Literature DB >> 26878841

A newly discovered flavivirus in the yellow fever virus group displays restricted replication in vertebrates.

Agathe M G Colmant1, Helle Bielefeldt-Ohmann1, Jody Hobson-Peters1, Willy W Suen1, Caitlin A O'Brien1, Andrew F van den Hurk2, Roy A Hall1.   

Abstract

A novel flavivirus, provisionally named Bamaga virus (BgV), was isolated from Culex annulirostris mosquitoes collected from northern Australia. Phylogenetic analysis of the complete nucleotide sequence of the BgV genome revealed it clustered with the yellow fever virus (YFV) group, and was most closely related to Edge Hill virus (EHV), another Australian flavivirus, with 61.9 % nucleotide and 63.7 % amino acid sequence identity. Antigenic analysis of the envelope and pre-membrane proteins of BgV further revealed epitopes common to EHV, dengue and other mosquito-borne flaviviruses. However, in contrast to these viruses, BgV displayed restricted growth in a range of vertebrate cell lines with no or relatively slow replication in inoculated cultures. There was also restricted BgV replication in virus-challenged mice. Our results indicate that BgV is an evolutionary divergent member of the YFV group of flaviviruses, and represents a novel system to study mechanisms of virus host-restriction and transmission.

Entities:  

Year:  2016        PMID： 26878841     DOI： 10.1099/jgv.0.000430

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  12 in total

Review 1.  Commensal Viruses of Mosquitoes: Host Restriction, Transmission, and Interaction with Arboviral Pathogens.

Authors:  Roy A Hall; Helle Bielefeldt-Ohmann; Breeanna J McLean; Caitlin A O'Brien; Agathe M G Colmant; Thisun B H Piyasena; Jessica J Harrison; Natalee D Newton; Ross T Barnard; Natalie A Prow; Joshua M Deerain; Marcus G K Y Mah; Jody Hobson-Peters
Journal:  Evol Bioinform Online       Date:  2017-01-10       Impact factor: 1.625

2.  A New Clade of Insect-Specific Flaviviruses from Australian Anopheles Mosquitoes Displays Species-Specific Host Restriction.

Authors:  Agathe M G Colmant; Jody Hobson-Peters; Helle Bielefeldt-Ohmann; Andrew F van den Hurk; Sonja Hall-Mendelin; Weng Kong Chow; Cheryl A Johansen; Jelke Fros; Peter Simmonds; Daniel Watterson; Chris Cazier; Kayvan Etebari; Sassan Asgari; Benjamin L Schulz; Nigel Beebe; Laura J Vet; Thisun B H Piyasena; Hong-Duyen Nguyen; Ross T Barnard; Roy A Hall
Journal:  mSphere       Date:  2017-07-12       Impact factor: 4.389

3.  Antigenic Characterization of New Lineage II Insect-Specific Flaviviruses in Australian Mosquitoes and Identification of Host Restriction Factors.

Authors:  Jessica J Harrison; Jody Hobson-Peters; Agathe M G Colmant; Joanna Koh; Natalee D Newton; David Warrilow; Helle Bielefeldt-Ohmann; Thisun B H Piyasena; Caitlin A O'Brien; Laura J Vet; Devina Paramitha; James R Potter; Steven S Davis; Cheryl A Johansen; Yin Xiang Setoh; Alexander A Khromykh; Roy A Hall
Journal:  mSphere       Date:  2020-06-17       Impact factor: 4.389

Review 4.  Exploiting the Legacy of the Arbovirus Hunters.

Authors:  Nikos Vasilakis; Robert B Tesh; Vsevolod L Popov; Steve G Widen; Thomas G Wood; Naomi L Forrester; Jean Paul Gonzalez; Jean Francois Saluzzo; Sergey Alkhovsky; Sai Kit Lam; John S Mackenzie; Peter J Walker
Journal:  Viruses       Date:  2019-05-23       Impact factor: 5.048

5.  Mosquito-Independent Transmission of West Nile virus in Farmed Saltwater Crocodiles (Crocodylus porosus).

Authors:  Gervais Habarugira; Jasmin Moran; Agathe M G Colmant; Steven S Davis; Caitlin A O'Brien; Sonja Hall-Mendelin; Jamie McMahon; Glen Hewitson; Neelima Nair; Jean Barcelon; Willy W Suen; Lorna Melville; Jody Hobson-Peters; Roy A Hall; Sally R Isberg; Helle Bielefeldt-Ohmann
Journal:  Viruses       Date:  2020-02-11       Impact factor: 5.048

6.  Neglected Australian Arboviruses and Undifferentiated Febrile Illness: Addressing Public Health Challenges Arising From the 'Developing Northern Australia' Government Policy.

Authors:  Narayan Gyawali; Richard S Bradbury; John G Aaskov; Andrew W Taylor-Robinson
Journal:  Front Microbiol       Date:  2017-11-07       Impact factor: 5.640

7.  Confronting the Emerging Threat to Public Health in Northern Australia of Neglected Indigenous Arboviruses.

Authors:  Narayan Gyawali; Andrew W Taylor-Robinson
Journal:  Trop Med Infect Dis       Date:  2017-10-17

8.  The recently identified flavivirus Bamaga virus is transmitted horizontally by Culex mosquitoes and interferes with West Nile virus replication in vitro and transmission in vivo.

Authors:  Agathe M G Colmant; Sonja Hall-Mendelin; Scott A Ritchie; Helle Bielefeldt-Ohmann; Jessica J Harrison; Natalee D Newton; Caitlin A O'Brien; Chris Cazier; Cheryl A Johansen; Jody Hobson-Peters; Roy A Hall; Andrew F van den Hurk
Journal:  PLoS Negl Trop Dis       Date:  2018-10-24

9.  NS4/5 mutations enhance flavivirus Bamaga virus infectivity and pathogenicity in vitro and in vivo.

Authors:  Agathe M G Colmant; Helle Bielefeldt-Ohmann; Laura J Vet; Caitlin A O'Brien; Richard A Bowen; Airn E Hartwig; Steven Davis; Thisun B H Piyasena; Gervais Habarugira; Jessica J Harrison; Jody Hobson-Peters; Roy A Hall
Journal:  PLoS Negl Trop Dis       Date:  2020-03-23

Review 10.  Understanding the Mechanisms Underlying Host Restriction of Insect-Specific Viruses.

Authors:  Ahmed Me Elrefaey; Rana Abdelnabi; Ana Lucia Rosales Rosas; Lanjiao Wang; Sanjay Basu; Leen Delang
Journal:  Viruses       Date:  2020-08-31       Impact factor: 5.048
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