Literature DB >> 26884990

Acute promyelocytic leukemia transformation in a patient with aplastic anemia: a case report with literature review.

Xiaoning Wang1, Tingting Yuan2, Wenjuan Wang1, Limei Chen1, Huaiyu Wang1, Yalin Liu1.   

Abstract

Aplastic anemia (AA) is a hematological disorder presenting with pancytopenia in peripheral blood and hypocellularity in bone marrow. AA patients with immunosuppressive therapy and granulocyte colony-stimulating factor treatment have a risk of development of acute leukemia including acute myeloid leukemia (M0, M1, M2, M4, M5, M6) and acute lymphoblastic leukemia. However, AA with transformation to acute promyelocytic leukemia (APL) has never been reported. Here, we reported a patient initially diagnosed with AA. while 19 years later, PML/RAR αfusion gene were detected and the patient was eventually diagnosed as APL. The diagnosis and management of this interesting case are discussed.

Entities:  

Keywords:  Aplastic anemia; acute promyelocytic leukemia; immunosuppressive therapy

Year:  2015        PMID： 26884990      PMCID： PMC4723835     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  9 in total

1.  Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT).

Authors:  Gerard Socie; Jean-Yves Mary; Hubert Schrezenmeier; Judith Marsh; Andrea Bacigalupo; Anna Locasciulli; Monica Fuehrer; Albert Bekassy; Andre Tichelli; Jakob Passweg
Journal:  Blood       Date:  2007-04-01       Impact factor: 22.113

2.  Treatment of acquired aplastic anemia.

Authors:  Judith C W Marsh
Journal:  Haematologica       Date:  2007-01       Impact factor: 9.941

3.  A randomized controlled study in patients with newly diagnosed severe aplastic anemia receiving antithymocyte globulin (ATG), cyclosporine, with or without G-CSF: a study of the SAA Working Party of the European Group for Blood and Marrow Transplantation.

Authors:  André Tichelli; Hubert Schrezenmeier; Gérard Socié; Judith Marsh; Andrea Bacigalupo; Ulrich Dührsen; Anke Franzke; Michael Hallek; Eckhard Thiel; Martin Wilhelm; Britta Höchsmann; Alain Barrois; Kim Champion; Jakob R Passweg
Journal:  Blood       Date:  2011-01-13       Impact factor: 22.113

Review 4.  Recent developments in drug therapy for aplastic anemia.

Authors:  Lauren Willis; Amber Rexwinkle; Jeffrey Bryan; Tapan M Kadia
Journal:  Ann Pharmacother       Date:  2014-09-02       Impact factor: 3.154

5.  Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

Authors:  Tetsuichi Yoshizato; Bogdan Dumitriu; Kohei Hosokawa; Hideki Makishima; Kenichi Yoshida; Danielle Townsley; Aiko Sato-Otsubo; Yusuke Sato; Delong Liu; Hiromichi Suzuki; Colin O Wu; Yuichi Shiraishi; Michael J Clemente; Keisuke Kataoka; Yusuke Shiozawa; Yusuke Okuno; Kenichi Chiba; Hiroko Tanaka; Yasunobu Nagata; Takamasa Katagiri; Ayana Kon; Masashi Sanada; Phillip Scheinberg; Satoru Miyano; Jaroslaw P Maciejewski; Shinji Nakao; Neal S Young; Seishi Ogawa
Journal:  N Engl J Med       Date:  2015-07-02       Impact factor: 91.245

6.  Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.

Authors:  Phillip Scheinberg; James N Cooper; Elaine M Sloand; Colin O Wu; Rodrigo T Calado; Neal S Young
Journal:  JAMA       Date:  2010-09-22       Impact factor: 56.272

Review 7.  Riddle: what do aplastic anemia, acute promyelocytic leukemia, and chronic myeloid leukemia have in common?

Authors:  R A Brodsky; R J Jones
Journal:  Leukemia       Date:  2004-10       Impact factor: 11.528

8.  Risk factors for evolution of acquired aplastic anemia into myelodysplastic syndrome and acute myeloid leukemia after immunosuppressive therapy in children.

Authors:  Seiji Kojima; Akira Ohara; Masahiro Tsuchida; Toru Kudoh; Ryoji Hanada; Yuri Okimoto; Takashi Kaneko; Toshikuni Takano; Koichiro Ikuta; Ichiro Tsukimoto
Journal:  Blood       Date:  2002-08-01       Impact factor: 22.113

Review 9.  Aplastic anemia: pathophysiology and treatment.

Authors:  Neal S Young; Andrea Bacigalupo; Judith C W Marsh
Journal:  Biol Blood Marrow Transplant       Date:  2009-09-24       Impact factor: 5.742
  9 in total

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