Literature DB >> 26867565

TAM receptor tyrosine kinase function and the immunopathology of liver disease.

S K Mukherjee1, A Wilhelm1, C G Antoniades2.   

Abstract

Tyro3, Axl, MERTK (TAM) receptor tyrosine kinases are implicated in the regulation of the innate immune response through clearance of apoptotic cellular debris and control of cytokine signaling cascades. As a result they are pivotal in regulating the inflammatory response to tissue injury. Within the liver, immune regulatory signaling is employed to prevent the overactivation of innate immunity in response to continual antigenic challenge from the gastrointestinal tract. In this review we appraise current understanding of the role of TAM receptor function in the regulation of both innate and adaptive immunity, with a focus on its impact upon hepatic inflammatory pathology.
Copyright © 2016 the American Physiological Society.

Entities:  

Keywords:  Axl; Mer; Tyro3, Axl, MERTK; antitumor immunity; immune regulation

Mesh：

Substances：

Year:  2016        PMID： 26867565      PMCID： PMC4935487          DOI： 10.1152/ajpgi.00382.2015

Source DB:  PubMed          Journal:  Am J Physiol Gastrointest Liver Physiol        ISSN： 0193-1857            Impact factor:   4.052


  79 in total

1.  Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family.

Authors:  Q Lu; G Lemke
Journal:  Science       Date:  2001-07-13       Impact factor: 47.728

2.  Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice.

Authors:  Ye-Ji Lee; Seung-Hae Lee; Young-So Youn; Ji-Yeon Choi; Keung-Sub Song; Min-Sun Cho; Jihee Lee Kang
Journal:  Toxicol Appl Pharmacol       Date:  2012-06-09       Impact factor: 4.219

3.  Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages.

Authors:  Alessandra A Filardy; Dayana R Pires; Marise P Nunes; Christina M Takiya; Celio G Freire-de-Lima; Flavia L Ribeiro-Gomes; George A DosReis
Journal:  J Immunol       Date:  2010-07-21       Impact factor: 5.422

Review 4.  Clearance of apoptotic cells in human SLE.

Authors:  U S Gaipl; A Kuhn; A Sheriff; L E Munoz; S Franz; R E Voll; J R Kalden; M Herrmann
Journal:  Curr Dir Autoimmun       Date:  2006

5.  Induction of immunological tolerance by porcine liver allografts.

Authors:  R Y Calne; R A Sells; J R Pena; D R Davis; P R Millard; B M Herbertson; R M Binns; D A Davies
Journal:  Nature       Date:  1969-08-02       Impact factor: 49.962

6.  Biological properties and gene expression associated with metastatic potential of human osteosarcoma.

Authors:  Tetsuhiro Nakano; Masachika Tani; Yasunori Ishibashi; Kenji Kimura; Yong-Bum Park; Natsuko Imaizumi; Hiroyuki Tsuda; Kazuhiko Aoyagi; Hiroki Sasaki; Susumu Ohwada; Jun Yokota
Journal:  Clin Exp Metastasis       Date:  2003       Impact factor: 5.150

7.  The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.

Authors:  G Manfioletti; C Brancolini; G Avanzi; C Schneider
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272

8.  Postmortem serum protein growth arrest-specific 6 levels in sepsis-related deaths.

Authors:  Cristian Palmiere; Marc Augsburger
Journal:  Int J Legal Med       Date:  2015-08-02       Impact factor: 2.686

Review 9.  Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.

Authors:  Robert D Schreiber; Lloyd J Old; Mark J Smyth
Journal:  Science       Date:  2011-03-25       Impact factor: 47.728

Review 10.  Axl as a mediator of cellular growth and survival.

Authors:  Haley Axelrod; Kenneth J Pienta
Journal:  Oncotarget       Date:  2014-10-15
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  13 in total

1.  Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer.

