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Literature DB >> 26876477

Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies.

Matthew Devall¹, Janou Roubroeks², Jonathan Mill³, Michael Weedon¹, Katie Lunnon⁴.

Abstract

The field of mitochondrial epigenetics has received increased attention in recent years and changes in mitochondrial DNA (mtDNA) methylation has been implicated in a number of diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis. However, current publications have been limited by the use of global or targeted methods of measuring DNA methylation. In this review, we discuss current findings in mitochondrial epigenetics as well as its potential role as a regulator of mitochondria within the brain. Finally, we summarize the current technologies best suited to capturing mtDNA methylation, and how a move towards whole epigenome sequencing of mtDNA may help to advance our current understanding of the field.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: AD; Alzheimer's disease; DNA methylation; Epigenetics; Mitochondria; mtDNA

Mesh：

Substances：
DNA, Mitochondrial

Year: 2016 PMID： 26876477 PMCID： PMC5747527 DOI： 10.1016/j.neulet.2016.02.013

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

64 in total

1. Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture.

Authors: D T W Chang; I J Reynolds
Journal: Neuroscience Date: 2006-06-23 Impact factor: 3.590

2. Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells. In vivo and in vitro methylation.

Authors: M M Nass
Journal: J Mol Biol Date: 1973-10-15 Impact factor: 5.469

3. De-methylation of displacement loop of mitochondrial DNA is associated with increased mitochondrial copy number and nicotinamide adenine dinucleotide subunit 2 expression in colorectal cancer.

Authors: Jinhang Gao; Shilei Wen; Hongying Zhou; Shi Feng
Journal: Mol Med Rep Date: 2015-08-26 Impact factor: 2.952

Review 4. Mitochondrial DNA damage and repair in neurodegenerative disorders.

Authors: Jenq-Lin Yang; Lior Weissman; Vilhelm A Bohr; Mark P Mattson
Journal: DNA Repair (Amst) Date: 2008-05-07

5. Epigenome-wide association study for Parkinson's disease.

Authors: Kerry Moore; Amy Jayne McKnight; David Craig; Francis O'Neill
Journal: Neuromolecular Med Date: 2014-10-11 Impact factor: 3.843

6. Complete Genome Sequence of Sporisorium scitamineum and Biotrophic Interaction Transcriptome with Sugarcane.

Authors: Lucas M Taniguti; Patricia D C Schaker; Juliana Benevenuto; Leila P Peters; Giselle Carvalho; Alessandra Palhares; Maria C Quecine; Filipe R S Nunes; Maria C P Kmit; Alvan Wai; Georg Hausner; Karen S Aitken; Paul J Berkman; James A Fraser; Paula M Moolhuijzen; Luiz L Coutinho; Silvana Creste; Maria L C Vieira; João P Kitajima; Claudia B Monteiro-Vitorello
Journal: PLoS One Date: 2015-06-12 Impact factor: 3.240

7. Effects of Tet-mediated oxidation products of 5-methylcytosine on DNA transcription in vitro and in mammalian cells.

Authors: Changjun You; Debin Ji; Xiaoxia Dai; Yinsheng Wang
Journal: Sci Rep Date: 2014-11-14 Impact factor: 4.379

8. Platelet mitochondrial DNA methylation: a potential new marker of cardiovascular disease.

Authors: Andrea A Baccarelli; Hyang-Min Byun
Journal: Clin Epigenetics Date: 2015-04-16 Impact factor: 6.551

9. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options.

Authors: Bayani Uttara; Ajay V Singh; Paolo Zamboni; R T Mahajan
Journal: Curr Neuropharmacol Date: 2009-03 Impact factor: 7.363

10. Efficient and accurate whole genome assembly and methylome profiling of E. coli.

Authors: Jason G Powers; Victor J Weigman; Jenny Shu; John M Pufky; Donald Cox; Patrick Hurban
Journal: BMC Genomics Date: 2013-10-03 Impact factor: 3.969

11 in total

1. Hypermethylation of Mitochondrial Cytochrome b and Cytochrome c Oxidase II Genes with Decreased Mitochondrial DNA Copy Numbers in the APP/PS1 Transgenic Mouse Model of Alzheimer's Disease.

Authors: Yingying Xu; Ling Cheng; Jing Sun; Fan Li; Xiangtian Liu; Yan Wei; Min Han; Zhengyu Zhu; Jianzhong Bi; Chao Lai; Yun Wang
Journal: Neurochem Res Date: 2021-02-12 Impact factor: 3.996

Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies.

1. Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture.

2. Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells. In vivo and in vitro methylation.

3. De-methylation of displacement loop of mitochondrial DNA is associated with increased mitochondrial copy number and nicotinamide adenine dinucleotide subunit 2 expression in colorectal cancer.

Review 4. Mitochondrial DNA damage and repair in neurodegenerative disorders.

5. Epigenome-wide association study for Parkinson's disease.

6. Complete Genome Sequence of Sporisorium scitamineum and Biotrophic Interaction Transcriptome with Sugarcane.

7. Effects of Tet-mediated oxidation products of 5-methylcytosine on DNA transcription in vitro and in mammalian cells.

8. Platelet mitochondrial DNA methylation: a potential new marker of cardiovascular disease.

9. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options.

10. Efficient and accurate whole genome assembly and methylome profiling of E. coli.

1. Hypermethylation of Mitochondrial Cytochrome b and Cytochrome c Oxidase II Genes with Decreased Mitochondrial DNA Copy Numbers in the APP/PS1 Transgenic Mouse Model of Alzheimer's Disease.

Review 2. Mitochondrial-epigenetic crosstalk in environmental toxicology.

Review 3. Mitochondrial DNA Methylation and Human Diseases.

4. lncRNA Neat1 regulates neuronal dysfunction post-sepsis via stabilization of hemoglobin subunit beta.

5. Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue.

Review 6. Mitoepigenetics and Neurodegenerative Diseases.

7. Mitochondrial Dysfunction in Autism Spectrum Disorders.

8. Biological networks in Parkinson's disease: an insight into the epigenetic mechanisms associated with this disease.

Review 9. Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders.

10. Platelet mitochondrial DNA methylation predicts future cardiovascular outcome in adults with overweight and obesity.