Literature DB >> 26885254

Potential mechanisms underlying the Runx2 induced osteogenesis of bone marrow mesenchymal stem cells.

Jiahai Xu1, Zhanghua Li1, Yudong Hou1, Weijun Fang1.   

Abstract

Bone marrow derived mesenchymal stem cells (BM-MSCs) belong a type of pluripotent stem cells and can be induced to differentiate into osteoblasts (OB). Runt-related transcription factor 2 (Runx2) is an osteogenesis specific transcription factor and plays an important role in osteogenesis of BM-MSCs. It can promote the expression of osteogenesis related genes, regulate cell cycle progression, improve bone microenvironment and affect functions of chondrocytes and osteoclasts, which have involvement of a large amount of signal molecules including TGF-β, BMP, Notch, Wnt, Hedgehog, FGF and microRNA. In this paper, we summarize the mechanisms underlying the Runx2 induced osteogenesis of BM-MSCs.

Entities:  

Keywords:  Bone marrow derived mesenchymal stem cells; Runx2; osteogenic differentiation

Year:  2015        PMID： 26885254      PMCID： PMC4731654     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  43 in total

1.  A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program.

Authors:  Mohammad Q Hassan; Jonathan A R Gordon; Marcio M Beloti; Carlo M Croce; Andre J van Wijnen; Janet L Stein; Gary S Stein; Jane B Lian
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-27       Impact factor: 11.205

2.  Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.

Authors:  E Zelzer; D J Glotzer; C Hartmann; D Thomas; N Fukai; S Soker; B R Olsen
Journal:  Mech Dev       Date:  2001-08       Impact factor: 1.882

3.  Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein.

Authors:  Kyeong-Sook Lee; Seung-Hyun Hong; Suk-Chul Bae
Journal:  Oncogene       Date:  2002-10-17       Impact factor: 9.867

4.  Crucial roles of canonical Runx2-dependent pathway on Wnt1-induced osteoblastic differentiation of human periodontal ligament fibroblasts.

Authors:  Sung-Ho Kook; Jung Sun Heo; Jeong-Chae Lee
Journal:  Mol Cell Biochem       Date:  2015-01-25       Impact factor: 3.396

5.  Cbfa1/osf2 transduced bone marrow stromal cells facilitate bone formation in vitro and in vivo.

Authors:  H Zheng; Z Guo; Q Ma; H Jia; G Dang
Journal:  Calcif Tissue Int       Date:  2003-11-06       Impact factor: 4.333

6.  Jagged1 is essential for osteoblast development during maxillary ossification.

Authors:  Cynthia R Hill; Masato Yuasa; Jonathan Schoenecker; Steven L Goudy
Journal:  Bone       Date:  2014-02-01       Impact factor: 4.398

7.  MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation.

Authors:  Jian Huang; Lan Zhao; Lianping Xing; Di Chen
Journal:  Stem Cells       Date:  2010-02       Impact factor: 6.277

Review 8.  TGF-β and BMP signaling in osteoblast differentiation and bone formation.

Authors:  Guiqian Chen; Chuxia Deng; Yi-Ping Li
Journal:  Int J Biol Sci       Date:  2012-01-21       Impact factor: 6.580

9.  Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures.

Authors:  W Liu; S Toyosawa; T Furuichi; N Kanatani; C Yoshida; Y Liu; M Himeno; S Narai; A Yamaguchi; T Komori
Journal:  J Cell Biol       Date:  2001-10-01       Impact factor: 10.539

Review 10.  The role of microRNAs in cell fate determination of mesenchymal stem cells: balancing adipogenesis and osteogenesis.

Authors:  Hara Kang; Akiko Hata
Journal:  BMB Rep       Date:  2015-06       Impact factor: 4.778
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  61 in total

Review 1.  Biological functions of mesenchymal stem cells and clinical implications.

Authors:  Abderrahim Naji; Masamitsu Eitoku; Benoit Favier; Frédéric Deschaseaux; Nathalie Rouas-Freiss; Narufumi Suganuma
Journal:  Cell Mol Life Sci       Date:  2019-05-04       Impact factor: 9.261

2.  Tissue engineering using 3D printed nano-bioactive glass loaded with NELL1 gene for repairing alveolar bone defects.

Authors:  Jing Zhang; Yang Chen; Jing Xu; Jingjing Wang; Chengzhang Li; Liyan Wang
Journal:  Regen Biomater       Date:  2018-07-31

3.  Wnt5a mediated canonical Wnt signaling pathway activation in orthodontic tooth movement: possible role in the tension force-induced bone formation.

Authors:  Hai-Di Fu; Bei-Ke Wang; Zi-Qiu Wan; Heng Lin; Mao-Lin Chang; Guang-Li Han
Journal:  J Mol Histol       Date:  2016-07-25       Impact factor: 2.611

4.  Mesenchymal stem cells with osteogenic potential in human maxillary sinus membrane: an in vitro study.

Authors:  Antoine Berbéri; Fatima Al-Nemer; Eva Hamade; Ziad Noujeim; Bassam Badran; Kazem Zibara
Journal:  Clin Oral Investig       Date:  2016-09-01       Impact factor: 3.573

5.  Rutin promotes osteogenic differentiation of periodontal ligament stem cells through the GPR30-mediated PI3K/AKT/mTOR signaling pathway.

Authors:  Bin Zhao; Yixuan Xiong; Yunpeng Zhang; Linglu Jia; Wenjing Zhang; Xin Xu
Journal:  Exp Biol Med (Maywood)       Date:  2020-02-09

6.  Design and Fabrication of a Hierarchically Structured Scaffold for Tendon-to-Bone Repair.

Authors:  Chunlei Zhu; Suphannee Pongkitwitoon; Jichuan Qiu; Stavros Thomopoulos; Younan Xia
Journal:  Adv Mater       Date:  2018-03-13       Impact factor: 30.849

7.  [Role of growth arrest-specific protein 6 in migration and osteogenic differentiation of human periodontal ligament cells].

Authors:  S N Zhang; N An; X Y Ouyang; Y J Liu; X K Wang
Journal:  Beijing Da Xue Xue Bao Yi Xue Ban       Date:  2020-12-28

8.  Multifunctional nanoparticles for intracellular drug delivery and photoacoustic imaging of mesenchymal stem cells.

Authors:  Isaac M Adjei; Hao Yang; Glendon Plumton; Lorena Maldonado-Camargo; Jon Dobson; Carlos Rinaldi; Huabei Jiang; Blanka Sharma
Journal:  Drug Deliv Transl Res       Date:  2019-06       Impact factor: 4.617

9.  Study of the biological characteristics of human umbilical cord mesenchymal stem cells after long-time cryopreservation.

Authors:  Mingqi Zhang; Yan Zhao; Le Wang; Yuqiang Zheng; Hui Yu; Xiaoming Dong; Wei He; Zhengqin Yin; Zhuoshi Wang
Journal:  Cell Tissue Bank       Date:  2022-01-23       Impact factor: 1.522

Review 10.  The effects and potential applications of concentrated growth factor in dentin-pulp complex regeneration.

Authors:  Zixia Li; Liu Liu; Liu Wang; Dongzhe Song
Journal:  Stem Cell Res Ther       Date:  2021-06-19       Impact factor: 6.832
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