| Literature DB >> 26865105 |
Benjamin W Lee1,2, Bohao Liu1,2, Adam Pluchinsky1, Nathan Kim1, George Eng1,2, Gordana Vunjak-Novakovic1,3.
Abstract
This modular assembly approach to microfabricate functional cardiovascular tissue composites enables quantitative assessment of the effects of microarchitecture on cellular function. Cardiac and endothelial modules are micromolded separately, designed to direct cardiomyocyte alignment and anisotropic contraction or vascular network formation. Assembled cardiovascular tissue composites contract synchronously, facilitating the use of this tissue-engineering platform to study structure-function relationships in the heart.Entities:
Keywords: anisotropy; cardiac tissue engineering; hydrogels; micropatterning; modular assembly
Mesh:
Year: 2016 PMID: 26865105 PMCID: PMC4836958 DOI: 10.1002/adhm.201500956
Source DB: PubMed Journal: Adv Healthc Mater ISSN: 2192-2640 Impact factor: 9.933