| Literature DB >> 26882174 |
Jingqian Jiang1, Varsha Kanabar, Beatriz Padilla, Francis Man, Simon C Pitchford, Clive P Page, Gerd K Wagner.
Abstract
We report 5-substituted uridine derivatives as novel, uncharged inhibitors of β-1,4-galactosyltransferase and chemical tools for cellular applications. The new inhibitors reduce P-selectin glycoprotein 1 (PSGL-1) expression in human monocytes. Our results also provide novel insights into a unique mode of glycosyltransferase inhibition.Entities:
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Year: 2016 PMID： 26882174 DOI： 10.1039/c5cc09289b
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222