Long-term outcomes of different bortezomib-based regimens in Chinese myeloma patients.

Bortezomib has significantly increased the response rates in multiple myeloma (MM), but optimal bortezomib-based regimens for initial MM therapy have not yet been defined. We retrospectively compared the outcomes of 128 patients newly diagnosed with symptomatic MM who received either bortezomib combined with dexamethasone (PD) or three-drug combinations of PD with liposomal doxorubicin (PAD) or thalidomide (PTD). The overall response rate (ORR), very good partial response (VGPR) rate, and complete remission CR/near-complete remission (nCR) results were better for the PAD and PTD regimens than for the PD group. Three-year overall survival (OS) was 80.1%, 72.5%, and 61.8% with PAD, PTD, and PD regimens, respectively. The 3-year OS rate of PAD and PTD was significantly higher than that of PD (80.1% vs 61.8%, P=0.024; 72.5% vs 61.8%, P=0.035), but the difference was not statistically significant between PAD and PTD (80.1% vs 72.5%, P=0.843). Similarly, the PAD and PTD regimens resulted in significantly superior 3-year progression-free survival (PFS) rates. The patients in the PTD arm were more frequently observed with grade 1-3 peripheral neuropathy (PN), compared to those in the PAD and PD groups, especially grade 2-3 PN. PN developed less frequently without sacrificing the efficacy when bortezomib was administered subcutaneously rather than intravenously. Our experience suggests that the three-drug combinations PAD and PTD produce a better outcome than PD, especially with respect to PAD, with fewer adverse events.

Introduction

Multiple myeloma (MM) is a fatal plasma cell malignancy that mainly affects older individuals.1 Before the advent of novel therapies, conventional chemotherapy resulted in a complete remission (CR) rate of 5%–8% and median survival of about 3–5 years in MM patients.2 The outcome of MM has significantly improved due to the advances in treatment options. Bortezomib, which is a reversible proteasome inhibitor, has been shown to have a significant antitumor effect through various kinds of mechanisms. Multiple randomized controlled clinical trials confirm that the introduction of bortezomib in frontline regimens has increased the response rates and depth of responses, with even better survival time than using conventional chemotherapy regimens, such as melphalan and prednisone (MP) or vincristine, doxorubicin, and dexamethasone (VAD).3–5 Currently, combination chemotherapy based on bortezomib contains two or three drugs, but the differences between various kinds of regimens in terms of the effective rates and long-term outcomes have not been fully defined yet because there are few studies referring to these. Especially, the data on this topic from the People’s Republic of China are not sufficient. Since 2006, a fraction of patients newly diagnosed with MM were treated with different chemotherapy regimens based on bortezomib at Sun Yat-Sen University Cancer Center. In this study, we report the results of our retrospective analysis, the aim of which was to compare the effective rates and therapeutic outcomes of different combination therapies based on bortezomib for MM.

Materials and methods

Patients

From June 2006 to January 2014, a total of 128 consecutive patients newly diagnosed with MM received combination therapies based on bortezomib as the firstline chemotherapy for at least two cycles at the SunYat-Sen University Cancer Center. These patients were identified through the hospital discharge registry system and electronic medical records. The inclusion criteria of this retrospective clinical study were as follows: 1) newly diagnosed with symptomatic MM based on the diagnostic criteria of the World Health Organization; 2) had measurable monoclonal protein (M protein) in blood or urine; 3) previously untreated patients; 4) no previous or concomitant tumor; and 5) complete clinical information and long-term follow-up data available. All patients were staged according to the International Staging System (ISS) and Durie–Salmon (DS) staging. The Institutional Review Board of Sun Yat-Sen University Cancer Center approved this study, and all patients provided written informed consent forms in compliance with institutional guidelines. The study was performed in accordance with the guidelines of the Declaration of Helsinki.

