Literature DB >> 26873248

Non-essential contribution of LRRC8A to volume regulation.

Lalida Sirianant1, Podchanart Wanitchakool1, Jiraporn Ousingsawat1, Roberta Benedetto1, Anna Zormpa1, Ines Cabrita1, Rainer Schreiber1, Karl Kunzelmann2.   

Abstract

Volume regulation is an essential property of any living cell and needs to be tightly controlled. While different types of K(+) channels have been found to participate in the regulation of cell volume, the newly identified volume-regulated anion channel (VRAC) LRRC8 has been claimed to be essential for volume regulation. In unbiased genome-wide small interfering RNA (siRNA) screens, two independent studies identified LRRC8A/Swell1 as an essential component of VRAC, thus being indispensable for cellular volume regulation. We reanalyzed the role of LRRC8A for VRAC and regulatory volume decrease (RVD) in several cell types and under various conditions. While the role of LRRC8A for VRAC and its contribution to RVD is confirmed, we find that it is not essential for swelling-activated anion currents or cellular volume regulation, or apoptotic cell shrinkage. The contribution of LRRC8A is variable and largely depending on the cell type.

Entities:  

Keywords:  AVD; LRRC8A; RVD, apoptotic volume decrease; VRAC; Volume regulation: regulatory volume decrease; Volume-activated anion channels

Mesh：

Substances：

Year:  2016        PMID： 26873248     DOI： 10.1007/s00424-016-1789-6

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  27 in total

Review 1.  The identification of a volume-regulated anion channel: an amazing Odyssey.

Authors:  S F Pedersen; T K Klausen; B Nilius
Journal:  Acta Physiol (Oxf)       Date:  2015-01-28       Impact factor: 6.311

2.  Anoctamin 6 differs from VRAC and VSOAC but is involved in apoptosis and supports volume regulation in the presence of Ca2+.

Authors:  C A Juul; S Grubb; K A Poulsen; T Kyed; N Hashem; I H Lambert; E H Larsen; E K Hoffmann
Journal:  Pflugers Arch       Date:  2014-01-14       Impact factor: 3.657

3.  Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.

Authors:  Felizia K Voss; Florian Ullrich; Jonas Münch; Katina Lazarow; Darius Lutter; Nancy Mah; Miguel A Andrade-Navarro; Jens P von Kries; Tobias Stauber; Thomas J Jentsch
Journal:  Science       Date:  2014-04-10       Impact factor: 47.728

4.  cAMP inhibition of murine intestinal Na/H exchange requires CFTR-mediated cell shrinkage of villus epithelium.

Authors:  Lara R Gawenis; Craig L Franklin; Janet E Simpson; Bradley A Palmer; Nancy M Walker; Tarra M Wiggins; Lane L Clarke
Journal:  Gastroenterology       Date:  2003-10       Impact factor: 22.682

5.  Silencing of human papillomavirus (HPV) E6/E7 oncogene expression affects both the contents and the amounts of extracellular microvesicles released from HPV-positive cancer cells.

Authors:  Anja Honegger; Jenny Leitz; Julia Bulkescher; Karin Hoppe-Seyler; Felix Hoppe-Seyler
Journal:  Int J Cancer       Date:  2013-04-30       Impact factor: 7.396

6.  SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel.

Authors:  Zhaozhu Qiu; Adrienne E Dubin; Jayanti Mathur; Buu Tu; Kritika Reddy; Loren J Miraglia; Jürgen Reinhardt; Anthony P Orth; Ardem Patapoutian
Journal:  Cell       Date:  2014-04-10       Impact factor: 41.582

7.  Inactivation of the murine cftr gene abolishes cAMP-mediated but not Ca(2+)-mediated secretagogue-induced volume decrease in small-intestinal crypts.

Authors:  M A Valverde; J A O'Brien; F V Sepúlveda; R Ratcliff; M J Evans; W H Colledge
Journal:  Pflugers Arch       Date:  1993-12       Impact factor: 3.657

8.  Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice.

Authors:  M A Valverde; J A O'Brien; F V Sepúlveda; R A Ratcliff; M J Evans; W H Colledge
Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-26       Impact factor: 11.205

9.  Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.

