| Literature DB >> 26866461 |
Sabrina Karwehl1,2, Rolf Jansen1,2, Volker Huch3, Marc Stadler1,2.
Abstract
Sorazolons A (1) to E2 (9) were isolated from Sorangium cellulosum strain Soce375. Their molecular structures were elucidated using extensive HRESIMS and NMR analysis. The absolute configuration of sorazolon A (1) was determined by comparison of the experimental CD spectrum with quantum chemical calculated spectra for both enantiomers. Sorazolons D2 (7), E (8), and E2 (9) exhibit a moderate cytotoxic activity against mouse fibroblast cell line L929 with IC50 values between 5.0 μM and 0.09 mM.Entities:
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Year: 2016 PMID： 26866461 DOI： 10.1021/acs.jnatprod.5b00997
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050