Treatment

Bortezomib-based combination chemotherapy was given to patients, repeated every 3 weeks or 4 weeks as follows: 1) PD (bortezomib and dexamethasone); 2) PAD (bortezomib, dexamethasone, and liposomal doxorubicin); and 3) PTD (bortezomib, dexamethasone, and thalidomide). Among the treatment protocols, bortezomib (1.3 mg/m2) and dexamethasone (40 mg/d) were administered intravenously on Days 1, 4, 8, and 11, while liposomal doxorubicin (40 mg/m2) was administered intravenously on Day 1, and thalidomide (100 mg) was given orally each day, repeated every 3 weeks. After 2012, the protocol was amended to reduce the incidence of peripheral neuropathy. The administration methods for bortezomib were modified to subcutaneous (SC) injection (1.3 mg/m2) on Days 1, 8, 15, and 22, repeated every 4 weeks. Similarly, dexamethasone (40 mg/d) was given intravenously on the same day of the week.

Sixty-four patients underwent autologous hematopoietic stem cell transplantation (AHSCT) after induction therapy, including 22 cases who received PAD induction therapy, 27 cases who received PTD, and 15 cases who received PD. Patients with age ≥65 years or organ dysfunction were excluded from receiving AHSCT. After induction therapy or AHSCT, thalidomide (100 mg/d) was given orally to patients as maintenance treatment until disease progression or until they could not endure adverse drug reactions. Aspirin was routinely used to prevent thrombosis in patients who received PTD induction therapy or thalidomide for maintenance treatment. Granulocyte colony-stimulating factor (G-CSF) (5 µg/kg/d, SC injection) was administered to patients whose peripheral white blood cell counts were <2.0×109/L; G-CSF was administered until neutrophil counts recovered. Chemotherapy was administered only if the absolute neutrophil count was >1.5×109/L and the platelet count was >75×109/L before each cycle.

Response and toxicity criteria

The treatment response was assessed after every cycle during induction therapy and at 3 months and 6 months after AHSCT, in accordance with the International Melanoma Working Group response criteria. CR was defined as negative serum/urine immunofixation and normal bone marrow morphology. Very good partial response (VGPR) required >90% decrease of serum monoclonal proteins (M protein) and light chain in urine <100 mg/24 hours. During the maintenance treatment period, patients were followed up and assessed by their oncologist in the outpatient department every 2 months. All adverse effects were evaluated at each visit and graded based on the National Cancer Institute Common Terminology Criteria of Adverse Events v3.0.

Statistical analysis

Overall survival (OS) was calculated from the time of diagnosis until death from any cause or until the time of the last follow-up visit for the surviving patients. Progression-free survival (PFS) was defined as the interval from the initiation of chemotherapy to the time of the first documented disease progression or relapse or the interval from chemotherapy initiation to the last follow-up visit. The chi-square test was used to calculate statistical group comparisons of categorical variables. Survival analysis was performed using the Kaplan–Meier method, and comparisons were calculated using the log-rank test. Multivariate analysis was used to estimate the prognostic impact of different variables in terms of OS and PFS using the Cox regression model. The variables that were included in a multivariate analysis were statistically significant by univariate analysis. P<0.05 was considered statistically significant, and all P-values correspond to two-sided significance tests. Statistical analyses were performed using SPSS 17.0 software.

Results

Characteristics of patients

The comparative patient baseline characteristics for the PAD, PTD, and PD groups are summarized in Table 1. The median age at diagnosis was 60 years (range: 31–83 years) for the PAD group, 63 years (range: 29–79 years) for the PTD group, and 61 years (range: 38–81 years) for the PD group. According to DS staging, 100 (78.1%) patients were in stage III, while 96 (75%) patients were in stages II and III according to ISS staging. Among the total of 128 patients, 70 received bortezomib by SC administration and 58 by intravenous (IV) administration. As shown in Table 1, there were no significant differences in the rates of these characteristics between the three treatment groups.