Authors:  Lalit Kumar; Janet Chou; Christina S K Yee; Arturo Borzutzky; Elisabeth H Vollmann; Ulrich H von Andrian; Shin-Young Park; Georg Hollander; John P Manis; P Luigi Poliani; Raif S Geha
Journal:  J Exp Med       Date:  2014-04-21       Impact factor: 14.307

Review 10.  Structure and function of TMEM16 proteins (anoctamins).

Authors:  Nicoletta Pedemonte; Luis J V Galietta
Journal:  Physiol Rev       Date:  2014-04       Impact factor: 37.312
View more
  19 in total

1.  Cl- channels in apoptosis.

Authors:  Podchanart Wanitchakool; Jiraporn Ousingsawat; Lalida Sirianant; Nanna MacAulay; Rainer Schreiber; Karl Kunzelmann
Journal:  Eur Biophys J       Date:  2016-06-07       Impact factor: 1.733

2.  Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid.

Authors:  Rainer Schreiber; Jiraporn Ousingsawat; Podchanart Wanitchakool; Lalida Sirianant; Roberta Benedetto; Karina Reiss; Karl Kunzelmann
Journal:  J Physiol       Date:  2017-12-18       Impact factor: 5.182

3.  Calcium is not required for triggering volume restoration in hypotonically challenged A549 epithelial cells.

Authors:  Olga Ponomarchuk; Francis Boudreault; Sergei N Orlov; Ryszard Grygorczyk
Journal:  Pflugers Arch       Date:  2016-10-31       Impact factor: 3.657

4.  CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6).

Authors:  Filipa Simões; Jiraporn Ousingsawat; Podchanart Wanitchakool; Ana Fonseca; Inês Cabrita; Roberta Benedetto; Rainer Schreiber; Karl Kunzelmann
Journal:  Pflugers Arch       Date:  2017-09-05       Impact factor: 3.657

5.  Specific and essential but not sufficient roles of LRRC8A in the activity of volume-sensitive outwardly rectifying anion channel (VSOR).

Authors:  Toshiaki Okada; Md Rafiqul Islam; Nargiza A Tsiferova; Yasunobu Okada; Ravshan Z Sabirov
Journal:  Channels (Austin)       Date:  2016-10-20       Impact factor: 2.581

6.  LRRC8A channels support TNFα-induced superoxide production by Nox1 which is required for receptor endocytosis.

Authors:  Hyehun Choi; Nicholas Ettinger; Jeffrey Rohrbough; Anna Dikalova; Hong N Nguyen; Fred S Lamb
Journal:  Free Radic Biol Med       Date:  2016-11-09       Impact factor: 7.376

7.  Plasma membrane-localized TMEM16 proteins are indispensable for expression of CFTR.

Authors:  Roberta Benedetto; Jiraporn Ousingsawat; Inês Cabrita; Madalena Pinto; Joana R Lérias; Podchanart Wanitchakool; Rainer Schreiber; Karl Kunzelmann
Journal:  J Mol Med (Berl)       Date:  2019-03-26       Impact factor: 4.599

8.  The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH.

Authors:  Runping Wang; Yongjun Lu; Susheel Gunasekar; Yanhui Zhang; Christopher J Benson; Mark W Chapleau; Rajan Sah; François M Abboud
Journal:  JCI Insight       Date:  2017-03-09

9.  Relationship between TMEM16A/anoctamin 1 and LRRC8A.

Authors:  Roberta Benedetto; Lalida Sirianant; Ines Pankonien; Podchanart Wanitchakool; Jiraporn Ousingsawat; Ines Cabrita; Rainer Schreiber; Margarida Amaral; Karl Kunzelmann
Journal:  Pflugers Arch       Date:  2016-08-12       Impact factor: 3.657

10.  Leucine-rich repeat containing protein LRRC8A is essential for swelling-activated Cl- currents and embryonic development in zebrafish.

Authors:  Toshiki Yamada; Robert Wondergem; Rebecca Morrison; Viravuth P Yin; Kevin Strange
Journal:  Physiol Rep       Date:  2016-10
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.