OBJECTIVE: To explore the association between human cytomegalovirus (HCMV) and epilepsy. METHODS: Epilepsy patients (n = 112) in neurology clinic of our hospital during January 2012 and December 2014 were allocated to the case groups, including intractable epilepsy group (n = 96) and non-intractable epilepsy group (n = 16). Healthy individual (n = 120) who received physical examination during the same period were allocated to the control group. The expression of serum HCMV late gene pp67-RNA was detected by reverse transcription-polymerase chain reaction (RT-PCR). The expressions of serum HCMV immunoglobulin G (IgG), immunoglobulin M (IgM) and interleukin-6 (IL-6) were detected by enzyme-linked immunosorbent assay (ELISA). Serum hypersensitive c-reactive protein (hs-CRP) was detected by latex-enhanced immunoturbidimetry. The electroencephalogram (EEG) of refractory epilepsy group, non-refractory epilepsy group and control group were recorded. RESULTS: The expression of pp67-mRNA was significantly higher in intractable epilepsy group than non-intractable epilepsy group (P < 0.05) and control group (P < 0.001). The HCMV-IgG positive rate and HCMV-IgM positive rate were significantly higher in intractable epilepsy group than control group (both P < 0.001). The HCMV-IgM positive rate was significantly higher in intractable epilepsy group than non-intractable epilepsy group (P < 0.001). The HCMV-IgM positive rate was significantly higher in non-intractable epilepsy group than control group (P < 0.001). The hs-CRP and IL-6 levels presented descending trends respectively in intractable epilepsy group, non-intractable epilepsy group and control group (all P < 0.001). CONCLUSION: HCMV was prominently expressed in epilepsy and might contribute to the development of epilepsy.
OBJECTIVE: To explore the association between human cytomegalovirus (HCMV) and epilepsy. METHODS:Epilepsypatients (n = 112) in neurology clinic of our hospital during January 2012 and December 2014 were allocated to the case groups, including intractable epilepsy group (n = 96) and non-intractable epilepsy group (n = 16). Healthy individual (n = 120) who received physical examination during the same period were allocated to the control group. The expression of serum HCMV late gene pp67-RNA was detected by reverse transcription-polymerase chain reaction (RT-PCR). The expressions of serum HCMV immunoglobulin G (IgG), immunoglobulin M (IgM) and interleukin-6 (IL-6) were detected by enzyme-linked immunosorbent assay (ELISA). Serum hypersensitivec-reactive protein (hs-CRP) was detected by latex-enhanced immunoturbidimetry. The electroencephalogram (EEG) of refractory epilepsy group, non-refractory epilepsy group and control group were recorded. RESULTS: The expression of pp67-mRNA was significantly higher in intractable epilepsy group than non-intractable epilepsy group (P < 0.05) and control group (P < 0.001). The HCMV-IgG positive rate and HCMV-IgM positive rate were significantly higher in intractable epilepsy group than control group (both P < 0.001). The HCMV-IgM positive rate was significantly higher in intractable epilepsy group than non-intractable epilepsy group (P < 0.001). The HCMV-IgM positive rate was significantly higher in non-intractable epilepsy group than control group (P < 0.001). The hs-CRP and IL-6 levels presented descending trends respectively in intractable epilepsy group, non-intractable epilepsy group and control group (all P < 0.001). CONCLUSION:HCMV was prominently expressed in epilepsy and might contribute to the development of epilepsy.
Authors: H M González-Sánchez; A Monsiváis-Urenda; C A Salazar-Aldrete; A Hernández-Salinas; D E Noyola; M E Jiménez-Capdeville; A Martínez-Serrano; C G Castillo Journal: J Neurovirol Date: 2015-04-08 Impact factor: 2.643
Authors: H Hebart; C Lengerke; P Ljungman; C V Paya; T Klingebiel; J Loeffler; S Pfaffenrath; I Lewensohn-Fuchs; L Barkholt; J Tomiuk; C Meisner; J Lunenberg; B Top; R R Razonable; R Patel; M R Litzow; G Jahn; H Einsele Journal: Bone Marrow Transplant Date: 2010-06-28 Impact factor: 5.483
Authors: Ismini E Papageorgiou; Andriani F Fetani; Andrea Lewen; Uwe Heinemann; Oliver Kann Journal: Brain Struct Funct Date: 2014-05-31 Impact factor: 3.270