Table 1

Baseline characteristics of patients

Characteristic	Total (n=128)	PAD (n=40)	PTD (n=52)	PD (n=36)
	N (%)	N (%)	N (%)	N (%)
Age, years
<65	82 (64.1)	25 (62.5)	34 (65.4)	23 (63.9)
≥65	46 (35.9)	15 (37.5)	18 (34.6)	13 (36.1)
Sex, male	84 (65.6)	28 (70.0)	33 (63.5)	23 (63.9)
ECOG PS
0–1	110 (85.9)	33 (82.5)	47 (90.4)	30 (83.3)
≥2	18 (14.1)	7 (17.5)	5 (9.6)	6 (16.7)
Durie–Salmon stage
1A	7 (5.5)	2 (5.0)	3 (5.8)	2 (5.6)
2A	21 (16.4)	5 (12.5)	9 (17.3)	7 (19.4)
3A	67 (52.3)	21 (52.5)	28 (53.8)	18 (50.0)
3B	33 (25.8)	12 (30.0)	12 (23.1)	9 (25.0)
ISS stage
I	32 (25.0)	14 (35.0)	11 (21.2)	7 (19.4)
II	50 (39.1)	9 (22.5)	23 (44.2)	18 (50.0)
III	46 (35.9)	17 (42.5)	18 (34.6)	11 (30.6)
Type of myeloma
IgA	30 (23.4)	8 (20.0)	14 (26.9)	8 (22.2)
IgG	65 (50.8)	26 (65.0)	23 (44.3)	16 (44.4)
IgD	4 (3.1)	1 (2.5)	1 (1.9)	2 (5.6)
Light chain	29 (22.7)	5 (12.5)	14 (26.9)	10 (27.8)
Serum LDH
≤ULN	107 (83.6)	32 (80.0)	43 (82.7)	32 (88.9)
>ULN	21 (16.4)	8 (20.0)	9 (17.3)	4 (11.1)
Genetic abnormalities
Yesa	71 (55.5)	24 (60.0)	29 (55.8)	18 (50.0)
No	57 (44.5)	16 (40.0)	23 (44.2)	18 (50.0)
Administration methods
Subcutaneous	70 (54.7)	23 (57.5)	34 (65.4)	13 (36.1)
Intravenous	58 (45.3)	17 (42.5)	18 (34.6)	23 (63.9)

Note:

Patients with abnormalities of 13q14, 1q21, 14q32, and 17p13.

Abbreviations: ECOG PS, Eastern Cooperative Oncology Group performance status; Ig, immunoglobulin; ISS, International Staging System; LDH, lactate dehydrogenase; PAD, PD with liposomal doxorubicin; PD, bortezomib combined with dexamethasone; PTD, PD with thalidomide; ULN, upper limit of normal.

Response

Totally, 164 cycles (median of four cycles) for the PAD group, 248 cycles (median of four cycles) for PTD group, and 156 cycles (median of four cycles) for PD group were performed. Table 2 summarizes the response rates for every treatment group. Postinduction overall response rate (ORR; ≥ partial response [PR]) in all the 128 eligible patients was 81.3%, including 28.1% VGPR and 32.1% CR/near-complete remission (nCR) rates. The ORR rates for the PAD or PTD group were significantly higher than those in the PD group (87.5% and 86.5%, vs 66.7%, respectively; P=0.030 and 0.026). The response rate in terms of VGPR plus CR/nCR rates in all the patients was 60.2%. VGPR rates in PAD and PTD groups were significantly higher than that in the PD group (35.0% and 32.7%, vs 13.9%, respectively; P=0.034 and 0.045). Similarly, CR/nCR rates in PAD and PTD arms were superior to that in PD (40.0% and 36.5%, vs 16.7%, respectively; P=0.025 and 0.042). Of the whole group of 128 patients, the overall CR/nCR rate and VGPR rates were 43.0% and 71.1% after AHSCT. Posttransplantation, CR/nCR and at least VGPR rates remained significantly higher in both PAD and PTD groups than in the PD group in transplant-eligible patients.

