival in patients with terminal cancer.
BACKGROUND: Neutrophil-lymphocyte count ratio (NLR) is a prognostic factor in cancer, although its prognostic significance in terminally ill cancerpatients is not clear. OBJECTIVE: We investigated the association of NLR with survival in patients with terminal cancer. METHODS: We retrospectively investigated 205 consecutive patients with terminal cancer admitted to a palliative care unit during 2014. RESULTS: The median value of NLR was 9.7. In univariable analysis, NLR of 10 or more was significantly associated with shorter survival and NLR further discriminated survival of each palliative prognostic index (PPI) group. In multivariable analysis, increased NLR (≥10) was associated with shorter survival (hazards ratio [HR] 1.54, p<0.005), along with poor performance status (HR 1.55, p < 0.011), high PPI score (HR 1.59, p<0.003), and hyperbilirubinemia (HR 1.84, p < 0.001). CONCLUSION: Our results suggest that elevated NLR was an independent prognostic factor for poor survival in patients with terminal cancer.
Authors: Matteo Winker; Sandra Stössel; Philipp Zimmer; Jörg Faber; Marie Astrid Neu; Nadine Lehmann; Khalifa El Malki; Claudia Paret; Niklas Joisten; Wilhelm Bloch Journal: Support Care Cancer Date: 2021-12-03 Impact factor: 3.359
Authors: Justin M Lebenthal; Junting Zheng; Paul A Glare; Eileen M O'Reilly; Andrew C Yang; Andrew S Epstein Journal: Cancer Date: 2021-01-20 Impact factor: 6.860