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Literature DB >> 26885026

Deregulation of decorin and FHL1 are associated with esophageal squamous cell carcinoma progression and poor prognosis.

Chunhua Ji¹, Hui Liu¹, Ming Xiang¹, Junjun Liu¹, Fengtao Yue¹, Weiqing Wang¹, Xiao Chu¹.

Abstract

To investigate the expression of FHL1 and Decorin in esophageal squamous cell carcinoma (ESCC) and its clinical significance. 82 ESCC tissues were evaluated by immunohistochemistry for the expression of FHL1 and Decorin. The role of the expression of FHL1 and Decorin in ESCC were statistically analyzed. The expression level of FHL1 and Decorin were reduced in malignant tissue samples in comparison to normal matched tissue (P < 0.05). It was also proved that the positive expressions of FHL1 and Decorin were associated with ESCC histological grade, lymph node metastasis, tumor stage and clinical stage (P < 0.05). In addition, the Kaplan-Meier survival curves revealed that the positive expressions of FHL1 and Decorin were associated with favorable prognosis in ESCC patients. Multivariate analysis showed that the positive expressions of FHL1 and Decorin were independent prognostic markers of overall survival of ESCC patients, respectively. The positive expressions of FHL1 and Decorin were associated with ESCC progression and good prognosis. Our results indicate that the positive expressions of FHL1 and Decorin were independent prognostic factors for patients with esophageal cancer, which might be potential valuable biomarkers for ESCC.

Entities: Disease Gene Species

Keywords: Decorin; FHL1; cancer biomarker; esophageal squamous cell carcinoma; prognosis

Year: 2015 PMID： 26885026 PMCID： PMC4723871

Source DB: PubMed Journal: Int J Clin Exp Med ISSN： 1940-5901

19 in total

1. Expression of FHL1 in gastric cancer tissue and its correlation with the invasion and metastasis of gastric cancer.

Authors: Yuanhong Xu; Zhe Liu; Kejian Guo
Journal: Mol Cell Biochem Date: 2011-12-06 Impact factor: 3.396

Review 2. Quantification of immunohistochemistry--issues concerning methods, utility and semiquantitative assessment I.

Authors: R A Walker
Journal: Histopathology Date: 2006-10 Impact factor: 5.087

3. Association of p53 expression with prognosis in patients with esophageal squamous cell carcinoma.

Authors: Wenjian Yao; Xiuguang Qin; Bo Qi; Jianguo Lu; Ling Guo; Fulei Liu; Shangguo Liu; Baosheng Zhao
Journal: Int J Clin Exp Pathol Date: 2014-09-15

4. Downregulation and growth inhibitory role of FHL1 in lung cancer.

Authors: Chang Niu; Chaoyang Liang; Juntang Guo; Long Cheng; Hao Zhang; Xi Qin; Qunwei Zhang; Lihua Ding; Bin Yuan; Xiaojie Xu; Jiezhi Li; Jing Lin; Qinong Ye
Journal: Int J Cancer Date: 2011-08-16 Impact factor: 7.396

5. Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice.

Authors: Xiuli Bi; Nicole M Pohl; Zhibin Qian; George R Yang; Yuan Gou; Grace Guzman; Andre Kajdacsy-Balla; Renato V Iozzo; Wancai Yang
Journal: Carcinogenesis Date: 2011-12-08 Impact factor: 4.944

6. Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays.

Authors: J Yang; C S Moravec; M A Sussman; N R DiPaola; D Fu; L Hawthorn; C A Mitchell; J B Young; G S Francis; P M McCarthy; M Bond
Journal: Circulation Date: 2000-12-19 Impact factor: 29.690

7. Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways.

Authors: Yunping Hu; Haiguo Sun; Rick T Owens; Jiansheng Wu; Yong Q Chen; Isabelle M Berquin; Donna Perry; Joseph T O'Flaherty; Iris J Edwards
Journal: Neoplasia Date: 2009-10 Impact factor: 5.715

8. A role for aberrantly expressed nuclear localized decorin in migration and invasion of dysplastic and malignant oral epithelial cells.

Authors: Nyla Dil; Abhijit G Banerjee
Journal: Head Neck Oncol Date: 2011-09-29

9. Expression and clinical significance of c-Met in advanced esophageal squamous cell carcinoma.

Authors: Yingying Xu; Zhi Peng; Zhongwu Li; Ming Lu; Jing Gao; Yilin Li; Yanyan Li; Lin Shen
Journal: BMC Cancer Date: 2015-01-15 Impact factor: 4.430

Review 10. Biological functions of decorin in cancer.

Authors: Xiu-Li Bi; Wancai Yang
Journal: Chin J Cancer Date: 2013-04-19

7 in total

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Authors: Qing-Yong Cai; Gui-You Liang; Yi-Feng Zheng; Qun-You Tan; Ru-Wen Wang; Kun Li
Journal: Am J Transl Res Date: 2017-07-15 Impact factor: 4.060

Review 2. Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways.

Authors: Christopher Xie; Dipon K Mondal; Mikdat Ulas; Thomas Neill; Renato V Iozzo
Journal: Am J Physiol Cell Physiol Date: 2022-02-16 Impact factor: 4.249

3. Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.

Authors: Qiankun Luo; Yanfeng Pan; Qiang Fu; Xu Zhang; Shuai Zhou; Pengfei Yu; Huiyuan Tian; Pan Liu; Song Chen; Hongwei Zhang; Tao Qin
Journal: Cell Biol Toxicol Date: 2022-02-10 Impact factor: 6.691