Table 2

Postinduction overall response rates of regimens

	ORR		PR		VGPR		CR/nCR
	N (%)	P-valuea	N (%)	P-value	N (%)	P-valueb	N (%)	P-valuec
PAD	35 (87.5)	0.030	5 (12.5)	0.016	14 (35.0)	0.034	16 (40.0)	0.025
PTD	45 (86.5)	0.026	9 (17.3)	0.045	17 (32.7)	0.045	19 (36.5)	0.042
PD	24 (66.7)		13 (36.1)		5 (13.9)		6 (16.7)

Notes:

Patients who received PAD or PTD demonstrated significantly higher ORR compared to those on PD (87.5% and 86.5% vs 66.7%, respectively; P=0.030 and 0.026 respectively).

Response rates defined as VGPR were significantly higher for PAD and PTD than for PD (35.0% and 32.7%, vs 13.9%, respectively; P=0.034 and 0.045 respectively).

Rates of patients showing CR/nCR were higher in PAD and PTD than in PD (40.0% and 36.5%, vs 16.7%, respectively; P=0.025 and 0.042 respectively).

Abbreviations: CR/nCR, complete remission/near-complete remission; ORR, overall response rate; PAD, PD with liposomal doxorubicin; PD, bortezomib combined with dexamethasone; PR, partial response; PTD, PD with thalidomide; VGPR, very good partial response.

Treatment outcomes and prognosis

The median follow-up time for the 128 patients from the time of diagnosis was 24 months (4.0–66.0 months). The median PFS and OS for all the patients were 38 months (95% confidence interval: 31.9–44.1 months) (Figure 1A) and not reached at 66 months (Figure 1B), respectively. The rates of 3-year PFS were 55.6%, 64.6%, and 32.9%, respectively, for the PAD, PTD, and PD regimens. The 3-year PFS rate for PAD and PTD was significantly higher than that for PD (55.6% and 64.6% vs 32.9%, respectively; P=0.020 and 0.024, respectively; Figure 2A). But, no significant difference was found between PAD and PTD groups. The rates of 3-year OS were 80.1%, 72.5%, and 61.8%, respectively, with PAD, PTD, and PD regimens. The 3-year OS rates of PAD and PTD were significantly higher than that of PD (P=0.024 and 0.035, respectively), but the difference was not statistically significant between PAD and PTD (P=0.843) (Figure 2B). No significant survival differences were found between the patients who received bortezomib by SC and those receiving it by IV (Figure 3). Upon further analysis, there were no significant survival differences observed according to the administration methods for bortezomib in every subgroup.

Figure 1

The survival data for all patients.

Notes: (A) Progression-free survival. (B) Overall survival.

Figure 2

Survival curves for patients with multiple myeloma.

Notes: (A) The 3-year PFS rates for PAD, PTD, and PD groups were 55.6%, 64.6%, and 32.9%, respectively; (B) 3-year OS rates for PAD, PTD, and PD groups were 89%, 72.5%, and 61.8%, respectively.

Abbreviations: OS, overall survival; PAD, PD with liposomal doxorubicin; PD, bortezomib combined with dexamethasone; PTD, PD with thalidomide; PFS, progression-free survival.

Figure 3

Survival outcomes of patients based on the methods of administration of bortezomib.

Notes: (A) PFS of patients according to the administration methods of bortezomib (SC vs IV). (B) OS of patients according to the administration methods for bortezomib (SC vs IV).

Abbreviations: IV, intravenous; OS, overall survival; PFS, progression-free survival; SC, subcutaneous.

The results of the multivariate analyses of clinical variables considered to be predictors of PFS and OS are shown in Table 3. Multivariate analysis revealed that a higher DS stage, elevated lactate dehydrogenase (LDH) level, induction therapy regimens, and certain cytogenetic abnormalities significantly affected patients’ PFS and OS, whereas age, Eastern Cooperative Oncology Group performance status (ECOG PS), and ISS stage had no effect on PFS and OS.

