Literature DB >> 26880591

Microwave-assisted Synthesis and antifungal activity of coumarin[8,7-e][1,3]oxazine derivatives.

Ming-Zhi Zhang1, Rong-Rong Zhang1, Wen-Zheng Yin1, Xiang Yu1, Ya-Ling Zhang1, Pin Liu1, Yu-Cheng Gu2, Wei-Hua Zhang3.   

Abstract

The synthesis of novel coumarin[8,7-e][1,3]oxazine derivatives through a microwave-assisted three-component one-pot Mannich reaction is described in this study. All the target compounds were evaluated in vitro for their antifungal activity against Botrytis cinerea, Colletotrichum capsici, Alternaria solani, Gibberella zeae, Rhizoctonia solani, and Alternaria mali. The preliminary bioassays showed that 5e, 5m, and 5s exhibited good antifungal activity and the most active compound was 5m with an [Formula: see text] value as low as 2.1 nM against Botrytis cinerea.

Entities:  

Keywords:  Antifungal activity; Coumarin; Mannich reaction; Microwave-assisted synthesis; Oxazine; SAR

Mesh：

Substances：

Year:  2016        PMID： 26880591     DOI： 10.1007/s11030-016-9662-2

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  16 in total

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Review 2.  Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol.

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Journal:  Curr Med Chem       Date:  2006       Impact factor: 4.530

4.  Efficient Approach To Discover Novel Agrochemical Candidates: Intermediate Derivatization Method.

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Journal:  J Agric Food Chem       Date:  2015-01-05       Impact factor: 5.279

Review 5.  Application of the intermediate derivatization approach in agrochemical discovery.

Authors:  Aiying Guan; Changling Liu; Xiaoping Yang; Mark Dekeyser
Journal:  Chem Rev       Date:  2014-05-29       Impact factor: 60.622

6.  Identification and quantification of coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS.

Authors:  Sylvia Vogl; Martin Zehl; Paolo Picker; Ernst Urban; Christoph Wawrosch; Gottfried Reznicek; Johannes Saukel; Brigitte Kopp
Journal:  J Agric Food Chem       Date:  2011-03-22       Impact factor: 5.279

7.  Synthesis and antiinflammatory activity of coumarin derivatives.

Authors:  Christos A Kontogiorgis; Dimitra J Hadjipavlou-Litina
Journal:  J Med Chem       Date:  2005-10-06       Impact factor: 7.446

Review 8.  Systematic overview of warfarin and its drug and food interactions.

Authors:  Anne M Holbrook; Jennifer A Pereira; Renee Labiris; Heather McDonald; James D Douketis; Mark Crowther; Philip S Wells
Journal:  Arch Intern Med       Date:  2005-05-23

9.  Preparative isolation of osthol and xanthotoxol from Common Cnidium Fruit (Chinese traditional herb) using stepwise elution by high-speed counter-current chromatography.

Authors:  Yun Wei; Tianyou Zhang; Yoichiro Ito
Journal:  J Chromatogr A       Date:  2004-04-16       Impact factor: 4.759

Review 10.  Coumarins: old compounds with novel promising therapeutic perspectives.

Authors:  M E Riveiro; N De Kimpe; A Moglioni; R Vázquez; F Monczor; C Shayo; C Davio
Journal:  Curr Med Chem       Date:  2010       Impact factor: 4.530
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  4 in total

1.  Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives.

Authors:  Shu-Guang Zhang; Chao-Gen Liang; Yue-Qing Sun; Peng Teng; Jia-Qun Wang; Wei-Hua Zhang
Journal:  Mol Divers       Date:  2019-01-29       Impact factor: 2.943

2.  Dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-4-ones as a new class of CK2 inhibitors.

Authors:  Mykola V Protopopov; Olga V Ostrynska; Sergiy A Starosyla; Maria A Vodolazhenko; Svetlana M Sirko; Nikolay Yu Gorobets; Volodymyr Bdzhola; Sergey M Desenko; Sergiy M Yarmoluk
Journal:  Mol Divers       Date:  2018-05-29       Impact factor: 2.943

Review 3.  Molecular Insights into Coumarin Analogues as Antimicrobial Agents: Recent Developments in Drug Discovery.

Authors:  Rameshwar S Cheke; Harun M Patel; Vaishali M Patil; Iqrar Ahmad Ansari; Jaya P Ambhore; Sachin D Shinde; Adel Kadri; Mejdi Snoussi; Mohd Adnan; Prashant S Kharkar; Visweswara Rao Pasupuleti; Prashant K Deshmukh
Journal:  Antibiotics (Basel)       Date:  2022-04-24

4.  Design, Synthesis and Antifungal Activity of Psoralen Derivatives.

Authors:  Xiang Yu; Ya Wen; Chao-Gen Liang; Jia Liu; Yu-Bin Ding; Wei-Hua Zhang
Journal:  Molecules       Date:  2017-10-09       Impact factor: 4.411
  4 in total

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