Zheng Zeng1, Bing Wang1, Haitao Pan1. 1. Department of Orthopaedic Surgery, Beijing Tian Tan Hospital, Capital Medical University 100050, China.
Abstract
OBJECTIVE: The aim of this study was to investigate the association of plasminogen activator inhibitor-1 (PAI-1) 4G/5G gene polymorphism and osteonecrosis of the femoral head (ONFH). METHODS: The pooled relative risk ratio (RR) and 95% confidence intervals (95% CI) were calculated using the the RevMan 5.0 software. RESULTS: The present study included 969 patients with ONFH and 419 healthy controls. The Meta analysis results showed: There is association between PAI-1 gene 4G/5G polymorphism and the increasing risk of ONFH (allele model: RR = 1.24, 95% CI = 1.16 ~ 1.33; dominant genetic model: RR = 1.12, 95% CI = 1.05 ~ 1.18). It was found that the association between PAI-1 gene 4 G/5 G polymorphism and the susceptibility of ONFH (P < 0.05) through the comparison of Caucasian population and Asian people according to the analysis of different races. CONCLUSIONS: There is association between PAI-1 gene 4 G/5 G polymorphism and the increasing of the susceptibility of ONFH.
OBJECTIVE: The aim of this study was to investigate the association of plasminogen activator inhibitor-1 (PAI-1) 4G/5G gene polymorphism and osteonecrosis of the femoral head (ONFH). METHODS: The pooled relative risk ratio (RR) and 95% confidence intervals (95% CI) were calculated using the the RevMan 5.0 software. RESULTS: The present study included 969 patients with ONFH and 419 healthy controls. The Meta analysis results showed: There is association between PAI-1 gene 4G/5G polymorphism and the increasing risk of ONFH (allele model: RR = 1.24, 95% CI = 1.16 ~ 1.33; dominant genetic model: RR = 1.12, 95% CI = 1.05 ~ 1.18). It was found that the association between PAI-1 gene 4 G/5 G polymorphism and the susceptibility of ONFH (P < 0.05) through the comparison of Caucasian population and Asian people according to the analysis of different races. CONCLUSIONS: There is association between PAI-1 gene 4 G/5 G polymorphism and the increasing of the susceptibility of ONFH.
Entities:
Keywords:
Plasminogen activator inhibitor-1; meta-analysis; osteonecrosis of the femoral head
Authors: K W Klinger; R Winqvist; A Riccio; P A Andreasen; R Sartorio; L S Nielsen; N Stuart; P Stanislovitis; P Watkins; R Douglas Journal: Proc Natl Acad Sci U S A Date: 1987-12 Impact factor: 11.205