Table 3

Multivariate analysis of risk factors for PFS and OS

Risk factor	PFS		P-value	OS		P-value
	HR	95% CI		HR	95% CI
Age ≥65 years	1.287	0.508–3.258	0.594	2.531	0.483–13.254	0.272
ECOG PS ≥2	0.878	0.422–1.827	0.727	1.731	0.632–4.743	0.286
Durie–Salmon stage	2.026	1.366–3.210	0.001	3.528	1.471–8.458	0.005
ISS stage	1.104	0.625–1.949	0.733	1.522	0.576–4.023	0.397
LDH>ULN	2.830	1.279–5.322	0.008	6.238	2.193–17.750	0.001
Regimensa	0.580	0.426–0.874	0.007	0.422	0.236–0.754	0.004
FISHb	1.411	0.736–2.705	0.299	3.778	1.327–10.756	0.013

Notes:

Three-drug combinations compared with PD.

Patients with abnormalities of 13q14, 1q21, 14q32, and 17p13 compared with those showing no FISH abnormalities.

Abbreviations: CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group performance status; FISH, interphase fluorescence in situ hybridization; HR, hazard ratio; ISS, International Staging System; LDH, lactate dehydrogenase; OS, overall survival; PFS, progression-free survival; ULN, upper limit of normal; PD, bortezomib combined with dexamethasone.

Toxicity

In every treatment group, no patient had to discontinue treatment for severe adverse events and no treatment-related deaths occurred. The main hematological toxicities (Grade 3/4) were thrombocytopenia (16.4%), neutropenia (14.8%), and anemia (7.9%). Among the patients in each subgroup, no significant difference was found in terms of hematological toxicities (Grade 3/4). The most frequently observed nonhematological toxicities (all grades) included peripheral neuropathy (PN) (48.4%), infection (25.8%), fatigue (25.0%), etc (Table 4). The occurrence rates of constipation and herpes zoster in the PTD arm were significantly higher than in the PAD and PD groups. In all the patients enrolled, no one was observed with grade 4 PN. The patients in the PTD arm were more frequently observed with grade 1–3 PN compared to those in the PAD and PD groups. The incidence of PN (grades 2–3) in the PTD group was significantly higher compared to that in the PAD and PD arms. For all patients, the incidence of grades 2–3 PN was significantly higher in the IV administration group than in the SC administration group (Table 5). Similarly, the incidence of grades 2–3 PN was significantly different according to the administration methods for bortezomib in the PAD and PTD groups (Table 5). In the PD group, the incidence of grades 2–3 PN after IV administration was higher, although the difference was not statistically significant relative to the SC administration group.

Table 4

Treatment-related adverse events

Adverse events	Total, n (%)	PAD, n (%)	PTD, n (%)	PD, n (%)
	(n=128)	(n=40)	(n=52)	(n=36)
Hematologic events (Grade 3/4)
Neutropenia	19 (14.8)	7 (17.5)	8 (15.4)	4 (11.1)
Thrombocytopenia	21 (16.4)	8 (20.0)	8 (15.4)	5 (13.9)
Anemia	13 (7.9)	5 (12.5)	6 (11.5)	2 (5.6)
Nonhematologic events (all grades)
Fatigue	32 (25.0)	12 (30.0)	13 (25.0)	7 (19.4)
Infection	33 (25.8)	13 (32.5)	13 (25.0)	7 (19.4)
Constipationa	28 (21.9)	5 (12.5)	21 (40.4)	2 (5.6)
Diarrhea	16 (12.5)	5 (12.5)	6 (11.5)	5 (13.9)
Pleural effusion and ascites	7 (5.5)	2 (5.0)	3 (5.8)	2 (5.6)
Herpes zosterb	20 (15.6)	3 (7.5)	15 (28.8)	2 (5.6)
Deep vein thrombosis	1 (0.8)	0 (0.0)	1 (1.9)	0 (0.0)
Peripheral neuropathyc	62 (48.4)	15 (37.5)	34 (65.3)	13 (36.1)
Grade 1	40 (31.3)	11 (27.5)	19 (36.5)	10 (27.8)
Grade 2/3d	22 (17.1)	4 (10.0)	15 (28.8)	3 (8.3)

