Hypersensitivity reactions to human seminal plasma.

A rare but serious allergic reaction has been described. Human seminal plasma hypersensitivity predominantly occurs in young women possibly as a result of altered immune status involving the reproductive organs. The patients generally have a history of atopy and, in typical cases, immunologic tests corroborate a reaginic humoral mechanism. Fortunately, there is considerable evidence that selected patients can be successfully treated with selective immunotherapy. Alternatively, the application of topical cromolyn holds promise for successful prevention of symptoms.