Literature DB >> 2687156

Human-mouse hybrids carrying fragments of single human chromosomes selected by tumor growth.

D J Porteous1, M M Wilkinson, J M Fletcher, V van Heyningen.   

Abstract

Fusion of human EJ bladder carcinoma cells to mouse C127 cells, with direct selection for tumor growth, gave rise to hybrid cells in which the human chromosome complement had been reduced dramatically, while selectively retaining the activated HRAS1 at chromosome band 11p15. A single-component hybrid retaining only part of human chromosome 11 is described in detail. Our results suggest a novel and general approach for investigating the chromosomal basis of neoplastic change and for subchromosomal mapping of and enrichment cloning for the human genome.

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Year:  1989        PMID： 2687156     DOI： 10.1016/0888-7543(89)90108-0

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  3 in total

1.  The QM gene is X-linked and therefore not involved in suppression of tumorigenesis in Wilms' tumor.

Authors:  A M van den Ouweland; M Verdijk; M M Mannens; B A van Oost
Journal:  Hum Genet       Date:  1992 Sep-Oct       Impact factor: 4.132

2.  Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene.

Authors:  J T Pang; S E Lloyd; C Wooding; B Farren; B Pottinger; B Harding; S E Leigh; M A Pook; F J Benham; G T Gillett; R T Taggart; R V Thakker
Journal:  Hum Genet       Date:  1996-06       Impact factor: 4.132

3.  EagI and NotI linking clones from human chromosomes 11 and Xp.

Authors:  M A Pook; R Thakrar; B Pottinger; B Harding; D Porteous; V van Heyningen; J Cowell; C Jones; S Povey; K E Davies; R V Thakker
Journal:  Hum Genet       Date:  1996-06       Impact factor: 4.132
  3 in total

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