| Literature DB >> 26871623 |
Abstract
Mouse embryonic stem cells (mESCs) are capable of unlimited proliferation without losing pluripotency. Scognamiglio et al. now reveal that Myc depletion shifts mESCs into a dormant state reminiscent of embryonic diapause in which pluripotency remains fully preserved, thus decoupling pluripotency from proliferative programs.Entities:
Mesh：
Substances：
Year: 2016 PMID： 26871623 DOI： 10.1016/j.cell.2016.01.050
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582