Giannis Arnaoutis1, Stavros A Kavouras2, Nikolaos Stratakis1, Marita Likka3, Asimina Mitrakou3, Christos Papamichael3, Labros S Sidossis1,4, Kimon Stamatelopoulos3. 1. Department of Nutrition and Dietetics, Harokopio University, Athens, Greece. 2. Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, 72701, USA. kavouras@uark.edu. 3. Vascular Laboratory, Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece. 4. Department of Exercise Science and Sports Studies, Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Jersey, USA.
Abstract
PURPOSE:Hypohydration has been suggested as a predisposing factor for several pathologies including cardiovascular diseases (CVD). While CVD are the leading cause of death worldwide, no study has investigated whether acute hypohydration affects endothelial function and cardiovascular function. METHODS:Ten young, healthy males participated in this crossover study (age: 24.3 ± 2.3 year; weight: 80.8 ± 5.3 kg; BMI: 24.3 ± 0.4 kg m-2). Each subject completed two measurements of endothelial function by flow-mediated dilation (FMD) in euhydrated and hypohydrated state separated by 24 h. Following baseline assessment of hydration status and FMD, the subjects completed 100 min of low-intensity intermittent walking exercise to achieve hypohydration of -2 % of individual body mass. For the rest of the day, a standardized, low water content diet was provided. The following morning, hydration markers and endothelial function were recorded. RESULTS:Hypohydration by -1.9 ± 0.1 % of body mass resulted in decreased plasma volume by -3.5 ± 1.8 % and increased plasma osmolality by 9 ± 2 mmol kg-1 (P < 0.001). FMD as a response to hypohydration decreased by -26.8 ± 3.9 % (P < 0.05). CONCLUSION: The data suggested that a small degree of hypohydration induced by moderate exercise and fluid restriction significantly impaired endothelial function.
RCT Entities:
PURPOSE: Hypohydration has been suggested as a predisposing factor for several pathologies including cardiovascular diseases (CVD). While CVD are the leading cause of death worldwide, no study has investigated whether acute hypohydration affects endothelial function and cardiovascular function. METHODS: Ten young, healthy males participated in this crossover study (age: 24.3 ± 2.3 year; weight: 80.8 ± 5.3 kg; BMI: 24.3 ± 0.4 kg m-2). Each subject completed two measurements of endothelial function by flow-mediated dilation (FMD) in euhydrated and hypohydrated state separated by 24 h. Following baseline assessment of hydration status and FMD, the subjects completed 100 min of low-intensity intermittent walking exercise to achieve hypohydration of -2 % of individual body mass. For the rest of the day, a standardized, low water content diet was provided. The following morning, hydration markers and endothelial function were recorded. RESULTS: Hypohydration by -1.9 ± 0.1 % of body mass resulted in decreased plasma volume by -3.5 ± 1.8 % and increased plasma osmolality by 9 ± 2 mmol kg-1 (P < 0.001). FMD as a response to hypohydration decreased by -26.8 ± 3.9 % (P < 0.05). CONCLUSION: The data suggested that a small degree of hypohydration induced by moderate exercise and fluid restriction significantly impaired endothelial function.
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