Dongmei Kang1, Quhua Yin2, Xiaoli Yan2, Huaidong Song3, Guanqi Gao4, Jun Liang5, Jiajun Zhao6. 1. Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021, Shandong, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical MedicineJinan 250021, Shandong, China; Department of Geriatrics, Anhui Provincial Hospital Affiliated to Anhui Medical UniversityHefei 230001, Anhui, China. 2. Department of Geriatrics, Anhui Provincial Hospital Affiliated to Anhui Medical University Hefei 230001, Anhui, China. 3. Department of Endocrinology, Ruijin Hospital Affiliated to SJTU School of Medicine, State Key Laboratory of Medical Genomics and Shanghai Institute of Endocrinology and Metabolism Shanghai 200025, China. 4. Department of Endocrinology, The People's Hospital of Linyi Linyi 276003, Shandong, China. 5. Department of Endocrinology, The Central Hospital of Xuzhou Affiliated to Xuzhou Medical College Xuzhou 221109, Jiangsu, China. 6. Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021, Shandong, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical MedicineJinan 250021, Shandong, China.
Abstract
OBJECTIVE: This study was designed to investigate serum cholesterol levels in middle-aged euthyroid subjects with positive thyroid peroxidase antibodies (TPOAbs). METHODS: We screened 1607 euthyroid subjects aged 35-65 years old. All the subjects were divided into 2 groups (i.e., TPOAb-positive group, n=205; TPOAb-negative group, n=1402) according to the level of TPOAb. The subjects were then subgrouped according to serum thyroid stimulating hormone (TSH) levels; those with a TSH level of 0.3-0.99 mIU/L, 1.0-1.89 mIU/L, and 1.9-4.80 mIU/L were classified into the low-normal, mid-range, and high-normal TSH subgroups, respectively). Each TSH group further subdivided into TPOAb-positive and TPOAb-negative subgroup. Data regarding the subjects' height, body weight, blood pressure, and levels of serum TSH, TPOAb, fasting plasma glucose, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) were collected. RESULTS: Compared with TPOAb-negative subjects, TPOAb-positive patients had higher levels of TSH, TC, and HDL-C (P=0.001, P=0.012, and P=0.049 respectively) with a tendency for increased LDL-C levels (P=0.053). In the low-normal TSH subgroup, subjects with and without TPOAb had similar levels of TSH, TC, HDL-C, and LDL-C (P>0.05). In mid-range TSH subgroup, TPOAb-positive patients had higher HDL-C levels compared to TPOAb-negative subjects (P=0.008) and a tendency for increased TC levels (P=0.121). In the high-normal TSH subgroup, TPOAb-positive patients had higher TSH and TC levels compared to TPOAb-negative subjects (P<0.001 and P=0.046 respectively). CONCLUSIONS: High TPOAb levels above the normal range appears in euthyroid population, dyslipidemia have begun.
OBJECTIVE: This study was designed to investigate serum cholesterol levels in middle-aged euthyroid subjects with positive thyroid peroxidase antibodies (TPOAbs). METHODS: We screened 1607 euthyroid subjects aged 35-65 years old. All the subjects were divided into 2 groups (i.e., TPOAb-positive group, n=205; TPOAb-negative group, n=1402) according to the level of TPOAb. The subjects were then subgrouped according to serum thyroid stimulating hormone (TSH) levels; those with a TSH level of 0.3-0.99 mIU/L, 1.0-1.89 mIU/L, and 1.9-4.80 mIU/L were classified into the low-normal, mid-range, and high-normal TSH subgroups, respectively). Each TSH group further subdivided into TPOAb-positive and TPOAb-negative subgroup. Data regarding the subjects' height, body weight, blood pressure, and levels of serum TSH, TPOAb, fasting plasma glucose, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) were collected. RESULTS: Compared with TPOAb-negative subjects, TPOAb-positive patients had higher levels of TSH, TC, and HDL-C (P=0.001, P=0.012, and P=0.049 respectively) with a tendency for increased LDL-C levels (P=0.053). In the low-normal TSH subgroup, subjects with and without TPOAb had similar levels of TSH, TC, HDL-C, and LDL-C (P>0.05). In mid-range TSH subgroup, TPOAb-positive patients had higher HDL-C levels compared to TPOAb-negative subjects (P=0.008) and a tendency for increased TC levels (P=0.121). In the high-normal TSH subgroup, TPOAb-positive patients had higher TSH and TC levels compared to TPOAb-negative subjects (P<0.001 and P=0.046 respectively). CONCLUSIONS: High TPOAb levels above the normal range appears in euthyroid population, dyslipidemia have begun.
Entities:
Keywords:
Thyroid peroxidase antibody; high density lipoprotein cholesterol; thyroid-stimulating hormone; total cholesterol
Authors: Zoltán Balogh; Gabriella Fóris; Gabriella Kónya; György Paragh; Tamás Köbling; János T Padra; Zsolt Sarang; György Paragh Journal: Immunobiology Date: 2010-08-12 Impact factor: 3.144
Authors: Robert S Rosenson; H Bryan Brewer; Benjamin Ansell; Philip Barter; M John Chapman; Jay W Heinecke; Anatol Kontush; Alan R Tall; Nancy R Webb Journal: Circulation Date: 2013-09-10 Impact factor: 29.690
Authors: Michael Miller; Neil J Stone; Christie Ballantyne; Vera Bittner; Michael H Criqui; Henry N Ginsberg; Anne Carol Goldberg; William James Howard; Marc S Jacobson; Penny M Kris-Etherton; Terry A Lennie; Moshe Levi; Theodore Mazzone; Subramanian Pennathur Journal: Circulation Date: 2011-04-18 Impact factor: 29.690
Authors: Elizabeth H Hoogendoorn; Ad R Hermus; Femmie de Vegt; H Alec Ross; Andre L M Verbeek; Lambertus A L M Kiemeney; Dorine W Swinkels; Fred C G J Sweep; Martin den Heijer Journal: Clin Chem Date: 2005-10-27 Impact factor: 8.327
Authors: Joseph G Hollowell; Norman W Staehling; W Dana Flanders; W Harry Hannon; Elaine W Gunter; Carole A Spencer; Lewis E Braverman Journal: J Clin Endocrinol Metab Date: 2002-02 Impact factor: 5.958
Authors: A Hernández-Mijares; A Jover; L Bellod; C Bañuls; E Solá; S Veses; V M Víctor; M Rocha Journal: Clin Endocrinol (Oxf) Date: 2013-05 Impact factor: 3.478