| Literature DB >> 26871708 |
María J Soto-Méndez, Concepción M Aguilera, María D Mesa, Laura Campaña-Martín, Victoria Martín-Laguna, Noel W Solomons, Klaus Schümann, Ángel Gil.
Abstract
Entities:
Year: 2016 PMID: 26871708 PMCID: PMC4752482 DOI: 10.1371/journal.pone.0149740
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Comparisons of oxidation and anti-oxidation biomarkers concentrations and activities by setting.
| Biomarker | Center A | Center B | Center C | ||||
|---|---|---|---|---|---|---|---|
| (semi-urban [n = 18]) Median [95% CI] | (marginal-urban [n = 23]) Median [95% CI] | (rural [n = 32]) Median [95% CI] | p-value | ||||
| 8-OHdG (ng/mL) | 4.33a [3.61–5.60] | ↓ | ↑ | 5.10ab [4.84–11.41] | - | 0.044 | |
| 8-OHdG (ng/mg creatinine) | 13.90a [11.95–15.87] | ↓ | ↑ | ↑ | 0.004 | ||
| F2-Iso (ng/mL) | 0.88a [0.80–1.14] | ↓ | ↑ | 1.72c [1.58–2.55] | - | <0.001 | |
| F2-Iso (ng/mg creatinine) | 2.72a [2.63–3.43] | ↓ | ↑ | 5.85c [5.28–8.96] | - | <0.001 | |
| CAT (nmol/seg/ g Hb) | 5.97a [5.38–6.37] | 7.68b [7.20–8.35] | 6.75a [6.19–6.99] | <0.001 | |||
| SOD (U/g Hb) | 0.60a [0.52–0.76] | 1.57b [1.46–1.82] | 1.95b [1.77–2.10] | <0.001 | |||
| GSR (umol/min/g Hb) | 2.21a [2.18–2.73] | 3.37b [3.08–3.48] | 2.74a [2.50–2.87] | <0.001 | |||
| GPX (μU/g Hb) | 5.68ab [5.33–6.37] | 4.91a [4.37–6.02] | 6.57b [5.83–7.38] | 0.020 | |||
| Retinol (mg/dL) | 23.34a [21.42–24.68] | ↑ | ↓ | 23.98a [21.53–24.85] | ↑ | <0.001 | |
| Tocopherols (mg/L) | 4.30a [4.06–4.78] | ↑ | ↓ | 4.21a [3.89–4.58] | ↑ | <0.001 | |
| β-carotene (mg/L) | 1.65a [1.38–1.92] | ↑ | ↓ | ↓ | <0.001 | ||
| CO-Q9 (mg/L) | 0.044a [0.043–0.047] | ↑ | ↓ | 0.043ab [0.043–0.046] | - | 0.020 | |
| CO-Q10 (mg/L) | 0.20ab [0.19–0.22] | - | ↓ | 0.21a [0.21–0.23] | ↑ | 0.004 | |
*Across the rows, values not sharing the same superscript letter are statistically different by the Kruskal-Wallis test. The upward arrow represents the highest value(s) in the cross-row set, whereas the downward arrow represents the lowest value(s).
The hyphen represents the intermediary value in a set. Such analysis was not made for antioxidant enzymes, as they do not have a reference value. The bold font indicates the least favorable median value. Anti-oxidant enzymes have no a priori assignment for favorability.