| Literature DB >> 26883144 |
Kedong Song1, Liying Li2, Yiwei Wang3, Tianqing Liu2.
Abstract
Hematopoietic stem cells (HSCs) are capable to self-renew with multi-potency which generated much excitement in clinical therapy. However, the main obstacle of HSCs in clinical application was insufficient number of HSCs which were derived from either bone marrow, peripheral blood or umbilical cord blood. This review briefly discusses the indispensable utility of growth factors and cytokines, stromal cells, extracellular matrix, bionic scaffold and microenvironment aiming to control the hematopoiesis in all directions and provide a better and comprehensive understanding for in vitro expansion of hematopoietic stem cells.Entities:
Keywords: Ex vivo expansion; Hematopoietic stem cells (HSCs); Multiparameter regulation
Mesh:
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Year: 2016 PMID: 26883144 DOI: 10.1007/s13577-016-0134-x
Source DB: PubMed Journal: Hum Cell ISSN: 0914-7470 Impact factor: 4.174