Authors:  Anna Zagórska; Paqui G Través; Lidia Jiménez-García; Jenna D Strickland; Joanne Oh; Francisco J Tapia; Rafael Mayoral; Patrick Burrola; Bryan L Copple; Greg Lemke
Journal:  Life Sci Alliance       Date:  2020-06-22

Review 2.  Gas6/TAM Axis in Sepsis: Time to Consider Its Potential Role as a Therapeutic Target.

Authors:  Livia Salmi; Francesco Gavelli; Filippo Patrucco; Marina Caputo; Gian Carlo Avanzi; Luigi Mario Castello
Journal:  Dis Markers       Date:  2019-08-14       Impact factor: 3.434

Review 3.  Gas6/TAM System: A Key Modulator of the Interplay between Inflammation and Fibrosis.

Authors:  Mattia Bellan; Micol Giulia Cittone; Stelvio Tonello; Cristina Rigamonti; Luigi Mario Castello; Francesco Gavelli; Mario Pirisi; Pier Paolo Sainaghi
Journal:  Int J Mol Sci       Date:  2019-10-12       Impact factor: 5.923

4.  A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target.

Authors:  Anna Tutusaus; Estefanía de Gregorio; Blanca Cucarull; Helena Cristóbal; Cristina Aresté; Isabel Graupera; Mar Coll; Anna Colell; Gro Gausdal; James B Lorens; Pablo García de Frutos; Albert Morales; Montserrat Marí
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2019-11-02

5.  Comparative Efficacy of Cabozantinib and Regorafenib for Advanced Hepatocellular Carcinoma.

Authors:  Robin K Kelley; Patrick Mollon; Jean-Frédéric Blanc; Bruno Daniele; Thomas Yau; Ann-Lii Cheng; Velichka Valcheva; Florence Marteau; Ines Guerra; Ghassan K Abou-Alfa
Journal:  Adv Ther       Date:  2020-05-18       Impact factor: 3.845

6.  Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2.

Authors:  Tatyana Novoyatleva; Nabham Rai; Baktybek Kojonazarov; Swathi Veeroju; Isabel Ben-Batalla; Paola Caruso; Mazen Shihan; Nadine Presser; Elsa Götz; Carina Lepper; Sebastian Herpel; Grégoire Manaud; Frédéric Perros; Henning Gall; Hossein Ardeschir Ghofrani; Norbert Weissmann; Friedrich Grimminger; John Wharton; Martin Wilkins; Paul D Upton; Sonja Loges; Nicholas W Morrell; Werner Seeger; Ralph T Schermuly
Journal:  Commun Biol       Date:  2021-08-24

Review 7.  GAS6/TAM Pathway Signaling in Hemostasis and Thrombosis.

Authors:  Luke A Law; Douglas K Graham; Jorge Di Paola; Brian R Branchford
Journal:  Front Med (Lausanne)       Date:  2018-05-09

Review 8.  High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway.

Authors:  Hyuk Moon; Kyungjoo Cho; Sunyeong Shin; Do Young Kim; Kwang-Hyub Han; Simon Weonsang Ro
Journal:  Int J Mol Sci       Date:  2019-01-29       Impact factor: 5.923

Review 9.  Gas6/TAM Signaling Components as Novel Biomarkers of Liver Fibrosis.

Authors:  Carlo Smirne; Cristina Rigamonti; Carla De Benedittis; Pier Paolo Sainaghi; Mattia Bellan; Michela Emma Burlone; Luigi Mario Castello; Gian Carlo Avanzi
Journal:  Dis Markers       Date:  2019-09-08       Impact factor: 3.434

10.  Growth Arrest-Specific Gene 6 Administration Ameliorates Sepsis-Induced Organ Damage in Mice and Reduces ROS Formation In Vitro.

Authors:  Livia Salmi; Francesco Gavelli; Filippo Patrucco; Mattia Bellan; Pier Paolo Sainaghi; Gian Carlo Avanzi; Luigi Mario Castello
Journal:  Cells       Date:  2021-03-09       Impact factor: 6.600
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