Literature DB >> 26866937

Protective Role of Adipose-Derived Stem Cells in Staphylococcus aureus-Induced Lung Injury is Mediated by RegIIIγ Secretion.

Jing Qian1, Yue Hu2,3, Lifang Zhao3, Jingyan Xia4, Changwei Li5, Liyun Shi6, Feng Xu3.   

Abstract

Effective and specific therapeutic approaches are still needed for treating acute lung injury caused by severe pneumonia. Adipose-derived stem cells (ADSCs) are well-characterized adult stem cells that have antibacterial and anti-inflammatory effects. In this study, we evaluated the therapeutic effect of ADSCs on Staphylococcus aureus-induced acute lung injury in mice. Our results showed that intratracheal injection of ADSCs could attenuate the severity of lung inflammation, and reduce the bacterial load as well as mortality among infected mice. Our experiments also revealed that the secretion of regenerating islet-derived IIIγ (RegIIIγ) is responsible for the protective effect of ADSCs. Moreover, the expression of RegIIIγ requires TLR2, MyD88, and JAK2/STAT3 activation. In conclusion, ADSCs exhibit a direct antimicrobial activity that is mediated primarily by the TLR2-MyD88-JAK2/STAT3-dependent secretion of RegIIIγ. Stem Cells 2016;34:1947-1956.
© 2016 The Authors STEM CELLS published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

Entities:  

Keywords:  Acute lung injury; Adipose-derived stem cells; Regenerating islet-derived IIIγ; Signaling pathways; Staphylococcus aureus

Mesh：

Substances：

Year:  2016        PMID： 26866937     DOI： 10.1002/stem.2337

Source DB:  PubMed          Journal:  Stem Cells        ISSN： 1066-5099            Impact factor:   6.277


  8 in total

1.  Adipose-derived stem cells decolonize skin Staphylococcus aureus by enhancing phagocytic activity of peripheral blood mononuclear cells in the atopic rats.

Authors:  Jaehee Lee; Leejin Park; Hyeyoung Kim; Bong-Il Rho; Rafael Taeho Han; Sewon Kim; Hee Jin Kim; Heung Sik Na; Seung Keun Back
Journal:  Korean J Physiol Pharmacol       Date:  2022-07-01       Impact factor: 1.718

2.  Current understanding of the therapeutic benefits of mesenchymal stem cells in acute respiratory distress syndrome.

Authors:  Miquéias Lopes-Pacheco; Chiara Robba; Patricia Rieken Macêdo Rocco; Paolo Pelosi
Journal:  Cell Biol Toxicol       Date:  2019-09-04       Impact factor: 6.691

3.  IL22 furthers malignant transformation of rat mesenchymal stem cells, possibly in association with IL22RA1/STAT3 signaling.

Authors:  Xiangrong Cui; Xuan Jing; Qin Yi; Zhongping Xiang; Jie Tian; Bin Tan; Jing Zhu
Journal:  Oncol Rep       Date:  2019-02-11       Impact factor: 3.906

4.  Mast cells participate in regulation of lung-gut axis during Staphylococcus aureus pneumonia.

Authors:  Chao Liu; Liping Yang; Yu Han; Wei Ouyang; Wei Yin; Feng Xu
Journal:  Cell Prolif       Date:  2019-02-07       Impact factor: 6.831

5.  Autophagy regulates the therapeutic potential of adipose-derived stem cells in LPS-induced pulmonary microvascular barrier damage.

Authors:  Chichi Li; Jingye Pan; Lechi Ye; Honglei Xu; Beibei Wang; Hanyan Xu; Lingna Xu; Tongtong Hou; Dan Zhang
Journal:  Cell Death Dis       Date:  2019-10-23       Impact factor: 8.469

6.  Single-Cell RNA Sequencing Reveals the Interaction of Injected ADSCs with Lung-Originated Cells in Mouse Pulmonary Fibrosis.

Authors:  Mamatali Rahman; Zhao-Yan Wang; Jun-Xiang Li; Hao-Wei Xu; Rui Wang; Qiong Wu
Journal:  Stem Cells Int       Date:  2022-04-11       Impact factor: 5.131

7.  The antibacterial effect of mesenchymThe antibacterial effect of mesenchymal stem cells on graft infections: An experimental studyal stem cells on graft infections: An experimental study.

Authors:  Mehmet Kabalcı; İbrahim Deniz Canbeyli; Erdinç Eroğlu
Journal:  Turk Gogus Kalp Damar Cerrahisi Derg       Date:  2018-09-16       Impact factor: 0.332

Review 8.  A preview of selected articles.

Authors:  Stuart P Atkinson
Journal:  Stem Cells Transl Med       Date:  2020-01-17       Impact factor: 6.940
  8 in total

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