Young Eun Huh1, Seonhong Hwang2, Keehoon Kim3, Won-Ho Chung4, Jinyoung Youn5, Jin Whan Cho6. 1. Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea. Electronic address: nana1880@hanmail.net. 2. Center for Robotics Research, Korea Institute of Science and Technology, Seoul, South Korea. Electronic address: sh@kist.re.kr. 3. Center for Robotics Research, Korea Institute of Science and Technology, Seoul, South Korea. Electronic address: khk@kist.re.kr. 4. Department of Otolaryngology, Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea. Electronic address: wonho.chung@samsung.com. 5. Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea; Neuroscience Center, Samsung Medical Center, Seoul, South Korea. Electronic address: genian.youn@samsung.com. 6. Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea; Neuroscience Center, Samsung Medical Center, Seoul, South Korea. Electronic address: jinwhan.cho@samsung.com.
Abstract
INTRODUCTION: To elucidate the unique patterns of postural sensory deficits contributing to freezing of gait (FOG) in patients with Parkinson's disease (PD) and to identify postural sensory modalities that correlate with FOG severity. METHODS: Twenty-five PD patients with FOG, 22 PD patients without FOG, and 26 age-matched controls were evaluated using a sensory organization test and clinical measures including the Unified Parkinson's Disease Rating Scale motor score, Montreal Cognitive Assessment, Frontal Assessment Battery, Activities-specific Balance Confidence, Beck Anxiety Inventory, Beck Depression Inventory, and Berg Balance Scale. Multivariable logistic regression analysis was performed for posturographic parameters and possible confounders to determine postural sensory contributors to FOG. We also correlated FOG severity, measured using a New Freezing of Gait Questionnaire, with posturographic parameters. RESULTS: PD patients with FOG showed worse postural sensory processing compared with those without FOG. In particular, the inability to use the vestibular information (odds ratio [OR] 1.447; 95% confidential interval [CI]: 1.120, 1.869) and poor control over the perturbed somatosensory inputs (OR 2.904; 95% CI: 1.028, 8.202) significantly contributed to FOG. Among PD patients with FOG, FOG severity was correlated with higher reliance on visual information (ρ = -0.432, p = 0.039). CONCLUSIONS: Postural sensory deficits involving specific sensory modalities are strongly associated with FOG. Quantitative measurement of postural sensory deficits in PD patients with FOG may provide a better understanding of pathomechanisms of FOG and increase the efficacy of sensory cueing strategies for alleviating FOG, by more accurately identifying suitable patients for rehabilitative therapies.
INTRODUCTION: To elucidate the unique patterns of postural sensory deficits contributing to freezing of gait (FOG) in patients with Parkinson's disease (PD) and to identify postural sensory modalities that correlate with FOG severity. METHODS: Twenty-five PDpatients with FOG, 22 PDpatients without FOG, and 26 age-matched controls were evaluated using a sensory organization test and clinical measures including the Unified Parkinson's Disease Rating Scale motor score, Montreal Cognitive Assessment, Frontal Assessment Battery, Activities-specific Balance Confidence, Beck Anxiety Inventory, Beck Depression Inventory, and Berg Balance Scale. Multivariable logistic regression analysis was performed for posturographic parameters and possible confounders to determine postural sensory contributors to FOG. We also correlated FOG severity, measured using a New Freezing of Gait Questionnaire, with posturographic parameters. RESULTS:PDpatients with FOG showed worse postural sensory processing compared with those without FOG. In particular, the inability to use the vestibular information (odds ratio [OR] 1.447; 95% confidential interval [CI]: 1.120, 1.869) and poor control over the perturbed somatosensory inputs (OR 2.904; 95% CI: 1.028, 8.202) significantly contributed to FOG. Among PDpatients with FOG, FOG severity was correlated with higher reliance on visual information (ρ = -0.432, p = 0.039). CONCLUSIONS:Postural sensory deficits involving specific sensory modalities are strongly associated with FOG. Quantitative measurement of postural sensory deficits in PDpatients with FOG may provide a better understanding of pathomechanisms of FOG and increase the efficacy of sensory cueing strategies for alleviating FOG, by more accurately identifying suitable patients for rehabilitative therapies.
Authors: Daniel Weiss; Anna Schoellmann; Michael D Fox; Nicolaas I Bohnen; Stewart A Factor; Alice Nieuwboer; Mark Hallett; Simon J G Lewis Journal: Brain Date: 2020-01-01 Impact factor: 13.501
Authors: Jose Ivo A Beserra-Filho; Amanda Maria-Macêdo; Suellen Silva-Martins; Ana Cláudia Custódio-Silva; Beatriz Soares-Silva; Sara Pereira Silva; Rafael Herling Lambertucci; Adriano Antunes de Souza Araújo; Angélica Maria Lucchese; Lucindo J Quintans-Júnior; José Ronaldo Santos; Regina H Silva; Alessandra M Ribeiro Journal: Metab Brain Dis Date: 2022-07-02 Impact factor: 3.655
Authors: Victor Schwartz Hvingelby; Andreas Nørgaard Glud; Jens Christian Hedemann Sørensen; Yen Tai; Anne Sofie Møller Andersen; Erik Johnsen; Elena Moro; Nicola Pavese Journal: J Neurol Date: 2022-04-05 Impact factor: 6.682