Literature DB >> 26865711

Hepatitis B Virus Infection of a Mouse Hepatic Cell Line Reconstituted with Human Sodium Taurocholate Cotransporting Polypeptide.

Florian A Lempp1, Bingqian Qu1, Yong-Xiang Wang2, Stephan Urban3,4.   

Abstract

Hepatitis B virus (HBV) enters hepatocytes via its receptor, human sodium taurocholate cotransporting polypeptide (hNTCP). So far, HBV infection has been achieved only in human hepatic cells reconstituted with hNTCP and not in cells of mouse origin. Here, the first mouse liver cell line (AML12) which gains susceptibility to HBV upon hNTCP expression is described. Thus, HBV infection of receptor-expressing mouse hepatocytes does not principally require a human cofactor but can be triggered by endogenous murine determinants.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID: 26865711      PMCID: PMC4836309          DOI: 10.1128/JVI.02832-15

Source DB:  PubMed          Journal:  J Virol        ISSN: 0022-538X            Impact factor:   5.103


  18 in total

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Review 10.  Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection.

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