| Literature DB >> 26865711 |
Florian A Lempp1, Bingqian Qu1, Yong-Xiang Wang2, Stephan Urban3,4.
Abstract
Hepatitis B virus (HBV) enters hepatocytes via its receptor, human sodium taurocholate cotransporting polypeptide (hNTCP). So far, HBV infection has been achieved only in human hepatic cells reconstituted with hNTCP and not in cells of mouse origin. Here, the first mouse liver cell line (AML12) which gains susceptibility to HBV upon hNTCP expression is described. Thus, HBV infection of receptor-expressing mouse hepatocytes does not principally require a human cofactor but can be triggered by endogenous murine determinants.Entities:
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Year: 2016 PMID: 26865711 PMCID: PMC4836309 DOI: 10.1128/JVI.02832-15
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103