Anne-Laure Betegnie1, Aurélie Gauchet1, Audrey Lehmann1, Laurent Grange1, Matthieu Roustit1, Magalie Baudrant1, Pierrick Bedouch1, Benoît Allenet2. 1. From the Pharmacy Department, University Hospital; Interuniversity Laboratory of Psychology: Personality, Cognition, Social Change (LIP/PC2S), University Grenoble-Alpes; Rheumatology Clinic, and Clinical Research Center, Grenoble University Hospital; University Grenoble-Alpes/Centre National de la Recherche Scientifique (CNRS)/Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble Unité Mixte de Recherche CNRS #5525 (TIMC-IMAG UMR 5525)/Themas, Grenoble, France.A.L. Betegnie, PharmD, Pharmacy Department, University Hospital; A. Gauchet, MS, PhD, LIP/PC2S, University Grenoble-Alpes; A. Lehmann, PharmD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; L. Grange, MD, PhD, Rheumatology Clinic, Grenoble University Hospital; M. Roustit, PharmD, PhD, Clinical Research Center, Grenoble University Hospital; M. Baudrant, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; P. Bedouch, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; B. Allenet, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas. 2. From the Pharmacy Department, University Hospital; Interuniversity Laboratory of Psychology: Personality, Cognition, Social Change (LIP/PC2S), University Grenoble-Alpes; Rheumatology Clinic, and Clinical Research Center, Grenoble University Hospital; University Grenoble-Alpes/Centre National de la Recherche Scientifique (CNRS)/Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble Unité Mixte de Recherche CNRS #5525 (TIMC-IMAG UMR 5525)/Themas, Grenoble, France.A.L. Betegnie, PharmD, Pharmacy Department, University Hospital; A. Gauchet, MS, PhD, LIP/PC2S, University Grenoble-Alpes; A. Lehmann, PharmD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; L. Grange, MD, PhD, Rheumatology Clinic, Grenoble University Hospital; M. Roustit, PharmD, PhD, Clinical Research Center, Grenoble University Hospital; M. Baudrant, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; P. Bedouch, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas; B. Allenet, PharmD, PhD, Pharmacy Department, University Hospital, and the University Grenoble-Alpes/CNRS/TIMC-IMAG UMR 5525/Themas. BAllenet@chu-grenoble.fr.
Abstract
OBJECTIVE: Concerns have been raised about nonadherence behavior among patients with chronic inflammatory rheumatic diseases (CIRD) receiving biologics. This nonadherence may be caused by various factors. The main objective was to explain why patients discontinue their biologics of their own accord. METHODS: A quantitative and descriptive study was performed using a self-report questionnaire that was sent through the Internet to members of different patient associations. Sociodemographic data, medical and therapeutic history, management of biologic administration, previous experiences, and patients' beliefs and perceptions about treatment efficacy and side effects were studied to explain self-discontinuation (SD). RESULTS: A total of 581 patients answered the questionnaire between June 16, 2012, and July 4, 2012, including patients with ankylosing spondylitis (351/581, 60.4%), rheumatoid arthritis (196/581, 33.7%), psoriatic arthritis (30/581, 5.2%), and other CIRD (4/581, 0.7%). More than 1000 different biologics were described by the 581 patients, with a median of 2 lines per patient. Eighty-six patients discontinued their biologics of their own accord (14.8%). In a multivariate analysis, factors that were significantly related to SD were low level of pain, more than 1 line of biologics tried, self-administration of biologics, negative beliefs about the treatment, and a lack of medical and social support. CONCLUSION: Five predictive factors of this SD were identified, which should be assessed in routine with patients with CIRD receiving biologic treatment: pain, treatment history, self-administration of injections, negative beliefs about treatment, and a lack of perceived medical and social support.
OBJECTIVE: Concerns have been raised about nonadherence behavior among patients with chronic inflammatory rheumatic diseases (CIRD) receiving biologics. This nonadherence may be caused by various factors. The main objective was to explain why patients discontinue their biologics of their own accord. METHODS: A quantitative and descriptive study was performed using a self-report questionnaire that was sent through the Internet to members of different patient associations. Sociodemographic data, medical and therapeutic history, management of biologic administration, previous experiences, and patients' beliefs and perceptions about treatment efficacy and side effects were studied to explain self-discontinuation (SD). RESULTS: A total of 581 patients answered the questionnaire between June 16, 2012, and July 4, 2012, including patients with ankylosing spondylitis (351/581, 60.4%), rheumatoid arthritis (196/581, 33.7%), psoriatic arthritis (30/581, 5.2%), and other CIRD (4/581, 0.7%). More than 1000 different biologics were described by the 581 patients, with a median of 2 lines per patient. Eighty-six patients discontinued their biologics of their own accord (14.8%). In a multivariate analysis, factors that were significantly related to SD were low level of pain, more than 1 line of biologics tried, self-administration of biologics, negative beliefs about the treatment, and a lack of medical and social support. CONCLUSION: Five predictive factors of this SD were identified, which should be assessed in routine with patients with CIRD receiving biologic treatment: pain, treatment history, self-administration of injections, negative beliefs about treatment, and a lack of perceived medical and social support.
Authors: Eldin Dzubur; Carine Khalil; Christopher V Almario; Benjamin Noah; Deeba Minhas; Mariko Ishimori; Corey Arnold; Yujin Park; Jonathan Kay; Michael H Weisman; Brennan M R Spiegel Journal: Arthritis Care Res (Hoboken) Date: 2019-02 Impact factor: 4.794
Authors: Josef S Smolen; Dafna Gladman; H Patrick McNeil; Philip J Mease; Joachim Sieper; Maja Hojnik; Pascal Nurwakagari; John Weinman Journal: RMD Open Date: 2019-01-11