Literature DB >> 26884847

Mechanism of bile acid-regulated glucose and lipid metabolism in duodenal-jejunal bypass.

Jie Chai1, Lei Zou1, Xirui Li1, Dali Han1, Shan Wang1, Sanyuan Hu2, Jie Guan1.   

Abstract

Bile acid plays an important role in regulating blood glucose, lipid and energy metabolism. The present study was implemented to determine the effect of duodenal-jejunal bypass (DJB) on FXR, TGR-5expression in terminal ileum and its bile acid-related mechanism on glucose and lipid metabolism. Immunohistochemistry was used to detect relative gene or protein expression in liver and intestine. Firstly, we found that expression of FXR in liver and terminal ileum of DJB group was significantly higher than that in S-DJB group (P<0.05). In addition, DJB dramatically increased the activation of TGR-5 in the liver of rats. Furthermore, PEPCK, G6Pase, FBPase 1 and GLP-1 were up-regulated by DJB. In conclusion, these results showed that bile acid ameliorated glucose and lipid metabolism through bile acid-FXR and bile acid- TGR-5 signaling pathway.

Entities:  

Keywords:  Duodenal-jejunal bypass; FXR; TGR-5; bile acid

Mesh：

Substances：

Year:  2015        PMID： 26884847      PMCID： PMC4730060     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  30 in total

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