Sea-Won Lee1, Keon Wook Kang2,3, Hong-Gyun Wu1,4,3. 1. Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea. 2. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea. 3. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. 4. Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea.
Abstract
BACKGROUND: The purpose of this study was to prospectively evaluate the scintigraphic results on patients who undergo intensity-modulated radiotherapy (IMRT) to investigate the tolerance doses for the salivary glands. METHODS: Salivary scintigraphy was performed on 35 patients with head and neck cancer before the beginning of radiotherapy (RT), and then at 6 weeks and again at 3 months after the completion of RT. Xerostomia was recorded according to the Radiation Therapy and Oncology Group (RTOG) grade. Salivary function was evaluated by calculating the excretion rate changes (ΔF) for each salivary gland before and after RT. RESULTS: The parotid mean dose was significantly related to parotid ΔF and the submandibular gland mean dose to the submandibular gland ΔF. The parotid mean dose of 23 Gy was best correlated with the RTOG grades. The submandibular gland mean dose significantly related to ΔF ≤-50% and ≤-75% was 42 Gy. CONCLUSION: The parotid mean dose of 23 Gy and the submandibular gland mean dose of 42 Gy is feasible for salivary function preservation in the IMRT era.
BACKGROUND: The purpose of this study was to prospectively evaluate the scintigraphic results on patients who undergo intensity-modulated radiotherapy (IMRT) to investigate the tolerance doses for the salivary glands. METHODS: Salivary scintigraphy was performed on 35 patients with head and neck cancer before the beginning of radiotherapy (RT), and then at 6 weeks and again at 3 months after the completion of RT. Xerostomia was recorded according to the Radiation Therapy and Oncology Group (RTOG) grade. Salivary function was evaluated by calculating the excretion rate changes (ΔF) for each salivary gland before and after RT. RESULTS: The parotid mean dose was significantly related to parotid ΔF and the submandibular gland mean dose to the submandibular gland ΔF. The parotid mean dose of 23 Gy was best correlated with the RTOG grades. The submandibular gland mean dose significantly related to ΔF ≤-50% and ≤-75% was 42 Gy. CONCLUSION: The parotid mean dose of 23 Gy and the submandibular gland mean dose of 42 Gy is feasible for salivary function preservation in the IMRT era.
Authors: S B Lim; C J Tsai; Y Yu; P Greer; T Fuangrod; K Hwang; S Fontenla; F Coffman; N Lee; D M Lovelock Journal: Technol Cancer Res Treat Date: 2019-01-01
Authors: Seng Boh Lim; Nancy Lee; Kaveh Zakeri; Peter Greer; Todsaporn Fuangrod; Frederick Coffman; Laura Cerviño; D Michael Lovelock Journal: Technol Cancer Res Treat Date: 2021 Jan-Dec