| Literature DB >> 26872860 |
Fabio D'Amico1, Evangelia Skarmoutsou2, Mariagrazia Granata3, Chiara Trovato4, Giulio Antonino Rossi5, Maria Clorinda Mazzarino6.
Abstract
S100A7 (psoriasin), an EF-hand type calcium binding protein localized in epithelial cells, regulates cell proliferation and differentiation. An S100A7 overexpression may occur in response to inflammatory stimuli, such in psoriasis, a chronic inflammatory autoimmune-mediated skin disease. Increasing evidence suggests that S100A7 plays critical roles in amplifying the inflammatory process in psoriatic skin, perpetuating the disease phenotype. This review will discuss the interactions between S100A7 and cytokines in psoriatic skin. Furthermore, we will focus our discussion on regulation and functions of S100A7 in psoriasis. Finally, we will discuss the possible use of S100A7 as therapeutic target in psoriasis. Copyright ÂEntities:
Keywords: Keratinocyte; Psoriasin; Psoriasis; S100A7
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Year: 2016 PMID： 26872860 DOI： 10.1016/j.cytogfr.2016.01.002
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638