| Literature DB >> 26876744 |
D Hungerford1, J M Read2, R P D Cooke3, R Vivancos4, M Iturriza-Gómara5, D J Allen6, N French5, N Cunliffe7.
Abstract
The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.Entities:
Keywords: Epidemiology; Healthcare-associated infection; Rotavirus; Vaccination
Mesh:
Substances:
Year: 2015 PMID: 26876744 DOI: 10.1016/j.jhin.2015.12.010
Source DB: PubMed Journal: J Hosp Infect ISSN: 0195-6701 Impact factor: 3.926