Literature DB >> 2686438

The central role of obesity (hyperinsulinemia) in the pathogenesis of the polycystic ovary syndrome.

J E Nestler1, J N Clore, W G Blackard.   

Abstract

Insulin resistance and hyperinsulinemia appear to be almost universal features of the polycystic ovary syndrome. We propose that obesity permits full phenotypic expression of the polycystic ovary syndrome in women predisposed to develop this condition by generating an insulin-resistant, and consequently hyperinsulinemic, state. The resultant hyperinsulinemia may produce hyperandrogenism by affecting multiple facets of androgen metabolism.

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Year:  1989        PMID： 2686438     DOI： 10.1016/0002-9378(89)90640-6

Source DB:  PubMed          Journal:  Am J Obstet Gynecol        ISSN： 0002-9378            Impact factor:   8.661


  11 in total

Review 1.  Premature adrenarche.

Authors:  P Saenger; J Dimartino-Nardi
Journal:  J Endocrinol Invest       Date:  2001-10       Impact factor: 4.256

2.  Gonadotropin levels in women with polycystic ovary syndrome: their relationship to body weight and insulin levels.

Authors:  G Tropeano; I P Vuolo; A Lucisano; L Liberale; A Barini; P Carfagna; G Caroli; E Menini; S dell'Acqua
Journal:  J Endocrinol Invest       Date:  1996-03       Impact factor: 4.256

3.  Diet-induced obesity exacerbates metabolic and behavioral effects of polycystic ovary syndrome in a rodent model.

Authors:  Ilana B Ressler; Bernadette E Grayson; Yvonne M Ulrich-Lai; Randy J Seeley
Journal:  Am J Physiol Endocrinol Metab       Date:  2015-04-14       Impact factor: 4.310

4.  Association of polymorphisms of interleukin-18 gene promoter region with polycystic ovary syndrome in chinese population.

Authors:  Yan Yang; Jie Qiao; Mei-Zhi Li
Journal:  Reprod Biol Endocrinol       Date:  2010-10-22       Impact factor: 5.211

5.  Hyperinsulinemia in polycystic ovary syndrome: relationship to clinical and hormonal factors.

Authors:  A Vidal-Puig; M Muñoz-Torres; E Jodar-Gimeno; C García-Calvente; P Lardelli; M E Ruiz-Requena; F Escobar-Jiménez
Journal:  Clin Investig       Date:  1994-11

Review 6.  Premature pubarche, ovarian hyperandrogenism, hyperinsulinism and the polycystic ovary syndrome: from a complex constellation to a simple sequence of prenatal onset.

Authors:  L Ibáñez; F de Zegher; N Potau
Journal:  J Endocrinol Invest       Date:  1998-10       Impact factor: 4.256

7.  The role of hyperinsulinemia in the development of lipid disturbances in nonobese and obese women with the polycystic ovary syndrome.

Authors:  J Slowińska-Srzednicka; S Zgliczyński; M Wierzbicki; M Srzednicki; U Stopińska-Gluszak; W Zgliczyński; P Soszyński; E Chotkowska; M Bednarska; Z Sadowski
Journal:  J Endocrinol Invest       Date:  1991 Jul-Aug       Impact factor: 4.256

8.  Body shape and size and insulin resistance as early clinical predictors of hyperandrogenic anovulation in ethnic minority adolescent girls.

Authors:  Jessica Rieder; Nanette Santoro; Hillel W Cohen; Paul Marantz; Susan M Coupey
Journal:  J Adolesc Health       Date:  2008-05-19       Impact factor: 5.012

9.  An Evaluation of Infertility Among Women in the Republic of Palau, 2016.

Authors:  Kristen M Kreisel; Edolem Ikerdeu; Haley L Cash; Stacy L De Jesus; Mary L Kamb; Tranita Anderson; Roxanne Y Barrow; Mindy S Sugiyama; Kliu Basilius; Sherilynn Madraisau
Journal:  Hawaii J Health Soc Welf       Date:  2020-01

10.  Is interleukin-18 associated with polycystic ovary syndrome?

Authors:  Yan Yang; Jie Qiao; Rong Li; Mei-Zhi Li
Journal:  Reprod Biol Endocrinol       Date:  2011-01-18       Impact factor: 5.211
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