Jun Dong1, Li Tian2, Sheng Li2, Yunxian Mo2, Lizhi Liu2, Rui Zhong2. 1. Department of VIP Patients, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine East Dong Feng Road 651, Guangzhou 510060, Guangdong, P. R. China. 2. Department of Medical Imaging and Interventional Radiology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine East Dong Feng Road 651, Guangzhou 510060, Guangdong, P. R. China.
Abstract
OBJECTIVE: This study aimed to map differences in extension patterns between adenoid cystic carcinoma (ACC) of the nasopharynxandnasopharyngeal carcinomaon magnetic resonance imaging (MRI) and provide more information for treatments. METHODS: MRI examinations and clinical records were reviewed in 18 patients with ACC of the nasopharynx and 182 patients with nasopharyngeal carcinoma (NPC). All patients had biopsy to confirm diagnosis. Differences between NPC and ACC in terms of extension patterns were identified by the retrospective analysis of images from patients undergoing MRI. RESULTS: Patients with ACC of the nasopharynx obtained a higher rate of staging T4 (14.3% vs. 38.9%, P = 0.007) and paralyzed cranial nerves (6.0% vs. 38.9%, P < 0.001). Epstein-Barr (EB) virus infection was not correlated with ACC incidence. No significant difference was observed in invasion to skull base between ACC of the nasopharynx and NPC (53.3% vs. 66.7%, P = 0.277). Involvement of cranial nerve canal (32.4% vs. 55.6%, P = 0.049) and cavernous sinus (13.7% vs. 33.3%, P = 0.028) was more frequently detected by MRI on patients with ACC of the nasopharynx. Lymph node metastasis was infrequently diagnosed in patients with ACC of the nasopharynx. CONCLUSION: As seen on MRI images, ACC of the nasopharynx is characterized by a high incidence of perineural invasion, frequent and aggressive local infiltration, and infrequently, lymph node metastasis.
OBJECTIVE: This study aimed to map differences in extension patterns between adenoid cystic carcinoma (ACC) of the nasopharynxandnasopharyngeal carcinomaon magnetic resonance imaging (MRI) and provide more information for treatments. METHODS: MRI examinations and clinical records were reviewed in 18 patients with ACC of the nasopharynx and 182 patients with nasopharyngeal carcinoma (NPC). All patients had biopsy to confirm diagnosis. Differences between NPC and ACC in terms of extension patterns were identified by the retrospective analysis of images from patients undergoing MRI. RESULTS:Patients with ACC of the nasopharynx obtained a higher rate of staging T4 (14.3% vs. 38.9%, P = 0.007) and paralyzed cranial nerves (6.0% vs. 38.9%, P < 0.001). Epstein-Barr (EB) virus infection was not correlated with ACC incidence. No significant difference was observed in invasion to skull base between ACC of the nasopharynx and NPC (53.3% vs. 66.7%, P = 0.277). Involvement of cranial nerve canal (32.4% vs. 55.6%, P = 0.049) and cavernous sinus (13.7% vs. 33.3%, P = 0.028) was more frequently detected by MRI on patients with ACC of the nasopharynx. Lymph node metastasis was infrequently diagnosed in patients with ACC of the nasopharynx. CONCLUSION: As seen on MRI images, ACC of the nasopharynx is characterized by a high incidence of perineural invasion, frequent and aggressive local infiltration, and infrequently, lymph node metastasis.
Authors: Dawn P Liew; Manuel Röhrich; Lisa Loi; Sebastian Adeberg; Mustafa Syed; Ewgenija Gutjahr; Heinz Peter Schlemmer; Frederik L Giesel; Martin Bendszus; Uwe Haberkorn; Daniel Paech Journal: Cancers (Basel) Date: 2022-08-31 Impact factor: 6.575