Literature DB >> 2686622

Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine.

L Pénicaud1, Y Hitier, P Ferré, J Girard.   

Abstract

The insulin-resistant obese fa/fa rat is a convenient model in which to study a potential effect of metformin, a biguanide used in the treatment of non-insulin-dependent diabetes, on insulin-mediated glucose utilization. Female fa/fa rats were given metformin orally for 8 days. Studies were performed on anaesthetized post-absorptive rats 5 h after the last dose of metformin. Glucose production and utilization were enhanced 1.5-fold in metformin-treated rats. The enhanced glucose production was almost entirely due to increased glucose recycling. The digestive tract was the only tissue responsible for the enhanced glucose utilization.

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Year:  1989        PMID： 2686622      PMCID： PMC1133356          DOI： 10.1042/bj2620881

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  35 in total

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Authors:  D H WILLIAMSON; J MELLANBY; H A KREBS
Journal:  Biochem J       Date:  1962-01       Impact factor: 3.857

2.  Tissue distribution of C14-labeled beta-phenethylbiguanide.

Authors:  A N WICK; C J STEWART; G S SERIF
Journal:  Diabetes       Date:  1960 May-Jun       Impact factor: 9.461

3.  Specific inhibition of gluconeogenesis by biguanides.

Authors:  F Meyer; M Ipaktchi; H Clauser
Journal:  Nature       Date:  1967-01-14       Impact factor: 49.962

4.  Mechanism of abnormal oral glucose tolerance of genetically obese fa/fa rats.

Authors:  F Rohner-Jeanrenaud; J Proietto; E Ionescu; B Jeanrenaud
Journal:  Diabetes       Date:  1986-12       Impact factor: 9.461

5.  Development of obesity in Zucker rats. Early insulin resistance in muscles but normal sensitivity in white adipose tissue.

Authors:  L Pénicaud; P Ferré; J Terretaz; M F Kinebanyan; A Leturque; E Doré; J Girard; B Jeanrenaud; L Picon
Journal:  Diabetes       Date:  1987-05       Impact factor: 9.461

6.  Mechanism of metformin action in non-insulin-dependent diabetes.

Authors:  R A Jackson; M I Hawa; J B Jaspan; B M Sim; L Disilvio; D Featherbe; A B Kurtz
Journal:  Diabetes       Date:  1987-05       Impact factor: 9.461

7.  Effect of metformin on insulin-stimulated glucose turnover and insulin binding to receptors in type II diabetes.

Authors:  R Nosadini; A Avogaro; R Trevisan; A Valerio; P Tessari; E Duner; A Tiengo; M Velussi; S Del Prato; S De Kreutzenberg
Journal:  Diabetes Care       Date:  1987 Jan-Feb       Impact factor: 19.112

8.  Effect of anesthesia on glucose production and utilization in rats.

Authors:  L Pénicaud; P Ferré; J Kande; A Leturque; T Issad; J Girard
Journal:  Am J Physiol       Date:  1987-03

9.  Effect of metformin on glucose metabolism in mouse soleus muscle.

Authors:  C J Bailey; J A Puah
Journal:  Diabete Metab       Date:  1986-08

10.  Studies on the site and mechanism of action of phenformin. II. Phenformin inhibition of glucose transport by rat intestine.

Authors:  F A Kruger; R A Altschuld; S L Hollobaugh; B Jewett
Journal:  Diabetes       Date:  1970-01       Impact factor: 9.461
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  29 in total

1.  Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.

Authors:  M R Owen; E Doran; A P Halestrap
Journal:  Biochem J       Date:  2000-06-15       Impact factor: 3.857

2.  Metformin and the intestine.

Authors:  C J Bailey; C Wilcock; J H B Scarpello
Journal:  Diabetologia       Date:  2008-06-05       Impact factor: 10.122

Review 3.  The antihyperglycaemic effect of metformin: therapeutic and cellular mechanisms.

Authors:  N F Wiernsperger; C J Bailey
Journal:  Drugs       Date:  1999       Impact factor: 9.546

Review 4.  Glucose transporters in the small intestine in health and disease.

Authors:  Hermann Koepsell
Journal:  Pflugers Arch       Date:  2020-08-23       Impact factor: 3.657

5.  Oral vanadate decreases muscle insulin resistance in obese fa/fa rats.

Authors:  S M Brichard; L N Ongemba; J C Henquin
Journal:  Diabetologia       Date:  1992-06       Impact factor: 10.122

6.  Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.

Authors:  Patricia W Seo-Mayer; Gunilla Thulin; Li Zhang; Daiane S Alves; Thomas Ardito; Michael Kashgarian; Michael J Caplan
Journal:  Am J Physiol Renal Physiol       Date:  2011-08-17

Review 7.  Prevention of complications in non-insulin-dependent diabetes mellitus (NIDDM).

Authors:  B H Wolffenbuttel; T W van Haeften
Journal:  Drugs       Date:  1995-08       Impact factor: 9.546

8.  High and typical 18F-FDG bowel uptake in patients treated with metformin.

Authors:  Eric Gontier; Emmanuelle Fourme; Myriam Wartski; Cyrille Blondet; Gerald Bonardel; Elise Le Stanc; Marina Mantzarides; Herve Foehrenbach; Alain-Paul Pecking; Jean-Louis Alberini
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-09-05       Impact factor: 9.236

9.  Insulin requirement for the antihyperglycaemic effect of metformin.

Authors:  C J Bailey; K J Mynett
Journal:  Br J Pharmacol       Date:  1994-03       Impact factor: 8.739

10.  Effect of metformin on glucose metabolism in the splanchnic bed.

Authors:  C J Bailey; C Wilcock; C Day
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739
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