Literature DB >> 26876228

Protonation state of F420H2 in the prodrug-activating deazaflavin dependent nitroreductase (Ddn) from Mycobacterium tuberculosis.

A Elaaf Mohamed1, F Hafna Ahmed, Sundaram Arulmozhiraja, Ching Y Lin, Matthew C Taylor, Elmars R Krausz, Colin J Jackson, Michelle L Coote.   

Abstract

The protonation state of the deazaflavin dependent nitroreductase (Ddn) enzyme bound cofactor F420 was investigated using UV-visible spectroscopy and computational simulations. The reduced cofactor F420H2 was determined to be present in its deprotonated state in the holoenzyme form. The mechanistic implications of these findings are discussed.

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Year:  2016        PMID： 26876228     DOI： 10.1039/c6mb00033a

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  8 in total

1.  The Redox Cofactor F420 Protects Mycobacteria from Diverse Antimicrobial Compounds and Mediates a Reductive Detoxification System.

Authors:  Thanavit Jirapanjawat; Blair Ney; Matthew C Taylor; Andrew C Warden; Shahana Afroze; Robyn J Russell; Brendon M Lee; Colin J Jackson; John G Oakeshott; Gunjan Pandey; Chris Greening
Journal:  Appl Environ Microbiol       Date:  2016-09-16       Impact factor: 4.792

2.  Rv2074 is a novel F420 H2 -dependent biliverdin reductase in Mycobacterium tuberculosis.

Authors:  F Hafna Ahmed; A Elaaf Mohamed; Paul D Carr; Brendon M Lee; Karmen Condic-Jurkic; Megan L O'Mara; Colin J Jackson
Journal:  Protein Sci       Date:  2016-07-17       Impact factor: 6.725

Review 3.  Physiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions.

Authors:  Chris Greening; F Hafna Ahmed; A Elaaf Mohamed; Brendon M Lee; Gunjan Pandey; Andrew C Warden; Colin Scott; John G Oakeshott; Matthew C Taylor; Colin J Jackson
Journal:  Microbiol Mol Biol Rev       Date:  2016-04-27       Impact factor: 11.056

4.  Cofactor F420: an expanded view of its distribution, biosynthesis and roles in bacteria and archaea.

Authors:  Rhys Grinter; Chris Greening
Journal:  FEMS Microbiol Rev       Date:  2021-09-08       Impact factor: 16.408

5.  Mycobacterial F420H2-Dependent Reductases Promiscuously Reduce Diverse Compounds through a Common Mechanism.

Authors:  Chris Greening; Thanavit Jirapanjawat; Shahana Afroze; Blair Ney; Colin Scott; Gunjan Pandey; Brendon M Lee; Robyn J Russell; Colin J Jackson; John G Oakeshott; Matthew C Taylor; Andrew C Warden
Journal:  Front Microbiol       Date:  2017-05-31       Impact factor: 5.640

6.  Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria.

Authors:  Rhys Grinter; Blair Ney; Rajini Brammananth; Christopher K Barlow; Paul R F Cordero; David L Gillett; Thierry Izoré; Max J Cryle; Liam K Harold; Gregory M Cook; George Taiaroa; Deborah A Williamson; Andrew C Warden; John G Oakeshott; Matthew C Taylor; Paul K Crellin; Colin J Jackson; Ralf B Schittenhelm; Ross L Coppel; Chris Greening
Journal:  mSystems       Date:  2020-05-19       Impact factor: 6.496

7.  The pursuit of mechanism of action: uncovering drug complexity in TB drug discovery.

Authors:  Tianao Yuan; Joshua M Werman; Nicole S Sampson
Journal:  RSC Chem Biol       Date:  2021-01-13

8.  Cofactor Tail Length Modulates Catalysis of Bacterial F420-Dependent Oxidoreductases.

Authors:  Blair Ney; Carlo R Carere; Richard Sparling; Thanavit Jirapanjawat; Matthew B Stott; Colin J Jackson; John G Oakeshott; Andrew C Warden; Chris Greening
Journal:  Front Microbiol       Date:  2017-09-27       Impact factor: 5.640
  8 in total

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