Notes:

Incidence of constipation for the PTD arm was significantly higher than for the PAD and PD groups (P=0.003 and <0.001, respectively).

Incidence of herpes zoster for the PTD arm was significantly higher than for the PAD and PD groups (P=0.011 and 0.007, respectively).

Peripheral neuropathy of all grades was more frequently reported in patients in the PTD group compared to those in the other groups, which was obviously higher than that of the PAD and PD groups (P=0.008 and 0.007, respectively).

Incidence of grades 2–3 peripheral neuropathy for the PTD arm was significantly higher than in the PAD and PD groups (P=0.027 and 0.019, respectively). There was no significant difference in other treatment-related adverse events among groups.

Table 5

Peripheral neuropathy in patients according to the administration method of bortezomib

	Subcutaneous	Intravenous	P-value	Subcutaneous	Intravenous	P-value
	Grade 1, n (%)	Grade 1, n (%)		Grade 2/3, n (%)	Grade 2/3, n (%)
Total	21 (30.0)	19 (32.8)	0.737	6 (8.6)	16 (27.6)	0.005
PAD	6 (26.1)	5 (29.4)	0.816	0 (0.0)	4 (23.5)	0.014
PTD	12 (35.3)	7 (38.9)	0.798	6 (17.6)	9 (50.0)	0.014
PD	3 (23.1)	7 (30.4)	0.636	0 (0.0)	3 (13.0)	0.174

Abbreviations: PAD, PD with liposomal doxorubicin; PD, bortezomib combined with dexamethasone; PTD, PD with thalidomide.

Discussion

MM still remains an incurable disease and nearly all patients eventually relapse and succumb to MM. To get a deeper response for longer duration is necessary for disease control, regardless of whether the patients are newly diagnosed ones or relapse/refractory patients.6–11 With the advent of novel proteasome inhibitors and immunomodulatory drugs, most patients can show higher response rate and improved PFS. Over the past few years, a number of prospective randomized clinical trials have demonstrated that the efficacies of bortezomib- and lenalidomide-based regimens are significantly superior to that of the traditional methods.3,12 However, few clinical trials have compared different regimens based on bortezomib to elucidate which is the most suitable one for the initial treatment of MM, with the aim of improving the long-term survival and quality of life of the patient.13,14 The objective of our study was to investigate the response rates, treatment outcomes, and toxicity profiles of different bortezomib-based regimens in Chinese myeloma patients. In this study, we found that the response rates for the PAD and PTD regimens were higher than those for PD, which could translate into improved survival.

In our study, the ORR for patients who were treated with the PD regimen was 66.7%, including 16.7% with CR/nCR and 13.9% with VGPR, which is consistent with the study conducted by He et al,15 also from the People’s Republic of China. Actually, many studies showed that the ORRs were in the range of 60%–85% with the PD regimen, including at least 30%–40% VGPR and ~20% CR/nCR.12,13,16,17 The IFM 2005-01 study,12 a Phase III clinical trial showed that the ORR, CR/nCR, and at least VGPR for the PD regimen were 78.5%, 14.8%, and 37.7%, respectively, in newly diagnosed patients regardless of adverse cytogenetic abnormalities or disease stage.12

