Literature DB >> 26874237

Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response.

Mohamed H Shahin1, Julie A Johnson2.   

Abstract

Thiazide (TZD) diuretics are among the most commonly prescribed antihypertensives globally; however their chronic blood pressure (BP) lowering mechanism remains unclear. Herein we discuss the current evidence regarding specific mechanisms regulating the antihypertensive effects of TZDs, suggesting that TZDs act via multiple complex and interacting mechanisms, including natriuresis with short term use and direct vasodilatory effects chronically. Additionally, we review pharmacogenomics signals that have been associated with TZDs BP-response in several cohorts (i.e. NEDD4L, PRKCA, EDNRA-GNAS, and YEATS4) and discuss how these genes might be related to TZD BP-response mechanism. Understanding the association between these genes and TZD BP mechanism might facilitate the development of new drugs and therapeutic approaches based on a deeper understanding of the determinants of BP-response.
Copyright © 2016. Published by Elsevier Ltd.

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Year:  2016        PMID： 26874237      PMCID： PMC4915478          DOI： 10.1016/j.coph.2016.01.005

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  39 in total

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Authors:  Julio D Duarte; Rhonda M Cooper-DeHoff
Journal:  Expert Rev Cardiovasc Ther       Date:  2010-06

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Authors:  P Pickkers; R S Garcha; M Schachter; P Smits; A D Hughes
Journal:  Hypertension       Date:  1999-04       Impact factor: 10.190

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Journal:  Lancet       Date:  2005 Jan 15-21       Impact factor: 79.321

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Journal:  Am Heart J       Date:  1978-05       Impact factor: 4.749

5.  Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta.

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Journal:  Eur J Pharmacol       Date:  2000-11-10       Impact factor: 4.432

6.  Do diuretics have antihypertensive properties independent of natriuresis?

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Journal:  Clin Pharmacol Ther       Date:  1977-11       Impact factor: 6.875

7.  Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2.

Authors:  Peijun P Shi; Xiao R Cao; Eileen M Sweezer; Thomas S Kinney; Nathan R Williams; Russell F Husted; Ramesh Nair; Robert M Weiss; Roger A Williamson; Curt D Sigmund; Peter M Snyder; Olivier Staub; John B Stokes; Baoli Yang
Journal:  Am J Physiol Renal Physiol       Date:  2008-06-04

8.  Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney.

Authors:  Fei Ma; Fan Lin; Chen Chen; Jennifer Cheng; Darryl C Zeldin; Yan Wang; Dao Wen Wang
Journal:  Mol Pharmacol       Date:  2013-05-31       Impact factor: 4.436

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Authors:  P Pickkers; A D Hughes
Journal:  Br J Pharmacol       Date:  1995-02       Impact factor: 8.739

10.  Potassium channel opening properties of thiazide diuretics in isolated guinea pig resistance arteries.

Authors:  J A Calder; M Schachter; P S Sever
Journal:  J Cardiovasc Pharmacol       Date:  1994-07       Impact factor: 3.105
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  12 in total

1.  Lack of thiazide diuretic inhibition of agonist constriction of mouse mesenteric arterioles ex vivo.

Authors:  Robert M Rapoport; Amanda J LeBlanc; Jason E Beare; Manoocher Soleimani
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2018-11-23       Impact factor: 3.000

Review 2.  Should All Patients with Resistant Hypertension Receive Spironolactone?

Authors:  Ján Rosa; Tomáš Zelinka; Ondřej Petrák; Branislav Štrauch; Robert Holaj; Jiří Widimský
Journal:  Curr Hypertens Rep       Date:  2016-11       Impact factor: 5.369

Review 3.  Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide.

Authors:  Erika Salvi; Zhiying Wang; Federica Rizzi; Yan Gong; Caitrin W McDonough; Sandosh Padmanabhan; Timo P Hiltunen; Chiara Lanzani; Roberta Zaninello; Martina Chittani; Kent R Bailey; Antti-Pekka Sarin; Matteo Barcella; Olle Melander; Arlene B Chapman; Paolo Manunta; Kimmo K Kontula; Nicola Glorioso; Daniele Cusi; Anna F Dominiczak; Julie A Johnson; Cristina Barlassina; Eric Boerwinkle; Rhonda M Cooper-DeHoff; Stephen T Turner
Journal:  Hypertension       Date:  2016-10-31       Impact factor: 10.190

Review 4.  Hypertension: a new treatment for an old disease? Targeting the immune system.

Authors:  Gisele Facholi Bomfim; Stefany Bruno Assis Cau; Alexandre Santos Bruno; Aline Garcia Fedoce; Fernando S Carneiro
Journal:  Br J Pharmacol       Date:  2018-07-31       Impact factor: 8.739

5.  Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response.

Authors:  Mohamed H Shahin; Ana C Sá; Amy Webb; Yan Gong; Taimour Langaee; Caitrin W McDonough; Alberto Riva; Amber L Beitleshees; Arlene B Chapman; John G Gums; Stephen T Turner; Eric Boerwinkle; Steven E Scherer; Wolfgang Sadee; Rhonda M Cooper-DeHoff; Julie A Johnson
Journal:  Circ Cardiovasc Genet       Date:  2017-01

6.  Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics.

Authors:  Mohamed H Shahin; Yan Gong; Reginald F Frye; Daniel M Rotroff; Amber L Beitelshees; Rebecca A Baillie; Arlene B Chapman; John G Gums; Stephen T Turner; Eric Boerwinkle; Alison Motsinger-Reif; Oliver Fiehn; Rhonda M Cooper-DeHoff; Xianlin Han; Rima Kaddurah-Daouk; Julie A Johnson
Journal:  J Am Heart Assoc       Date:  2017-12-29       Impact factor: 5.501

7.  A Systems Analysis of the Relationships Between Anemia and Ischemic Stroke Rehabilitation Based on RNA-Seq Data.

Authors:  Yingying Wang; Xingxian Huang; Jianfeng Liu; Xuefei Zhao; Haibo Yu; Yunpeng Cai
Journal:  Front Genet       Date:  2019-05-24       Impact factor: 4.599

8.  A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration.

Authors:  Mohamed H Shahin; Yan Gong; Caitrin W McDonough; Daniel M Rotroff; Amber L Beitelshees; Timothy J Garrett; John G Gums; Alison Motsinger-Reif; Arlene B Chapman; Stephen T Turner; Eric Boerwinkle; Reginald F Frye; Oliver Fiehn; Rhonda M Cooper-DeHoff; Rima Kaddurah-Daouk; Julie A Johnson
Journal:  Hypertension       Date:  2016-07-05       Impact factor: 10.190

9.  Assessing the negative impact of phenyl alkanoic acid derivative, a frequently prescribed drug for the suppression of pain and inflammation, on the differentiation and proliferation of chondrocytes.

Authors:  Seyit Ali Gumustas; İbrahim Yilmaz; Mehmet Isyar; Duygu Yasar Sirin; Ahmet Guray Batmaz; Ali Akin Ugras; Kadir Oznam; Zafer Ciftci; Mahir Mahirogullari
Journal:  J Orthop Surg Res       Date:  2016-06-30       Impact factor: 2.359

10.  Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue.

Authors:  Numan Karaarslan; Ahmet Guray Batmaz; Ibrahim Yilmaz; Hanefi Ozbek; Tezcan Caliskan; Duygu Yasar Sirin; Necati Kaplan; Kadir Oznam; Ozkan Ates
Journal:  Exp Ther Med       Date:  2018-06-26       Impact factor: 2.447
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