PURPOSE: The aim of this study was to investigate the outcome in near vision and the best-corrected visual acuity in patients with wet, age-related macular degeneration treated with aflibercept in a fixed bimonthly regimen in an ordinary clinical setting. METHODS: The study was a retrospective, nonrandomized consecutive case series including 85 patients with wet, age-related macular degeneration followed for 18 months. During the first year all the patients received aflibercept injections in a fixed regimen at the following time points: Month 0, 1, 2, 4, 6, 8, 10, and 12. From Month 12 to Month 18, patients were treated with a treat and extend algorithm. RESULTS: The median near visual acuity improved from 12 points (95% confidence interval [CI] 10.5-13.4) at baseline to 5 points both at Month 12 (95% CI 3.8-6.2) and at Month 18 (95% CI 3.6-6.4) (P < 0.0001). At the 18-month visit, 58% (42/73) of the patients had a near visual acuity of at least 5 points compared with 7% (6/85) (P < 0.0001) at baseline. Best-corrected visual acuity improved from 60.9 letters (Snellen 20/63) (95% CI 58.4-63.4) at baseline to 68.1 letters (20/40) (95% CI 65.3-70.9) (P < 0.001) at Month 12 and 69.6 letters (20/40) (95% CI 66.7-72.5) (P < 0.001) at Month 18. CONCLUSION: Significant improvements were found in near vision and best-corrected visual acuity. The improvement in near vision was comparably greater than the change in best-corrected visual acuity. Monitoring near vision can contribute additional information when managing the patient with wet, age-related macular degeneration.
PURPOSE: The aim of this study was to investigate the outcome in near vision and the best-corrected visual acuity in patients with wet, age-related macular degeneration treated with aflibercept in a fixed bimonthly regimen in an ordinary clinical setting. METHODS: The study was a retrospective, nonrandomized consecutive case series including 85 patients with wet, age-related macular degeneration followed for 18 months. During the first year all the patients received aflibercept injections in a fixed regimen at the following time points: Month 0, 1, 2, 4, 6, 8, 10, and 12. From Month 12 to Month 18, patients were treated with a treat and extend algorithm. RESULTS: The median near visual acuity improved from 12 points (95% confidence interval [CI] 10.5-13.4) at baseline to 5 points both at Month 12 (95% CI 3.8-6.2) and at Month 18 (95% CI 3.6-6.4) (P < 0.0001). At the 18-month visit, 58% (42/73) of the patients had a near visual acuity of at least 5 points compared with 7% (6/85) (P < 0.0001) at baseline. Best-corrected visual acuity improved from 60.9 letters (Snellen 20/63) (95% CI 58.4-63.4) at baseline to 68.1 letters (20/40) (95% CI 65.3-70.9) (P < 0.001) at Month 12 and 69.6 letters (20/40) (95% CI 66.7-72.5) (P < 0.001) at Month 18. CONCLUSION: Significant improvements were found in near vision and best-corrected visual acuity. The improvement in near vision was comparably greater than the change in best-corrected visual acuity. Monitoring near vision can contribute additional information when managing the patient with wet, age-related macular degeneration.
Authors: Praveen J Patel; Helen Devonport; Sobha Sivaprasad; Adam H Ross; Gavin Walters; Richard P Gale; Andrew J Lotery; Sajjad Mahmood; James S Talks; Jackie Napier Journal: Clin Ophthalmol Date: 2017-11-06
Authors: Praveen J Patel; Hari Jayaram; Maria Eleftheriadou; Clara Vazquez-Alfageme; Niaz Islam; Gary S Rubin; Bishwanath Pal; Peter K Addison; Robin Hamilton; Simona Degli Esposti Journal: Ophthalmol Ther Date: 2020-06-18
Authors: Jan Nemcansky; Alexandr Stepanov; Michal Koubek; Miroslav Veith; Yun Min Klimesova; Jan Studnicka Journal: J Ophthalmol Date: 2019-06-10 Impact factor: 1.909
Authors: Peter J Kertes; Ivan J Galic; Mark Greve; Geoff Williams; Jason Baker; Marcel Lahaie; Tom Sheidow Journal: JAMA Ophthalmol Date: 2020-03-01 Impact factor: 7.389