The PD regimen after combining with another drug, an immunomodulatory agent such as thalidomide or a conventional cytotoxic drug such as adriamycin, can yield ORR of 90%, including at least 60%–70% VGPR and 40%–50% CR/nCR.18–20 At Sun Yat-Sen University Cancer Center, are used to replace adriamycin with liposomal doxorubicin because of the lower cardiotoxicity. In our analysis, patients were treated with a median of four cycles, and ~34.4% cases only received two or three cycles; the PAD regimen had similar effect as the PTD regimen. In terms of ORR, VGPR, and CR/nCR rates, PAD and PTD had advantage over PD. We found that similar results were obtained by another team from the People’s Republic of China.15 However, in a randomized trial,21 the Intergroupe Francophone du Myélome (IFM) research group reported that the regimen bortezomib and thalidomide plus dexamethasone (VTD), including reduced doses of bortezomib and thalidomide, yields higher VGPR rates after induction therapy, as well as CR plus VGPR rates after AHSCT, compared with VD (bortezomib–dexamethasone). In our study, the rates of 3-year OS in the PAD and PTD groups were significantly higher than those in the PD group (P=0.024 and 0.035, respectively). Interestingly, a recently published study22 showed that PTD did not appear to offer an advantage over VD in transplantation-ineligible patients with myeloma treated in US community practice. Nevertheless, half the number of patients in our study received AHSCT, which may be the main reason for the difference in the research results. Certainly, the results in our study should be interpreted within its limitations because it is a retrospective study. Further prospective research should be conducted on patients of larger sample sizes.

Multivariate analysis also indicated that a higher DS stage, elevated LDH level, induction therapy regimens, and certain cytogenetic abnormalities were independent prognostic factors for PFS and OS, which is in acccordance with those seen in other studies.23 However, ISS stage seems to be less helpful for predicting survival in our study; the results indicate that ISS had limitations when applied on MM patients in the People’s Republic of China. Our study and the study conducted by He et al15 from the People’s Republic of China achieved consistent results in this respect. Previous studies confirmed that LDH is an adverse prognostic factor for myeloma. Chim et al24 reported that LDH is an adverse prognostic factor independent of ISS in transplant-eligible myeloma patients receiving bortezomib-based induction regimens. Moreover, multivariate analysis including LDH, ISS stage, etc showed that ISS stage was no longer an independent prognostic factor.

Many studies show that combined treatments based on bortezomib do not seem to induce serious adverse reactions, and our results indicated this as well.3,12,13,16–20 PN is another common adverse effect of bortezomib; however, it has dose-limiting and reversible toxicity.25,26 In this study, the incidence of PN was higher in the PTD group compared to the PAD and PD groups, but whether bortezomib plus thalidomide increased the incidence of PN and its severity was not clear. Several clinical trials have evaluated the benefit of prolonging the administration interval of bortezomib as once-weekly IV injection and have shown that this strategy can significantly reduce the incidence rate of PN, without appearing to influence the efficacy.27,28 Similarly, the SC administration of bortezomib as twice-weekly injection was found to be noninferior in efficacy to standard twice-weekly IV administration, with an improved safety profile.29 Therefore, we began to give bortezomib by once-weekly SC injection to further reduce the incidence rate of PN. Our results showed that this strategy may reduce the incidence rate of PN without affecting efficacy. It was reported that the incidence rate of herpes zoster was 5%–13% in Europe and the US, but Asian patients had significantly higher incidence after treatments based on bortezomib.30,31 In our study, herpes zoster was observed in 28.8% of cases in the PTD group without preventive antiviral use, which was much higher than in other groups.

Conclusion

In conclusion, the combined treatment with the three drugs is proven to be superior to bortezomib plus dexamethasone, and the PAD regimen is noninferior in efficacy, with fewer adverse events. According to the occurrence rate and degree of PN, PAD is superior to PTD. SC injection of bortezomib decreases the incidence of PN requiring medical treatment in Chinese patients without sacrificing the efficacy of bortezomib. Therefore, SC injection of bortezomib should be considered in Chinese MM patients.