Hydrothermal synthesis of Ag@MSiO2@Ag three core-shell nanoparticles and their sensitive and stable SERS properties.

An Ag@MSiO2@Ag three core-shell architecture was synthesized by a facial hydrothermal method. The features of the sample were characterized by SEM, TEM, and AFM images, EDS analyses and absorption spectra. This novel nanostructure exhibited excellent SERS properties due to the formation of hot spots around the inner and outer Ag NPs, which were identified by theoretical calculations. A detection limit of the analyte molecule was obtained as low as 10(-11) M by using this SERS nanostructure. Moreover, the homogeneity of SERS signals from the three core-shell nanostructure was checked by Raman mapping. Our studies show that the unique Ag@MSiO2@Ag three core-shell nanostructure has significant potential to realize a SERS substrate with both sensitivity and stability, which are important in SERS-based immunoassay.