Christa Nederstigt1, Eleonora P M Corssmit2, Eelco J P de Koning3, Olaf M Dekkers4. 1. Department of Internal Medicine, Section Endocrinology, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands; Department of Clinical Epidemiology, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands; Medisch Centrum Haaglanden, Department of Internal Medicine, Lijnbaan 32, 2512 VA Den Haag, The Netherlands. Electronic address: c.nederstigt@lumc.nl. 2. Department of Internal Medicine, Section Endocrinology, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands. Electronic address: E.P.M.van_der_Kleij-Corssmit@lumc.nl. 3. Department of Internal Medicine, Section Endocrinology, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands. Electronic address: E.J.P.de_Koning@lumc.nl. 4. Department of Internal Medicine, Section Endocrinology, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands; Department of Clinical Epidemiology, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands; Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Allé 43-45, DK-8200 Aarhus, Denmark. Electronic address: O.M.dekkers@lumc.nl.
Abstract
AIMS: To estimate prevalence and incidence of auto-immune thyroid disease and thyroid auto-antibodies in an unselected cohort of patients with DM1, including stratification by age, gender and duration of diabetes. METHODS: Patients with T1D visiting our outpatient clinic between 1995 and 2011 were included. We calculated the prevalence of AITD at first screening and estimated prevalence and incidence rates during follow-up. RESULTS: A total of 1304 patients were included, 48.9% being female. Mean age of diabetes onset was 18.7 years. Of all patients without known thyroid disorder first screened for AITD, 10.3 % (n=104) was diagnosed with hypo- or hyperthyroidism. The average prevalence of AITD in our population was 112/1000 patients. We found 128 new cases of AITD, 101 cases of hypothyroidism and 27 of hyperthyroidism between 1995 and 2011 with accompanying incidences of 11.2/1000 person-years (95% CI 9.5-13.4), 8.9/1000 person-years (95% CI, 7.3-10.8) and 2.4/1000 person-years (95% CI, 1.6-3.5), respectively. Age-stratified incidence of AITD was comparable at all ages in both males and females, with an approximately two times higher incidence in females. CONCLUSIONS: The incidence of AITD among T1D patients is high, but stable among all ages and independent of diabetes duration.
AIMS: To estimate prevalence and incidence of auto-immune thyroid disease and thyroid auto-antibodies in an unselected cohort of patients with DM1, including stratification by age, gender and duration of diabetes. METHODS:Patients with T1D visiting our outpatient clinic between 1995 and 2011 were included. We calculated the prevalence of AITD at first screening and estimated prevalence and incidence rates during follow-up. RESULTS: A total of 1304 patients were included, 48.9% being female. Mean age of diabetes onset was 18.7 years. Of all patients without known thyroid disorder first screened for AITD, 10.3 % (n=104) was diagnosed with hypo- or hyperthyroidism. The average prevalence of AITD in our population was 112/1000 patients. We found 128 new cases of AITD, 101 cases of hypothyroidism and 27 of hyperthyroidism between 1995 and 2011 with accompanying incidences of 11.2/1000 person-years (95% CI 9.5-13.4), 8.9/1000 person-years (95% CI, 7.3-10.8) and 2.4/1000 person-years (95% CI, 1.6-3.5), respectively. Age-stratified incidence of AITD was comparable at all ages in both males and females, with an approximately two times higher incidence in females. CONCLUSIONS: The incidence of AITD among T1D patients is high, but stable among all ages and independent of diabetes duration.
Authors: Silvania da Silva Teixeira; Ana C Panveloski-Costa; Aline Carvalho; Fabiana P Monteiro Schiavon; Any de Castro Ruiz Marque; Raquel S Campello; Roberto B Bazotte; Maria T Nunes Journal: Physiol Rep Date: 2016-09